DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and KMT2C

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_005250082.1	Gene:	KMT2C / 58508	HGNCID:	13726	Length:	4983	Species:	Homo sapiens

Alignment Length:	1712	Identity:	297/1712 - (17%)
Similarity:	490/1712 - (28%)	Gaps:	744/1712 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PASREKSYGLP----VRKGENSLE-------------SPAEQAAKDV--------EIEELTHSEA 64
            |.|.....|.|    |::|..:|.             :||..||..|        :...:||..:
Human  3534 PDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHS 3598

  Fly    65 IAATGSTRKQCP-YGGKAPDEPGK---LADESEDRKGENTKAIA------SSPVLVAVDSDSSVE 119
            .  .|||:.... |....|:|.||   ...:..|...|:|||.:      ::|....:...:|..
Human  3599 Y--PGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTP 3661

  Fly   120 LIESPVKF-SSANESEKDPPKPDAVNEAAAKEAEEM------TDSSISSPTSESF---------- 167
            .:.:|.:. ..|::...:|..|...|.||.:...|:      :|.|.::|..:::
Human  3662 AVSTPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSM 3726

  Fly   168 --PEKDE--KTNKENEQEPPGMEVDQDVEE-----------------------SISRPAEE---- 201
              |.|.|  |..|...:..||.| :..:||                       |...||.:
Human  3727 ETPAKTEEIKLEKAETESCPGQE-EPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSG 3790

  Fly   202 -YKIENTLKGHKRISLTE-------------IEEHKIVDKKD-----DVLEVELEKG-------- 239
             ..:::.||..|..||..             .:::|:|:|::     ..|..:::.|
Human  3791 NELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLP 3855

  Fly   240 ------------------TAPKAA--------EDEKLNALLSDGDVFYDKECVNCNCTKLHKQYV 278
                              |..|||        ::|:..|:.|..|.|          |.|.:|..
Human  3856 KTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTF----------THLKQQLS 3910

  Fly   279 LANMAT----LNFYQVLRKSS------------------------------KQQFLC-------- 301
            |..:..    :||...|...|                              ||..|.
Human  3911 LLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYKQNNLSNPPTPPAS 3975

  Fly   302 -------MGCHDTA--MDLYEEYAGQ---------------------------LMAK-------- 322
                   |.|...|  ....||.||:                           |:|:
Human  3976 LPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKT 4040

  Fly   323 ---------------QPLLLKDF--HQDHADFVALDSSDEE----EEEKQPEKSDFSKNKLQLIE 366
                           :.|.::|.  .:|..|.....||.|.    |..:.|:        |.|::
Human  4041 VDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPD--------LSLVK 4097

  Fly   367 DELDDAIKN-VLNKVDFTAQLSWSKTILQAKADHLERQFA-------------LADVELEKVQTT 417
            :|..:.:.: ::..:..||..|........|.:.....||             |..|.:....|.
Human  4098 EEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTA 4162

  Fly   418 A-----------DKMHCALYNSCPVAH-KHLPTLDIEPSDYVHEV--------------PPPG-- 454
            |           |.:|..:.||..|:. ..:|::.:..|   |.:              ||||
Human  4163 AENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSS---HRINPGLEYRQHLLLRGPPPGSA 4224

  Fly   455 --------------EIVRPPIQLGETYYAVKNKAIASWVSI--------KVI--------EFTES 489
                          .:..||...|.:.|...:..||...::        ||:        .|.:.
Human  4225 NPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDL 4289

  Fly   490 TAINGNTMKSYK--------------IRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIG------T 534
            |.:|.::.:|.|              |.|.:|. |...:...:.|......|:|.|..      :
Human  4290 TLLNKDSRESTKRVEKDIVFCSNNCFILYSSTA-QAKNSENKESIPSLPQSPMRETPSKAFHQYS 4353

  Fly   535 RVIAYFDGTTLSRGKDKGVVQS----AFYPG-----IIAEP--------LKQANRYRYLIFYDDG 582
            ..|:..|...|.:..:|....:    ||.|.     :.|:|        ||...|..:..|.|
Human  4354 NNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFED-- 4416

  Fly   583 YTQYVPHRDVRLVCQASEKVWE-------DVHAA---------SRDFIQKYVEKYS-------VD 624
                         |:...|.|.       .:|..         ..|.|.::::|..       |.
Human  4417 -------------CRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVP 4468

  Fly   625 RPMVQC----TRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRET 685
            :...:|    ..|..:|   :|.   ||::::|..|             |::...........||
Human  4469 KDYRKCCFCHEEGDGLT---DGP---ARLLNLDLDL-------------WVHLNCALWSTEVYET 4514

  Fly   686 QNN--MNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMR-AFARKSSASAQNNALAAASSAAT 747
            |..  :|                      :|.:.:...||: .|..|:.|::..:....
Human  4515 QAGALIN----------------------VELALRRGLQMKCVFCHKTGATSGCHRFRC------ 4551

  Fly   748 PAGGRTNAGGVSTSNSASAVRHLNNS-----------------------TIYVD-DENRP----- 783
                 ||....:.:..|..:...:.:                       .:||. ||.|.
Human  4552 -----TNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIV 4611

  Fly   784 ----------KGHVVYFTAKRNLPPKMYKCHECSPNCLF-------------------------- 812
                      .|.:::.|..:.||.:|...|  ||..||
Human  4612 QRGERDHTFRVGSLIFHTIGQLLPQQMQAFH--SPKALFPVGYEASRLYWSTRYANRRCRYLCSI 4674

  Fly   813 -----------KIVHR------LDSYSPLAKPLLSGWERLV-----MRQKTKKSVVYKGPC---G 852
                       :||.:      |...||...     |::::     :|:|::...::  |.   |
Human  4675 EEKDGRPVFVIRIVEQGHEDLVLSDISPKGV-----WDKILEPVACVRKKSEMLQLF--PAYLKG 4732

  Fly   853 KSLRSL--AEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPL-VN 914
            :.|..|  :.|.|...:...|...:|:.|        .|..:|             .|.:|| ||
Human  4733 EDLFGLTVSAVARIAESLPGVEACENYTF--------RYGRNP-------------LMELPLAVN 4776

  Fly   915 YYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPI 979
                  |..|..::   |....|:   :.|:|   .....:..|....:|.||.|
Human  4777 ------PTGCARSE---PKMSAHV---KRFVL---RPHTLNSTSTSKSFQSTVTG---------- 4816

  Fly   980 EEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNR--GWGLRCVNDIP 1042
             |:...|.:...|..:..|.                :...|.|..|:...:|  |.||....||.
Human  4817 -ELNAPYSKQFVHSKSSQYR----------------KMKTEWKSNVYLARSRIQGLGLYAARDIE 4864

  Fly  1043 KGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPD 1107
            |...:..|.|.::..                     |||.:.::.||
Human  4865 KHTMVIEYIGTIIRN---------------------EVANRKEKLYE------------------ 4890

  Fly  1108 AEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLF 1172
                                                 ||.|.|..|..:.|
Human  4891 -------------------------------------SQNRGVYMFRMDND-------------- 4904

  Fly  1173 GKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNV-FVDTHDLRFPWVAFFSAAHIRSGTELTWNY 1236
                  :::||..||...||.||||:||...:.| |...|.     :...|:..|:.|.||.::|
Human  4905 ------HVIDATLTGGPARYINHSCAPNCVAEVVTFERGHK-----IIISSSRRIQKGEELCYDY 4958

  Fly  1237 NYEVGVVPGKVLYCQCGAPNCR 1258
            .::......|: .|.|||.|||
Human  4959 KFDFEDDQHKI-PCHCGAVNCR 4979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	12/65 (18%)
		Pre-SET	901..1013	CDD:282838	20/112 (18%)
		SET	1022..1239	CDD:214614	43/219 (20%)
KMT2C	XP_005250082.1	ePHD1_KMT2C	248..331	CDD:277166
		PHD1_KMT2C_like	344..389	CDD:276984
		PHD2_KMT2C	391..436	CDD:277069
		PHD3_KMT2C	467..518	CDD:276986
		PHD4_KMT2C	953..1009	CDD:277071
		PHD5_KMT2C_like	1010..1056	CDD:276988
		RanBP2-type Zn finger	1085..1107	CDD:275375
		PHD6_KMT2C	1087..1137	CDD:277073
		HMG-box	1671..1722	CDD:294061
		DUF2962	1709..>1792	CDD:288077
		SYCE1	<3198..3287	CDD:291886
		ePHD2_KMT2C	4474..4578	CDD:277167	22/155 (14%)
		FYRN	4624..4674	CDD:283589	9/51 (18%)
		FYRC	4680..4761	CDD:283590	16/87 (18%)
		SET	<4797..4983	CDD:225491	61/312 (20%)
		SET	4844..4965	CDD:214614	42/221 (19%)
		PostSET	4967..4983	CDD:214703	8/14 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930