DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and kmt2cb

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_009296384.1	Gene:	kmt2cb / 568162	ZFINID:	ZDB-GENE-070705-340	Length:	4892	Species:	Danio rerio

Alignment Length:	1580	Identity:	288/1580 - (18%)
Similarity:	463/1580 - (29%)	Gaps:	638/1580 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 YGGKAPDEPGKLADESEDRKGENTKAI------------ASSPVLVAVDSDSSVELIESPVKFSS 129
            |....|:|.||.....:.:|.|:.:::            .::|:...| ||:|.....:|:.|..
Zfish  3549 YSNIIPEEKGKKKRNQKKKKDEDCESLRAPSTPHTPHSDMTAPLTPCV-SDTSSTPTRNPMVFGD 3612

  Fly   130 ANESEKDPPKPDAVNEAAAKEAEEMTDSSISS-PTSESFPEKDEKTNKENEQEPPGMEVDQDVEE 193
            ....|...|             ...|..|:|| |.||...:..|.:.....:...|.|   ::.:
Zfish  3613 HEFCETSQP-------------GSSTPGSMSSQPHSELERQLSEGSCGGGPESAMGHE---EMHD 3661

  Fly   194 SISRPAEEYKIE-NTLKGHK------RISLTEIEEHKIVDKKDDVLEVELEKGTAPKAA---EDE 248
            .|....:..|:| |...|||      ||.:.::|.           |:.|...::...|   ::|
Zfish  3662 RILSNIKLEKVEANDCHGHKPIDMEIRIGMVKVER-----------EIMLHHPSSQSPANSSKEE 3715

  Fly   249 KLNALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYE 313
            ..|.||                     :::|.|..|
Zfish  3716 GGNELL---------------------KHLLKNKRT----------------------------- 3730

  Fly   314 EYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLN 378
                     .|..|.  ||.     :.||...|||.....|:.|.:|.:.......|.      |
Zfish  3731 ---------PPHALP--HQR-----SEDSLRSEEEGSTESKAFFRQNSMDSTGTFSDS------N 3773

  Fly   379 KVDFTAQLSWSKTILQAKADHLERQFALA--------------DVELEKVQTTADKMHCALYNSC 429
            ..||...|     ||:.|.....::...:              :.|.:.|.::.|.|      ..
Zfish  3774 HQDFPGPL-----ILEDKKKQRNKRTPKSGDRPAPRCKKRKKEEDESQAVYSSTDPM------IT 3827

  Fly   430 PVAHKHLPTLDI-EP---SDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTEST 490
            |:..:||..|.: ||   .::.|.:|..|..:....:|..|:.:.....::.:.|..:
Zfish  3828 PLKQQHLSLLPLMEPLVGVNFAHLMPYGGGQLDGENRLSGTFGSASLDGVSDYYSQLI------- 3885

  Fly   491 AINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPV---RLTIG---TRVIAYFDGTTLSRGK 549
                     ||...|:.|.....::..      .||||   :|..|   |..:|...|.......
Zfish  3886 ---------YKQNNLSNPPTPPASLPP------TPPPVARQKLLNGFATTEELARKGGLIAGHDV 3935

  Fly   550 DKGV----VQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYV-------PHRDVRLVCQASEKVW 603
            .||:    ::......::|:.|.|..:           |..|       ||.:       .|::.
Zfish  3936 TKGLLARPLEFKAEEELLAQALAQGPK-----------TVNVPASLPTPPHNN-------QEELR 3982

  Fly   604 EDVHAASRDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCS----LVLMQFEGD 664
            ...|...|:....:|               .|.:.||        |:.::.|    |.|::.|..
Zfish  3983 GQEHCEDRNTPDSFV---------------PSSSPES--------VVGMEISRYPDLSLVKEEPP 4024

  Fly   665 KNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEP----FIRYTKEMESSSKVNQQMRA 725
            ......:    :.:.||||:....:     |::    :|||    |....:.:::.|.......|
Zfish  4025 SPAMSPV----IPMFPVFRDKDVKL-----QEV----KTEPSSVFFDSSFRSVQNGSNTGLVSIA 4076

  Fly   726 FARKSSASAQNNALAAA----------SSAATPAGGRTNAGGVSTS-----------NSASAVR- 768
            ...|.:|:.....:.||          ||....:|...:.|.:.||           |...|:|
Zfish  4077 IMLKPAAAENITDVVAAIADLIRVKIPSSYEVSSGPGGSFGAIKTSVDPQCLASALPNGPRALRQ 4141

  Fly   769 --------HLNNSTI----YVDDENRP----------------KGHVVYFTAKRNLPPKMYK-CH 804
                    |.:|..|    |.|.:.||                || |...|....:.|:..: |.
Zfish  4142 APQHLLLQHNHNKNIGGEQYRDGQVRPGSKQQWCQHCKVVVLGKG-VRKITKDEEVKPQESRLCS 4205

  Fly   805 E-----CSPNCLFKIVHRLDSYS------PLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSL 858
            :     ||.:||  |:|...|.|      ..:.||||   ...::|                 |.
Zfish  4206 DGGLVFCSHSCL--ILHSSSSQSNGNADNKASVPLLS---ESALKQ-----------------SF 4248

  Fly   859 AEV-HRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSI------------------VKDTDISKG 904
            ::| |:|   :.|:.::       |:.|||:....||.                  .|...||:|
Zfish  4249 SKVQHQY---SNNMSSL-------DVHCLAQLQPKPSSPAPYLHMAFAPAKAIKTESKPRSISEG 4303

  Fly   905 QEKMAIPLVNYYDNTLPP-----------------PCTYAKQRIPTEGVHLNLDEEF-------- 944
            ..|:.:.|.....:.|..                 ....|..::..:.....|:|..
Zfish  4304 HLKVTVKLKPRLHSHLEDKQWHHGKRWKGLRWRKWTIDIAMPKVAPQSSESELEERLKQLTTSLR 4368

  Fly   945 --------LLCCDCE---DDCSD--------------KSKCACWQLTVAGVRYCNPKKPIEEIGY 984
                    ..||.|:   |..:|              ...||.|...|    |......:..:|.
Zfish  4369 PCLTIRDQRRCCFCQQIGDGMTDGPARLLNLDLDTWVHLNCALWSSEV----YETQAGALINVGL 4429

  Fly   985 QYKRLHEHVPTGIYECNSRCKCKK-NCLNRVVQF--SLEMKLQVFKTSN--------RGWG---- 1034
            ..:|....|........:...|.: .||| :..|  :|:.....||...        ||.|
Zfish  4430 ARQRGQTVVCAFCQRLGATSGCHRLRCLN-IYHFTCALQAGCTFFKDKTMLCHQHRPRGAGAAAG 4493

  Fly  1035 ------LRCVNDIPKGAFICIY-----------------------AGHLLTETMAN--------- 1061
                  |||.:     .|..:|                       .|.||...|..
Zfish  4494 LHVEHQLRCFS-----VFRRVYVQRDELRQLAAAVQQPERGHTFRVGSLLFHAMGQLPPALMPTF 4553

  Fly  1062 -------EGGQDAGDEYFA------DLDYIEVAEQ-----------LKEGYESEV--DHSDPDAE 1100
                   ..|.:|...|::      ...|:...|:           :::|||..|  |.|.....
Zfish  4554 HSSTAIFPPGYEATRLYWSMRHGQKRCRYVCSVEEHEGRAEFSIRVIEQGYEDLVLTDTSAKGVW 4618

  Fly  1101 EDNGGPDAE----------------DDDDF---------------------RPNYHYQRK----- 1123
            |...||.||                .:|.|                     |..:.|.|.
Zfish  4619 EKVLGPVAERRAETGMLRLFPIYLKGEDLFGLTISAVTRIAESLPGVEACSRYRFRYGRNPLLVL 4683

  Fly  1124 -IKRSSRSGST--------------------------QNSSTQSS----------ELDSQERAVI 1151
             :..:| |||.                          |||:..:|          ...||.|.:.
Zfish  4684 PLSMNS-SGSARSELQTYPQHERVKILSSWPRISRCIQNSTVAASASSHSKHFVHSKSSQYRRLA 4747

  Fly  1152 N------------------FNPNADLDETV----------RENSVRR--LF-GKDEAPY------ 1179
            :                  |...|...:|:          .|.::||  |: .|:...|
Zfish  4748 SDWKSNVYLAHSRIQGLGLFAARAIEKQTMVIEYMGDILRTEVAMRRELLYKAKNRPAYMFCIDS 4812

  Fly  1180 --IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNY---- 1238
              ::||..:|:..||.|||||||...:.|..:    |...:...:|..|..|.||.::|..
Zfish  4813 ERVIDATNSGSPARYINHSCSPNCVAEVVTFE----RGYKIIISAACRIERGEELCYDYKLTPVN 4873

  Fly  1239 EVGVVPGKVLYCQCGAPNCR 1258
            :...:|     |.|||..||
Zfish  4874 DQSKIP-----CHCGAAKCR 4888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	10/56 (18%)
		Pre-SET	901..1013	CDD:282838	25/162 (15%)
		SET	1022..1239	CDD:214614	75/414 (18%)
kmt2cb	XP_009296384.1	PHD_SF	232..319	CDD:304600
		PHD1_KMT2C_like	332..377	CDD:276984
		PHD2_KMT2C	379..424	CDD:277069
		PHD3_KMT2C	459..507	CDD:276986
		PHD_SF	947..1003	CDD:304600
		PHD5_KMT2C_like	1004..1050	CDD:276988
		PHD_SF	1081..1131	CDD:304600
		HMG	1691..1744	CDD:197700
		DUF4200	3168..3262	CDD:290574
		Med15	3255..>3659	CDD:255446	26/126 (21%)
		PHD_SF	4379..4483	CDD:304600	21/108 (19%)
		FYRN	4536..4586	CDD:283589	7/49 (14%)
		FYRC	4594..4673	CDD:283590	14/78 (18%)
		SET	4753..4868	CDD:214614	28/118 (24%)
		PostSET	4877..4892	CDD:214703	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930