DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and kmt2ca

DIOPT Version :9

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:XP_005162602.1 Gene:kmt2ca / 560793 ZFINID:ZDB-GENE-080520-3 Length:4958 Species:Danio rerio


Alignment Length:1551 Identity:276/1551 - (17%)
Similarity:470/1551 - (30%) Gaps:574/1551 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGQPTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQA-AKDVEIEELTHSEA 64
            |:|.|::...:..||||                 |:|: :.|:.|.||.. ..|:::|:|..|..
Zfish  3685 MTGLPSSELEISLSGST-----------------PLRR-QTSVSSEAEHGLLHDIKLEKLESSVC 3731

  Fly    65 IAATGSTRKQCPYGGKAPDEPGKLADESEDRKGENTKAIASSPVLVAVDSDSSVELIESPVKFSS 129
            ..|.|    :.|.|..| :|.|.:..|..:....:.:. :.||. .:...:...||::..:|   
Zfish  3732 QKAEG----EAPVGHSA-EETGIIKTEEVNEIISHNRT-SQSPA-QSTKGEPGNELLKHLLK--- 3786

  Fly   130 ANESEKDPPKPDA------VNEAAAKEAEEMTDS----------SISSPTSE------SFPEKDE 172
               ::..||.|.|      .||:...|.|.:.||          |:|...|.      |.||:.:
Zfish  3787 ---NKNTPPPPSAPLMHQMSNESLRSEDEGLNDSKGYLRQDSTDSMSGINSRLTDLEPSLPEQCK 3848

  Fly   173 KTNKENEQEPPGMEVDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKDDVLEVELE 237
            | .:.|::.|         :..:.:|...:|        ||             |||        
Zfish  3849 K-KQRNKRTP---------KNGVDKPPSRWK--------KR-------------KKD-------- 3874

  Fly   238 KGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQY----VLANMATLNFYQVLRKSSKQ- 297
                    |||: .|:.::.|..         .|:|.:|.    ::..:..:||.......|.| 
Zfish  3875 --------EDER-QAIYTNTDTL---------MTQLKQQLSMLPLMEPLIGVNFAHFPPYGSGQL 3921

  Fly   298 ---QFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSK 359
               ..|.......::|...:|..||:.||.              .|.:.........|.....::
Zfish  3922 NGENRLSGSFGSASLDGVSDYYSQLIYKQN--------------NLSNPPTPPASLPPTPPPVAR 3972

  Fly   360 NKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKA---DHLERQFALADVELEKVQTTADKM 421
            .||              ||......:|:....::.:|:   ..|...|...|..|....|...| 
Zfish  3973 QKL--------------LNGFATAEELARKAEVMVSKSLGQKQLTASFKAEDDLLGHTITQGPK- 4022

  Fly   422 HCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEF 486
                            |:|:           |..:..||....|....                 
Zfish  4023 ----------------TVDV-----------PASLPTPPHNNQEDLRG----------------- 4043

  Fly   487 TESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDK 551
             :...|:.:|..|:                   :....|..|   :|..:..|.|   |||.|: 
Zfish  4044 -QEHCIDRDTPDSF-------------------VPSSSPESV---VGMEISRYPD---LSRVKE- 4081

  Fly   552 GVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASE-KVWEDVHAASRDFIQ 615
                         ||...|            .:..:|..|    |:.|| :.||.......:|..
Zfish  4082 -------------EPPSPA------------VSPVIPILD----CKGSEARRWEVKTEPPSNFFA 4117

  Fly   616 KYVEKYSVDRPMVQCTRGQ----SMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSL 676
            ....:.|.      |.|..    |:|...........|:....:::.:...|:       |..:.
Zfish  4118 SQFGQLST------CLRTDLVPVSITLNPVAAMNIQGVVSALANMLCVSIPGN-------YEVTR 4169

  Fly   677 RLGPVFRETQNNMNSSSAQQLRVPRRT-----EPFIRYTK--------------------EMESS 716
            ..||..|.:.:.::.     |:||..|     :|.:|..:                    :|..|
Zfish  4170 SPGPEHRSSIDMLSG-----LKVPHPTSLFHQQPGMRLHRPPLPHQTFSDGTAMVRRDYGQMHGS 4229

  Fly   717 S---------------------------KVNQQMRAFARKSSASAQNNALA--AASSAATPAGGR 752
            |                           .:|:.....|.:|.....||.|.  :||..:....|:
Zfish  4230 SLGSKPQWCSHCRVVVLGNGVRKSTKELPMNKLGHGGAVESLVFCSNNCLVLYSASMQSKLLDGK 4294

  Fly   753 TNAGGVSTS----NSASAVRHLNNSTIYVD---------DENRPKGHVVYFTAKRNLPPKMYKCH 804
            .|....|.|    |....:...||:...:|         .::.|...::.|.   ::..:|.: .
Zfish  4295 PNFPPPSESGDKQNPTKVLHQYNNNISDLDVHCLAQLQPKQSPPPTPIISFP---SITSEMLR-G 4355

  Fly   805 ECSPNCLFKIVHRLDSYSPLAKP-------------LLSG--WERLVMRQKTKKSVVYKG----- 849
            :|.|:.| |:..:|       ||             .|||  |:.|..|:.:.:.:|.||     
Zfish  4356 DCKPDTL-KVTVKL-------KPRPRAVHNGGDEPRYLSGKRWKALRWRRWSVQIIVPKGNYHLP 4412

  Fly   850 -------------------PCGKSLRSLAEVHR----YLRATENVLNVDNFDFTPDLKCLAEYSI 891
                               |..|.:|.....|.    .......:||:| .|....|.| |.:| 
Zfish  4413 VEEEIDALLKKLGTSLRPEPMPKDMRRCCFCHEEGDGLTDGPARLLNLD-LDLWVHLNC-ALWS- 4474

  Fly   892 DPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVH-LNLDEEFLLCCDCEDDCS 955
                   |::.:.|....|.:.......|...|.|.:|...|.|.| |.....:...|..:..|:
Zfish  4475 -------TEVYETQAGALINVELALRRGLSVRCAYCQQTGATSGCHRLRCTNAYHFTCALKAQCT 4532

  Fly   956 ---DKS-----------------------KCACW------------------------------- 963
               ||:                       :..|:                               
Zfish  4533 FFKDKTMLCHLHRPRGTSLIGGGLLGTEHELRCFAVFRRVYVQRDESRQIASIIQRGEREHTFRV 4597

  Fly   964 -QLTVAGVRYCNPKK--------PIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSL 1019
             .|.:..|....|::        .|..:||:..|::..:..|...|:..|...:|      ..|.
Zfish  4598 GSLVLHAVGQLLPQQMLAFHSMTAIFPVGYEASRIYWSMRHGNRRCHYVCSINEN------DGSP 4656

  Fly  1020 EMKLQVFKTSNRGW-GLRCVNDIPKGAFICIYAGHLLTETMA---NEGG-------QDAGDEYFA 1073
            |..::|.:   :|: .|......|||.:      ..:.|.:|   ||.|       ...|::.|.
Zfish  4657 EFVIRVVE---QGYDDLILTGSSPKGVW------DKVLEPVAERRNETGFLRLFPVYLKGEDLFG 4712

  Fly  1074 -----------DLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRS 1127
                       .|..:|..|:....|........|.|...:|...:|.    :...|.:|.:.|.
Zfish  4713 LTVSAVTRIVESLPGVEACERYTFRYGRNPLMQLPLAINPSGCARSEP----KACTHIKRFVLRP 4773

  Fly  1128 SRSGST-----------------------QNSSTQSSELDSQERA-------------------- 1149
            ....||                       .:.|.|...::::.::                    
Zfish  4774 HTLTSTSKALQSPGNPAEIGVPPYSKHFVHSKSAQYRRMNAEWKSNVYLARSRIQGLGLYAARDI 4838

  Fly  1150 -----VINF------NPNADLDETVRENSVRRLF-GKDEAPYIMDAKTTGNLGRYFNHSCSPNLF 1202
                 ||.:      :..|:..|.:.|...|.:: .:.::.:::||..||...||.||||:||..
Zfish  4839 EKYTMVIEYIGTIIRSEVANRKEKMYEAQNRGVYMFRIDSEHVIDATITGGPARYINHSCAPNCI 4903

  Fly  1203 VQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
            .:.|.::    |...:...|...|:.|.||.::|.:::.....|: .|.|||.|||
Zfish  4904 TEVVALE----RGHKIIISSNRRIQRGEELCYDYKFDLEDDQHKI-PCHCGAVNCR 4954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 HMT_MBD 823..879 CDD:238689 18/98 (18%)
Pre-SET 901..1013 CDD:282838 26/178 (15%)
SET 1022..1239 CDD:214614 54/293 (18%)
kmt2caXP_005162602.1 PHD_SF 263..346 CDD:304600
PHD1_KMT2C_like 360..404 CDD:276984
PHD2_KMT2C 406..451 CDD:277069
PHD_SF 484..535 CDD:304600
PHD4_KMT2C 973..1029 CDD:277071
PHD5_KMT2C_like 1030..1076 CDD:276988
PHD_SF 1108..1157 CDD:304600
HMG 1707..1760 CDD:197700
CITED 2586..>2683 CDD:282356
ePHD2_KMT2C 4440..4544 CDD:277167 24/113 (21%)
FYRN 4599..4649 CDD:283589 10/49 (20%)
FYRC 4656..4736 CDD:283590 17/88 (19%)
SET 4819..4940 CDD:214614 26/124 (21%)
SET <4820..4958 CDD:225491 34/140 (24%)
PostSET 4942..4958 CDD:214703 8/14 (57%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593851
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.930

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