DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and setd1a

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_001920852.4	Gene:	setd1a / 556535	ZFINID:	ZDB-GENE-080521-4	Length:	2253	Species:	Danio rerio

Alignment Length:	1346	Identity:	222/1346 - (16%)
Similarity:	381/1346 - (28%)	Gaps:	498/1346 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PVRKGENSLESPAEQAAKDVEIEELTHSEAIAATGSTRKQC------PY-------------GGK 80
            |..:.|:|.:..:..||..     .|....:|..|:.|::.      ||             ..:
Zfish  1280 PDEEDEDSYQGKSADAAAG-----RTEERRVAERGAARRRSRAKARKPYELDSEGEETSDGSSSE 1339

  Fly    81 APDEPGKLADESEDRKGENTKAIASSPVLVAVDSDSSVELIES----PVKFSSANESEKDPPKPD 141
            ..||.....|||||.               |:.:||..|.:.|    ....|||:.|..|....:
Zfish  1340 KEDEDSDKVDESEDE---------------ALSADSDDESVSSSSSESSSSSSASSSSSDEEDEE 1389

  Fly   142 AVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGMEVDQDVEES------------ 194
            ...:||..|:.:..|.|.....:....||||:.....:|  |.:...:|.:|.
Zfish  1390 EGEQAAESESLDTMDESTMDSVAAVDTEKDERDKASLDQ--PSVTTPEDKQEEEKSATPVPPSSP 1452

  Fly   195 ISRPAEEYKIENTLKGHKRISLTEIEEHKI----------------VDKKDD----VLEVELEKG 239
            ..||:....:...||..::.....:||.::                |.:..|    |..|.....
Zfish  1453 YPRPSSPILLLPPLKKRRKTVSFSMEESEVKPSVQSSTASSPSPSPVSQASDVPPSVSPVSTPTP 1517

  Fly   240 TAPKA---------------AEDEKLNALLSDGDVFYDKECVNC--------------------- 268
            .||.|               :|...|.:..|...:......|..
Zfish  1518 AAPSASSKPVPMLLPFASRPSESSALTSPASPSAILTVPPPVRSLRPDEPKKSPGPPPSPQTPPP 1582

  Fly   269 -NCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMD-------LYEE-------YAGQ 318
             |.||..|.......|.               :|:...:..:|       .||:       ..|:
Zfish  1583 KNSTKRGKDSPRTPPAP---------------VCLTVQNLPLDHASMVKMAYEDPVPLPTTQKGR 1632

  Fly   319 LMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFT 383
            ...:...|.:.....|. ..||:..||:|||.:        .:|:|.|.         |......
Zfish  1633 ARGRPRTLSQSASASHL-HPALEEEDEDEEELE--------QRLKLREQ---------LGVSSLL 1679

  Fly   384 AQLSWSKTILQAKADHLERQFALADVELEKVQTTADKMHCALYNSCPVAHKHLPTLDIEPSDYVH 448
            ...|..|..|...||...:....||::.|:.:|:.:            |.:|  .|:.|..|:.
Zfish  1680 QLASAPKPDLSVLADVALKMDPEADIDSEETETSDE------------AEEH--KLEEEEGDFF- 1729

  Fly   449 EVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMIK 513
             .|.|    |.|:...|..:.::.                                    :...|
Zfish  1730 -APHP----RQPLLDPEGLFVMQE------------------------------------HNYSK 1753

  Fly   514 TVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIF 578
            |...:||.    ||.:.|                 |....|       ::...|.|..
Zfish  1754 TPAPQHIT----PPQKKT-----------------KQDSTV-------LLPADLNQHG------- 1783

  Fly   579 YDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGT 643
                            |.:|.|:|                             .|:::...:...
Zfish  1784 ----------------VQEAPEEV-----------------------------IGEALAARAEAP 1803

  Fly   644 WLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIR 708
            .||.     |..|:....|..:..|:.:.....|.|.:.:|.:.........:.|..:..|....
Zfish  1804 ELYG-----DLDLLCDGREAAETQTKTLSSPYKRTGSISKEVELEERGKGKNKKRSRKDKENEEL 1863

  Fly   709 YTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNS 773
            .|.:.:...:|.:|.:....:.........|.:...::            |||:|..:...|..|
Zfish  1864 QTSKKQKEKQVKKQKKRKLEEFEEDVDVEQLESGELSS------------STSDSGDSDFGLERS 1916

  Fly   774 TIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMR 838
            ..:..:|.|....:  |..:..|.|...:..:.:|..|           |:.:|  |...|....
Zfish  1917 LEFEKEEVRKSERL--FLQEAGLTPSTQRRPKHTPESL-----------PIPRP--SYKNRSEFE 1966

  Fly   839 QKTKKSVVYKGPCGKSLRSLAEVHRYLRAT-ENVLNVDN-FDFTPDLKCLAEYSIDPSIVKDTDI 901
            |.|....::.....:      |..|.|::| |.:|..|: .|:..|...:      |..:.:...
Zfish  1967 QMTILYDIWNSGLDQ------EDMRLLKSTYEKLLQDDHGTDWLNDTHWV------PHTITNIPN 2019

  Fly   902 SKGQEKMAIPLVNYYDNTLPPPCT--------YAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKS 958
            .:.::|.|       |..|....|        ||..| ..:.|:|.||:...|....:.|.:..:
Zfish  2020 PRRKKKTA-------DGQLREHVTGCARSEGYYAISR-KEKDVYLELDQPVTLREIGDYDTAGSN 2076

  Fly   959 KCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVP----TGIYECNSRCKCKKNCLNRVVQFSL 1019
            :       |...|....::.:..||         .|    :.:.:.| :.|.:|.
Zfish  2077 R-------VLSERRSEQRRLLSAIG---------TPAVMDSDLLKLN-QLKFRKK---------- 2114

  Fly  1020 EMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQL 1084
              ||:..::....|||..:..|.....:..|.|..:.:.:|     |..::.:|.       |.:
Zfish  2115 --KLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQSIRQMVA-----DNREKRYAQ-------EGI 2165

  Fly  1085 KEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERA 1149
            ...|...|||..
Zfish  2166 GSSYLFRVDHDT----------------------------------------------------- 2177

  Fly  1150 VINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLR 1214
                                          |:||...|||.|:.||.|:||.:.:.:.:::...
Zfish  2178 ------------------------------IIDATKCGNLARFINHCCTPNCYAKVITIESQKK- 2211

  Fly  1215 FPWVAFFSAAHIRSGTELTWNYNY--EVGVVPGKVLYCQCGAPNCR 1258
               :..:|...|....|:|::|.:  |...:|     |.||..:||
Zfish  2212 ---IVIYSKQPIGVNEEITYDYKFPIEENKIP-----CLCGTESCR 2249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	13/57 (23%)
		Pre-SET	901..1013	CDD:282838	22/123 (18%)
		SET	1022..1239	CDD:214614	33/218 (15%)
setd1a	XP_001920852.4	RRM_Set1A	89..183	CDD:240992
		DUF3729	<1504..1563	CDD:315239	10/58 (17%)
		N-SET	1969..2108	CDD:314603	31/175 (18%)
		SET	2114..2237	CDD:214614	34/233 (15%)
		PostSET	2237..2253	CDD:214703	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930