DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and nsd1a

DIOPT Version :9

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:XP_683890.4 Gene:nsd1a / 556086 ZFINID:ZDB-GENE-080519-3 Length:2055 Species:Danio rerio


Alignment Length:1516 Identity:283/1516 - (18%)
Similarity:475/1516 - (31%) Gaps:571/1516 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GQPTAVDCLESS---GSTVED-----------VQETPASREKSYG-----LPVRKG--ENSLESP 46
            |:.|.|.||::|   .||.:|           ...:|.|.:.|:.     ||...|  ..:|.:.
Zfish   555 GKKTDVKCLKNSKLKKSTPKDKTLKATSSRLKESSSPGSSDGSFAMHSHYLPASSGLIVRALAAG 619

  Fly    47 AEQAAKDVEIEELTHS----------------------------EAIAATGS---------TRKQ 74
            .|...||:..|..:||                            |::.|:.|         .:|:
Zfish   620 EETKEKDLSHEPNSHSPSSEHSSQTNHELSKQNWEVKNNSESSEESVDASDSPPNPTSIKRIKKR 684

  Fly    75 CPYGGKAPDEPGKLADESEDRK------GENTKAIASSPVLVAVDSDSSVELI------------ 121
            ....|...|.|.|..:|||.:.      .:.:.:...||.:..:|:...::.:            
Zfish   685 PQKNGIHKDPPPKSHEESESKVNNESMFSDTSSSSIPSPSISPMDAFQDIKELSFRSLVKEECSS 749

  Fly   122 -ESPV------KFSSANESEKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKENE 179
             |||:      |||:.....||      ::::..||.:.:|    ..|||.|...|:|.:.....
Zfish   750 GESPLRADSNYKFSTFLMLLKD------LHDSREKEGKPLT----LPPTSPSSLIKEEPSLIPVG 804

  Fly   180 QEPPGMEV--DQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHK----IVD-----KKD---- 229
            :|||. ||  :::..|..|.|.:.....|:.:...::..|..:|.:    ::|     ||.    
Zfish   805 EEPPN-EVLCEKEFAEQSSLPGKTSTPNNSKQSKAKLKSTVKKESQKPDVVIDSVSPLKKPISPV 868

  Fly   230 --DVLEVELE-KGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVL 291
              |||:..|. .|..||:::   ::|.::|            .|.|.....|........|...|
Zfish   869 GLDVLDKSLPLLGDLPKSSD---VSAAVTD------------VCAKGTISKVAPKKRWKTFESEL 918

  Fly   292 RKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSD 356
            .||.|.:      .|......:|.  :.::.:|           :.|..|...|......|.|.|
Zfish   919 GKSIKPK------SDQVDSTLDEV--KSVSTEP-----------NGVFKDGLQESAHSDVPNKKD 964

  Fly   357 FSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTADKM 421
            .|:||      .|....|.::...:...|:..||...:...:..:....:::...|  |..:|::
Zfish   965 ASENK------RLRKPSKRLIECGEEYEQIFPSKKKTKKSTESCKTGSCISNTTPE--QPASDQI 1021

  Fly   422 HCALYNSCPVAHKHLPTLDI-------EPSDYV--HEVPPPGEIVRPPIQLGETYYAVKNKAIAS 477
                            |||.       :|.|:|  .|..||.:::.||       .|.|:.:.|:
Zfish  1022 ----------------TLDAVSSSSAEKPLDHVVAEEQKPPADVLVPP-------SAPKSPSCAT 1063

  Fly   478 WVSI----------------KVIEFTESTAINGNTMKSYK----IRYLNTPYQM-IKTVTAKHIA 521
            .:..                |.:......||.|.::|..|    .::...|.:. ::.:..:..|
Zfish  1064 SLETEPCEKKSAPLERKRPRKSVHKVLDCAIEGESVKIPKKGESRQHKTNPEESGVRDLEKQEEA 1128

  Fly   522 YFEPPPVRLTIGTRVIAYFDG---TTLSRGKDKGVVQSAFYPGIIAEPLK-QANRYRYLIFYDDG 582
              .|||   :....|.|..:|   |:.....|...|......|..:.|.| |.|....||  .:|
Zfish  1129 --GPPP---SSPCAVSAQSEGELRTSSPIQPDVPSVSQIPVEGEQSSPSKPQINNEDSLI--SEG 1186

  Fly   583 YTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRGQSM------TTESN 641
            :...:                .|...:|||.:...:...|.::..|:...|.|:      ..|..
Zfish  1187 FAAGL----------------NDSAFSSRDSLSGDLSGLSTNKRSVERGGGASLKENVCQVCEKT 1235

  Fly   642 GTWLY---------------------ARVIDIDCSL-----------------VLMQFEGDKNHT 668
            |..|.                     .|.|..:|.:                 .::...|...|.
Zfish  1236 GELLLCEGQCCGAFHLQCIGLTETPKGRFICQECKMGVHTCFVCKKPDKEVRRCMIPVCGKFYHM 1300

  Fly   669 EWIYRGSLRLGPVFRETQ--------------NNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKV 719
            :.|    |:..|...:.:              .|.|:....:.|:.|.....:.|        ..
Zfish  1301 DCI----LKYSPTVAQNRGFRCSIHVCLSCYITNPNNPGISKGRLTRCVRCPVAY--------HA 1353

  Fly   720 NQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPK 784
            |....|   ..|....||:....:. .||..|..|.            .|:|.|..:|..|.   
Zfish  1354 NDYCMA---AGSVPLANNSFLCPNH-FTPRKGCKNH------------EHINVSWCFVCSEG--- 1399

  Fly   785 GHVVYFTA----------KRNLPPKMYKCHECS-------------------------------P 808
            |.::...:          ...:|...:.|::|.                               |
Zfish  1400 GSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVP 1464

  Fly   809 NCLFKIVHRLD--------------SYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLA 859
            ..:.::.|.:.              :|.....|.:.|......:.......|||    |:|...|
Zfish  1465 ENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKGADAVYK----KALNEAA 1525

  Fly   860 EVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPC 924
            :..|                              .::|:.::.:.||       :..::..|||.
Zfish  1526 DRFR------------------------------ELLKEKEMRQLQE-------DRKNDKKPPPY 1553

  Fly   925 TYAKQRIPTEGVHLNLDEEFLLC--------CDC----EDDCSDKSKCACWQLTVAGVRYCNPKK 977
            .:.|       |:..:.:..::.        |:|    |:.|...|:|....|            
Zfish  1554 KHIK-------VNKQIGKVLIITADLSEIPRCNCKATDENPCGIDSECINRML------------ 1599

  Fly   978 PIEEIGYQYKRLHEHVPTGIYECNSR-CKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDI 1041
                               :|||:|: |...:.|.|:........::::|:|.:||||||.::||
Zfish  1600 -------------------LYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDI 1645

  Fly  1042 PKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGP 1106
            .||||:..|.|.::.|.                    |...::|                     
Zfish  1646 KKGAFVNEYVGEVIDEE--------------------ECRSRIK--------------------- 1669

  Fly  1107 DAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRL 1171
            :|:|:|                                     :.||. ...||           
Zfish  1670 NAQDND-------------------------------------ICNFY-MLTLD----------- 1685

  Fly  1172 FGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNY 1236
              ||.   |:||...||..|:.||||.||...|...|: .|.|   |..|:...|..|.|||:||
Zfish  1686 --KDR---IIDAGPKGNESRFMNHSCQPNCETQKWTVN-GDTR---VGLFALEDIPKGVELTFNY 1741

  Fly  1237 NYEVGVVPGKVLYCQCGAPNC 1257
            |.|. :..||.: |:||||||
Zfish  1742 NLEC-LGNGKTV-CKCGAPNC 1760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 HMT_MBD 823..879 CDD:238689 9/55 (16%)
Pre-SET 901..1013 CDD:282838 20/124 (16%)
SET 1022..1239 CDD:214614 54/216 (25%)
nsd1aXP_683890.4 PWWP 285..382 CDD:295359
TNG2 <1108..1270 CDD:227367 32/184 (17%)
PHD1_NSD1_2 1228..1270 CDD:277118 5/41 (12%)
PHD_SF 1275..1321 CDD:304600 5/49 (10%)
PHD3_NSD1 1322..1375 CDD:277123 10/63 (16%)
PHD4_NSD1 1392..1431 CDD:277126 5/41 (12%)
WHSC1_related 1437..1531 CDD:99899 12/127 (9%)
AWS 1574..1624 CDD:197795 14/80 (18%)
SET 1626..1748 CDD:214614 55/221 (25%)
PHD5_NSD1 1802..1844 CDD:277129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593784
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.930

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