DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and KMT2A

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_011541131.1	Gene:	KMT2A / 4297	HGNCID:	7132	Length:	4005	Species:	Homo sapiens

Alignment Length:	1694	Identity:	296/1694 - (17%)
Similarity:	508/1694 - (29%)	Gaps:	658/1694 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGQPTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKD------VEIEEL 59
            |.|.|.|.. ::..||..|  .:.|..|.....|...|.||  ||.::.|.|:      ::||..
Human  2530 MPGVPKAPP-MQVEGSAKE--LQAPRKRTVKVTLTPLKMEN--ESQSKNALKESSPASPLQIEST 2589

  Fly    60 THSEAIAAT-----GSTRKQCPYGGKA--------------------PDEPGKLADESEDRKGEN 99
            :.:|.|:|:     |...:..|.....                    ||.|....|.|..|:...
Human  2590 SPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPR 2654

  Fly   100 TKAIASSPVLVAVDSDSSVELI-ESPVKFSSANESEKDPPKP-----DAVNEAAAKEAEEM---- 154
            ..|.|.|.:...:.....|... |..:.|.|::..:|...:.     |..::.:..:.:::
Human  2655 RSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYN 2719

  Fly   155 -TDSSISSPTSES------FPEKDE-----------------------KTNKENEQEPPGMEVDQ 189
             |.:.|||...|.      |.|:::                       .|.:::.|.|.....:.
Human  2720 FTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKEN 2784

  Fly   190 DVEE-SISRPAEEYKIENTLK---GHKR---------ISLTEIEEHKIVDKKDDVLEVEL----- 236
            ..|. .|.||.:..:.|:..|   |||.         :|       ::..:..|.||.:|
Human  2785 GTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVS-------RVKTQGQDSLEAQLSSLES 2842

  Fly   237 EKGTAPKAAEDEKL------NALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSS 295
            .:........|:.|      ..|.||.|.....:|.|...:.: ..:||.|..::.......:||
Human  2843 SRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDI-MDFVLKNTPSMQALGESPESS 2906

  Fly   296 KQQFLCMG-------CHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPE 353
            ..:.|.:|       ..:..|.|:|.::.||...:|:          |.....|...||:.:.|.
Human  2907 SSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPV----------DSSVSSSISAEEQFELPL 2961

  Fly   354 K--SDFS-------------KNKLQLIED----------------ELDDAI-------------- 373
            :  ||.|             .::|.:|.|                |.|.|:
Human  2962 ELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMT 3026

  Fly   374 ------------------------------------------------------KNVLNKVDFTA 384
                                                                  |.|.|..|...
Human  3027 PDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPG 3091

  Fly   385 QLSWSKTILQAKADHLERQF-----------------ALADVELEKVQTTAD------------- 419
            ....|...:|....||:...                 .|.:...:|:|.|:.
Human  3092 PSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS 3156

  Fly   420 ---------KMHCALYNSCPVA----------------HKHL------------PTLDIEPSDYV 447
                     .:...|..|.|.:                |:||            |.:...||..:
Human  3157 VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLL 3221

  Fly   448 HEVPPPGE------------------------IVRPPIQLGETYYAVKNKAIA----------SW 478
            ..|.||.:                        :.:.||...:|.   |||.:|          |.
Human  3222 IGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTR---KNKKLAPSSTPSNIAPSD 3283

  Fly   479 V--SIKVIEFTESTAINGNTMKSYKIRYLNT-PYQMIKTV---TAKHIAYFEPPPV--------- 528
            |  ::.:|.||.|...|..::  ..:..||| .::.:..:   :...|.||||.|:
Human  3284 VVSNMTLINFTPSQLPNHPSL--LDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTA 3346

  Fly   529 RLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIA-----EPLKQANRYRYLIFYDDGYTQYVP 588
            ....||..|:. |.:.|:.|...|:..|:....:::     .|...|:           ...:|.
Human  3347 ATAAGTSTISQ-DTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSAS-----------VPGHVT 3399

  Fly   589 HRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSV-DRPM-VQCTRG---QSMTTESNGTWLYAR 648
            ..:.||:..      .|:.:.|...|:...:...: |:|: :..:.|   |..|:::..|.....
Human  3400 LTNPRLLGT------PDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITA 3458

  Fly   649 VIDIDCSLVLMQF----------EGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRT 703
            ...| |.|...|.          |.|:::........|........:|.:::|:|..|:.
Human  3459 ASSI-CVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVS----- 3517

  Fly   704 EPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVR 768
                .:|:.::            |..|....||.||::|..|:.     |:.|| |.|:.:|..|
Human  3518 ----NFTQTVD------------APNSMGLEQNKALSSAVQASP-----TSPGG-SPSSPSSGQR 3560

  Fly   769 HLNNSTIYVDDENRPKGHVVYFTAKRNLP--PKMYKCHECSPNCLFKIVHRLDSYSPLAKP---- 827
            ..:.|   |....:||..    |.:..||  ....|.|        |:.|...|.|....|
Human  3561 SASPS---VPGPTKPKPK----TKRFQLPLDKGNGKKH--------KVSHLRTSSSEAHIPDQET 3610

  Fly   828 --LLSG----------WERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFT 880
              |.||          .:...:.|.::|.      ||:....:| |...::.|:|..|
Human  3611 TSLTSGTGTPGAEAEQQDTASVEQSSQKE------CGQPAGQVA-VLPEVQVTQNPAN------- 3661

  Fly   881 PDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGV--HLNLDEE 943
                  .:.|.:|..|::.     :...:.||:.:.........:..::: |.:|:  .::.|:.
Human  3662 ------EQESAEPKTVEEE-----ESNFSSPLMLWLQQEQKRKESITEKK-PKKGLVFEISSDDG 3714

  Fly   944 FLLCCDCEDDC----SDK-----SKCACWQLTVAGV----------------------------- 970
            |.:|.:..:|.    :||     |.....||:.|||
Human  3715 FQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNY 3779

  Fly   971 --RYCNPKK----PIEEIGYQYKRLH--------------------EHVPTGIYECNSRCKCKKN 1009
              |:..|::    |:...|.....:|                    |:.|....|...:.|..:
Human  3780 KFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR- 3843

  Fly  1010 CLNRVVQFSLEMKLQ-------------VFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMAN 1061
               |.....|.|.::             |:::...|.||.|..:|..|..:..|||:::.....
Human  3844 ---RATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQT- 3904

  Fly  1062 EGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKR 1126
                |..::|:                             |:.|...         |.::
Human  3905 ----DKREKYY-----------------------------DSKGIGC---------YMFR----- 3922

  Fly  1127 SSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGR 1191
                            :|..|                                ::||...||..|
Human  3923 ----------------IDDSE--------------------------------VVDATMHGNAAR 3939

  Fly  1192 YFNHSCSPNLFVQNVFVD--THDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGA 1254
            :.||||.||.:.:.:.:|  .|      :..|:...|..|.|||::|.:.:.....| |.|.|||
Human  3940 FINHSCEPNCYSRVINIDGQKH------IVIFAMRKIYRGEELTYDYKFPIEDASNK-LPCNCGA 3997

  Fly  1255 PNCR 1258
            ..||
Human  3998 KKCR 4001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	13/71 (18%)
		Pre-SET	901..1013	CDD:282838	25/177 (14%)
		SET	1022..1239	CDD:214614	37/231 (16%)
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2061..2107	CDD:283589
		FYRC	3705..3788	CDD:197781	14/82 (17%)
		SET	<3861..4005	CDD:225491	45/244 (18%)
		SET	3867..3987	CDD:214614	37/221 (17%)
		PostSET	3989..4005	CDD:214703	8/14 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930