Protein Alignment egg and ehmt1b

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_021324462.1
• Gene: ehmt1b / 402830
• ZFINID: ZDB-GENE-080515-3
• Length: 1295
• Species: Danio rerio
• Alignment Length: 1368
• Identity: 293/1368 - (21%)
• Similarity: 457/1368 - (33%)
• Gaps: 443/1368 - (32%)

  Fly     2 SGQPTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQA------AKDVEIEELT 60
            :|:|.||   :...|.:::  :.|.|:..:..:|     |:  :||:..      |..||...::
Zfish   225 AGKPEAV---QPQPSLIQN--QLPQSQTDATSVP-----NT--TPAKPQIEFSLYASTVEPRPVS 277

  Fly    61 HSEAIAATGSTRKQCPYGGKAPDEPGKLADESEDRKGENTKAIASSP------VLVAV-----DS 114
            .|.|..:....||...| ...|.:..|:..:....  |..:.|:.||      .:|.|     |:
Zfish   278 PSVAAVSRKKKRKMGTY-SLVPKKKNKVLKQRTVL--EMFQQISQSPPNPKPKEIVRVNGEKMDN 339

  Fly   115 DSSVELIESPVKFSSANESEKDPPKPDAVNEAAAKEA-EEMTDSSISSPTSESFPEKDEKTNKEN 178
            :|..|         .:.|.|....:.:.|.|..||.: ||....|||.|..|   |.:|..:.|.
Zfish   340 ESDEE---------ESEEGEDTEDEEELVTEDGAKASHEEPRIPSISQPLEE---ESEESQDCEG 392

  Fly   179 EQEPPGMEVDQDVEESIS--------------RPAEEYKIENTLKGHK-RISLTEIEE------- 221
            |:|  |.|.|...|.|:.              ||:.:.|.:...|..| ...:|||:.
Zfish   393 EEE--GDESDLSSESSLKKKWKKKAKGDHAWLRPSRKRKRKWKAKTDKVSAPVTEIQSRPESQSA 455

  Fly   222 ------HKIVDKKDDVLEVELEKGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQYVLA 280
                  |:...|:..:..:.|....|...:::...:..|...|....:|...|:|
Zfish   456 PSVPTAHRKEYKEVPLDSLNLAAQEALLTSQNTAASGSLQSTDADMVQELPLCSC---------- 510

  Fly   281 NMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDE 345
            .|.|....::|..:.::   ||..        |...|||...|..:||......::.|.|....|
Zfish   511 RMETPKSREILTLADRK---CMAT--------ESIDGQLSRCQSAVLKHEMMRPSNSVQLLVLCE 564

  Fly   346 EEE----------------------EKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFT----A 384
            :..                      |.|||.:         |.........:|||...|.    .
Zfish   565 DHRTGMVKHQCCPGCGFFCRAGTFMECQPEVN---------ISHRFHRTCASVLNGQSFCPHCGE 620

  Fly   385 QLSWSKTILQAKADHLERQFALADVELEKVQTTADKMHCALYNSCPVAHKHLPTLDIEPSDYVHE 449
            ::|.:|.:..||||                 ||         ::.|:.|...
Zfish   621 EVSKAKEVTIAKAD-----------------TT---------STVPITHSSC------------- 646

  Fly   450 VPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMIKT 514
            :|...|........|.|..:|..:..|:....|..| ::.|:::....|:..:.....|...:
Zfish   647 IPSTSEGKADTTTGGSTRLSVLGEGKANSTLPKPSE-SQDTSLSLVGSKARSVAMAAAPGLPL-- 708

  Fly   515 VTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIFY 579
                     .|.|.:.|:.:.::|      |...|.|   :..|:|..:....||....:.|:..
Zfish   709 ---------PPGPPKETLQSVLLA------LDAEKPK---KLRFHPKQLYISAKQGELQKVLLML 755

  Fly   580 DDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTW 644
            .||.       |.....::..| ...:|.|:....|      .|...:||......|..|...|.
Zfish   756 VDGI-------DPNFKMESQNK-RTPLHVAAEAGHQ------DVCHMLVQAGANLDMCDEDQRTP 806

  Fly   645 LYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIRY 709
            |...     |         :.||.|.: |..||.|.:...
Zfish   807 LMEA-----C---------ENNHLETV-RYLLRAGAIVSH------------------------- 831

  Fly   710 TKEMESSSKVNQQMRAFARKSSASAQNNALAAAS---SAATPAGGRTNAGGVSTSNSASAVRHLN 771
             |::|.|:.::           .:|:|...:...   ||........:.||.:....|:..:|::
Zfish   832 -KDVEGSTCLH-----------LAAKNGHFSIVQHLLSAGLVDINCQDDGGWTAMIWATEYKHVD 884

  Fly   772 --------NSTIYVDDENRP--------KGHV----VYFTAKRNLPPKMYKCHECSPNCLFKIVH 816
                    .:.|.:.|:...        .|.|    ::.|||.:|  .....|..||..:.....
Zfish   885 QVKLLLSKGADINIRDKEENICLHWAAFSGCVEIAEIFLTAKCDL--NTMNIHGDSPLHIASREG 947

  Fly   817 RLDSYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSL---------RSLAEVHRYLRATENVL 872
            |||..:..   |..|.:   :..|.|:.......|..|.         :...|.:|...|||.:|
Zfish   948 RLDCVNLF---LSRGAD---VNLKNKEGETPMECCSHSSKVWNALQANKKQREANRKAGATEKLL 1006

  Fly   873 NVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGV- 936
            |                         .||::|.||:.:|.||..|:   .||....:.:|...|
Zfish  1007 N-------------------------KDIARGYEKVPVPCVNAVDS---EPCPDNYKYVPDSCVT 1043

  Fly   937 -HLNLDEEF--LLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIY 998
             .||:|:..  |..|.|:||||..| |.|.||::. ..|....:.:.|..      :|..|. |:
Zfish  1044 SPLNIDKNITHLQYCVCKDDCSSAS-CMCGQLSLR-CWYDKESRLLPEFS------NEEPPL-IF 1099

  Fly   999 ECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEG 1063
            |||..|.|.:.|.|||||..|..:||:|||...|||::.:.|||:|.|:|.|.|.:::
Zfish  1100 ECNHACSCWRTCKNRVVQNGLRTRLQLFKTQMMGWGVKTLQDIPQGTFVCEYVGEIIS------- 1157

  Fly  1064 GQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSS 1128
                                              |||.|
Zfish  1158 ----------------------------------DAEAD-------------------------- 1162

  Fly  1129 RSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEA---PYIMDAKTTGNLG 1190
                                              ||||. ..||..|..   .|.:||:..||:.
Zfish  1163 ----------------------------------VREND-SYLFSLDSKVGDMYCVDARFYGNIS 1192

  Fly  1191 RYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAP 1255
            |:.||.|.|||....||....|||||.:|||:..:|.:|.||.::|......|.||:..|:||:.
Zfish  1193 RFINHHCEPNLLPCRVFTSHQDLRFPHIAFFACKNISAGDELGFDYGDHFWDVKGKLFNCKCGSS 1257

  Fly  1256 NCR 1258
            .|:
Zfish  1258 KCK 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	16/89 (18%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	12/53 (23%)
		HMT_MBD	823..879	CDD:238689	13/64 (20%)
		SET_SETDB1	900..1262	CDD:380915	106/366 (29%)
ehmt1b	XP_021324462.1	EHMT_ZBD	503..632	CDD:411018	29/158 (18%)
		ANKYR	720..973	CDD:440430	60/335 (18%)
		ANK repeat	739..765	CDD:293786	6/32 (19%)
		ANK repeat	767..800	CDD:293786	8/39 (21%)
		ANK repeat	802..833	CDD:293786	10/71 (14%)
		ANK repeat	835..867	CDD:293786	6/42 (14%)
		ANK repeat	869..900	CDD:293786	5/30 (17%)
		ANK repeat	902..933	CDD:293786	6/32 (19%)
		ANK repeat	935..966	CDD:293786	8/36 (22%)
		SET	1033..1262	CDD:394802	95/339 (28%)