DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and Set1

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001015221.1	Gene:	Set1 / 3354971	FlyBaseID:	FBgn0040022	Length:	1641	Species:	Drosophila melanogaster

Alignment Length:	1574	Identity:	290/1574 - (18%)
Similarity:	499/1574 - (31%)	Gaps:	489/1574 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKDVEIEELT-HSEAIA--------- 66
            |.:|..::|:..|..:.|    :|.|..:.:.....|: .:|...:|.: ||...:
  Fly   226 EKNGEHIKDIYTTQTNHE----IPNRSRDRNWNRDKER-ERDRHFKERSRHSSERSYDRDRGMRE 285

  Fly    67 --ATGSTRKQCPYGGKAPD-EPGKLADESEDRKGENTKAIASSPVLVAV-----DSDSSVELIES 123
              .|...|::..|..::.| .|    ::|.|             :|:..     ||||      .
  Fly   286 NVGTSIRRRRTFYRRRSSDISP----EDSRD-------------ILIMTRERSRDSDS------R 327

  Fly   124 PVKF--SSANESEKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGM- 185
            |..:  |...||.:|..:.   :|....:..|..:...:|.....:..:|...:.|.:|...|.
  Fly   328 PRDYCRSRERESFRDRKRS---HEKGRDQPREKREHYYNSSKDREYRGRDRDRSAEIDQRDRGSL 389

  Fly   186 ----------EVDQDVEESISRPAEEYKIENTL----KGHKRISLTEIEEHKI-VDKK------D 229
                      .::.||..| |.....|...::|    .|....|...||..|. .|::      .
  Fly   390 KYCSRYSLHEYIETDVRRS-SNTISSYYSASSLPIASHGFNSCSFPSIENIKTWSDRRAWTAFQP 453

  Fly   230 DVLEVELEKGTAPKAAEDEKLNALLSDGDVFYDKECV---NCNCTKLHKQYVLANMATLNFYQVL 291
            |...|:      |.....|:::   :..:..:||..:   :..|....:..|.:|   :||...|
  Fly   454 DFHPVQ------PPPPPPEEID---NWDEEEHDKNSIVPTHYGCMAKLQPPVPSN---VNFATKL 506

  Fly   292 RKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPE--- 353
             :|..|.....|..|....:...:.|:.....|           .|:.:||||.|.::.:||
  Fly   507 -QSVTQPNSDPGTVDLDTRIALIFKGKTFGNAP-----------PFLQMDSSDSETDQGKPEVFS 559

  Fly   354 ----KSDFSKNKLQLIEDELDDAIKNVLNKV--------------DFTAQLSWSKTILQAKADHL 400
                .|:.|:||.:..|       ||  |||              :...:...||..|..:.:..
  Fly   560 DVNSDSNNSENKKRSCE-------KN--NKVLHQPNEASDISSDEELIGKKDKSKLSLICEKEVN 615

  Fly   401 ERQFALADVELEK--VQTTADKMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPP-PGEIVRPPIQ 462
            :...:|:.:..::  :||.....:.::.:|...:|.:........|.|.|.:.. |.|.......
  Fly   616 DDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGIPSESASRLFS 680

  Fly   463 LGETYYAVKNKAIASW---VSIKVIEFTESTAINGNTMKSYKIRYL--------------NTPYQ 510
            .|...::...||:||:   ...|..::.:....:.|.....|::.:              :...:
  Fly   681 NGAYVHSEYLKAVASFNFDSFSKPYDYNKGALSDQNDGIRQKVKQVIGYIVEELKQILKRDVNKR 745

  Fly   511 MIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRY 575
            ||:....||   ||             .::|..| |:.:.|.:.:.|  ...:..||.
  Fly   746 MIEITAFKH---FE-------------TWWDEHT-SKARSKPLFEKA--DSTVNTPLN------- 784

  Fly   576 LIFYDDGYTQYVPHRDVRLVCQASEKVWE-------DVHAA-------------------SRDFI 614
             ...|..|.:..|  |:.|:..|..:|.:       .:.||                   .|:|:
  Fly   785 -CIKDTSYNEKNP--DINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPIPTKRNFL 846

  Fly   615 QKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSL----VLMQFEGDKNHTEWIYRGS 675
            ::   ..|....|||  |..|...:||     ..:.|...|.    |.:|....|:||..:  .|
  Fly   847 ER---DLSDQEEMVQ--RSDSDKEDSN-----VEISDTARSKIKGPVPIQESDSKSHTSGL--NS 899

  Fly   676 LRLGPV--FRETQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNA 738
            .|.|..  |..:.::..||.|:...:     ..:...:..|..|......|...::::.....|.
  Fly   900 KRKGSASSFFSSSSSSTSSEAEYEAI-----DCVEKARTSEEDSPRGYGQRNLNQRTTTIRNRNL 959

  Fly   739 LAAAS--SAATPAGG-----------RTNAGGVSTSNSAS------AVRHLNNSTIYVDDENRPK 784
            :....  :......|           ||.....|.::..:      |::..|.|||..|.|...|
  Fly   960 VGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDRTLFPALKEKNISTILSDLEEISK 1024

  Fly   785 GHVVYF-------TAKRNLP--PKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQK 840
            ...:..       |..|.:|  ||:.:  ||.           .|.:|:..|   |:....:::|
  Fly  1025 DSCIGLDENGIEPTILRKIPNTPKLNE--ECR-----------RSLTPVPPP---GYNEEEIKKK 1073

  Fly   841 T----KKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDI 901
            .    |.|..|......|........|..|.||.:..::. :|..:.:...|.|:|.::....:|
  Fly  1074 VDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMER-EFLEEQEKRIEKSLDKNLQSPNNI 1137

  Fly   902 SKGQEKMAIPLVNYYDNTLPP------PCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKC 960
            .|......    |..|.|...      .|..:..::.|..|::         ...|:|.::....
  Fly  1138 VKNNNSPR----NKNDETRKTAISQTRSCFESASKVDTTLVNI---------ISVENDINEFGPH 1189

  Fly   961 ACWQLTVAGVR--YCNPK-------KPIEEIG--------------YQYKRLHEHVPTGIYECNS 1002
            ....:...|..  |.|.|       .|:...|              :.|......|..|.|. :.
  Fly  1190 EEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDYP-SG 1253

  Fly  1003 RCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHL-LTETMANEGGQ- 1065
            :....||.|.|..: ::.:..|:.:|   |.|.      |:...|||..... |...|:|...:
  Fly  1254 KVNETKNILKREAE-NIAIVSQMTRT---GPGR------PRKDPICIQKKKRDLAPRMSNVKSKM 1308

  Fly  1066 -DAGDE---------YFADLDYIEVAEQ----------LKEGYESE------------------- 1091
             ..|||         :|...|..:..:|          |.:|.::|
  Fly  1309 TPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAEDINFIKMSYLDHLHKEPYA 1373

  Fly  1092 --------VDHSDPDA------------------------------------------------E 1100
                    |||...|.                                                .
  Fly  1374 MFLNNTHWVDHCTTDRAFWPPPSKKRRKDDELIRHKTGCARTEGFYKLDVREKAKHKYHYAKANT 1438

  Fly  1101 EDNGGPDAEDDDDFRPNYHYQR------KIKRSSRSGS----TQNSSTQSSEL------------ 1143
            ||:...|..|:.....|:|:.:      .|.|.:||..    |...|...|||
  Fly  1439 EDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQRRLLTAFGSMGESELLKFNQLKFRKKQ 1503

  Fly  1144 ------------------DSQERAVINFNPN------ADLDETVREN---SVRRLFGKDEAPYIM 1181
                              .:.:..||.:...      |||.||..|.   ....|| :.:...|:
  Fly  1504 LKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLF-RIDMETII 1567

  Fly  1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNY--EVGVVP 1244
            ||...|||.|:.||||:||.:.:.:.:::...    :..:|...|....|:|::|.:  |...:|
  Fly  1568 DATKCGNLARFINHSCNPNCYAKVITIESEKK----IVIYSKQPIGINEEITYDYKFPLEDEKIP 1628

  Fly  1245 GKVLYCQCGAPNCR 1258
                 |.|||..||
  Fly  1629 -----CLCGAQGCR 1637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	12/59 (20%)
		Pre-SET	901..1013	CDD:282838	23/140 (16%)
		SET	1022..1239	CDD:214614	67/364 (18%)
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:240750
		DUF1777	255..>380	CDD:285811	26/151 (17%)
		PRP38_assoc	<318..388	CDD:289628	15/78 (19%)
		N-SET	1341..1492	CDD:288597	21/150 (14%)
		SET	<1463..1641	CDD:225491	45/185 (24%)
		SET	1504..1625	CDD:214614	29/125 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930