DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and Kmt2a

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_038938273.1	Gene:	Kmt2a / 315606	RGDID:	1586165	Length:	3986	Species:	Rattus norvegicus

Alignment Length:	1668	Identity:	289/1668 - (17%)
Similarity:	498/1668 - (29%)	Gaps:	615/1668 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GQPTAVDCLESSGSTVE-------DVQETPASREKSYGLPVRKGENSLESPAE-QAAKDVEIEEL 59
            ||.|.|:     ||:.|       .|:.||...|........:.|:...|||. ::|...|....
  Rat  2518 GQSTQVE-----GSSKELQAPRKCSVKVTPLKMESENQSKNTQKESGPGSPAHMESACPAEPASA 2577

  Fly    60 THSEAIA-----ATGSTRKQCPYGGK------------APDEPGKLADESEDRKGENTKAIASSP 107
            :.|....     :..:|..|.|....            .||.|....|.|..|:.....|.|.|.
  Rat  2578 SRSPGAGPGVQPSPNNTSSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARSN 2642

  Fly   108 VLVAVDSDSSVELI-ESPVKFSSANESEKDPPKP-----DAVNEAAAKEAEEM-----TDSSISS 161
            :...:.....|... |..:.|.|::..:|...:.     |..::.:..:.:::     |.:.|||
  Rat  2643 MFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISS 2707

  Fly   162 PTSES------FPEKDE-----------------------KTNKENEQEPPGMEVDQDVEE-SIS 196
            ...|.      |.|:::                       .|::::.|.|.....:...|. .|.
  Rat  2708 GGDERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATSRKSSQIPKRNGKENGTENLKID 2772

  Fly   197 RPAEEYKIENTLK---GHKRISLTEIEE-HKIVDKK---DDVLEVEL-----EKGTAPKAAEDEK 249
            ||.:..:.|:.:|   |||  :..:::. |.:...|   .|.||.:|     .:........|:.
  Rat  2773 RPEDAGEKEHVIKSAVGHK--NEPKLDNCHSVSRVKAQGQDSLEAQLSSLESSRRVHTSTPSDKN 2835

  Fly   250 L------NALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMG----- 303
            |      ..|.||.|.....:|.|...:.: ..:||.|..::.......:||..:.|.:|
  Rat  2836 LLDTYNTELLKSDSDNNNSDDCGNILPSDI-MDFVLKNTPSMQALGESPESSSSELLTLGEGLGL 2899

  Fly   304 --CHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEK--SDFS------ 358
              ..:..|.|:|.::.||.|.:|:          |.....|...||:.:.|.:  ||.|
  Rat  2900 DSNREKDMGLFEVFSQQLPATEPV----------DSSVSSSISAEEQFELPLELPSDLSVLTTRS 2954

  Fly   359 -------KNKLQLIEDELDDAI----KNVLNKVDFTAQLS-----------WSKTILQA--KADH 399
                   .::|.:|.|..:..:    |:|.:.....|.||           .....:|.  .|||
  Rat  2955 PTVPSQNSSRLAVISDSGEKRVTITEKSVTSTEGDPALLSPGVDPAPEGHMTPDHFIQGHMDADH 3019

  Fly   400 LERQFALADVELEKVQTTADKMHCALYNSCPVAHKHL-PTLDIEPSDYV---HEVPPPGEIVRPP 460
            :... ....||    |...:.......:|.|.....: ||:.|:...||   .:.|.|.:|....
  Rat  3020 ISSP-PCGSVE----QGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAA 3079

  Fly   461 IQLG------------------ETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNT 507
            :|..                  :..|.:  :.:.:.|:.| |:.|...:...|.|::      ||
  Rat  3080 VQTTPPHLKPATEKLIVVNQNMQPLYVL--QTLPNGVTQK-IQLTSPVSSTPNVMET------NT 3135

  Fly   508 ---------------------PYQMIKTVTAK---------HIAYF------------------- 523
                                 |.|.:....:|         |:..|
  Rat  3136 SVLGPMGSGLTLTTGLNPSLPPSQSLFPPASKGLLSMPHHQHLHSFPAAAQSSFPPNISSPPSGL 3200

  Fly   524 ----EPPPVRLTIGTRVIAYFDGTT----------------LSRGKDKGVVQSAFYPGIIAEPLK 568
                :|||....:|:......|.||                |...|:|.:..|: .|..|| |..
  Rat  3201 LIGVQPPPDPQLLGSEANQRTDLTTTVTTPSSGLKKRPISRLHTRKNKKLAPSS-APSNIA-PSD 3263

  Fly   569 QANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRG 633
            ..:....:.|.....:.:....|:..:..:|.:...::...|:..|. |.|:..:..|  |...|
  Rat  3264 VVSNMTLINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIM-YFEQAPLLPP--QSVGG 3325

  Fly   634 QSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNH-----TEWIYRGSLRLGPVFRETQNNMNSSS 693
            .:.|...:.|                 ...|.:|     ...:..||..|..|..:|.....||:
  Rat  3326 TTATGAGSST-----------------ISQDTSHLTSGPVSALASGSSVLNVVSMQTTTTPTSST 3373

  Fly   694 A-------------------------------------QQLRVPRRTEPF--------------- 706
            :                                     |.:.:|:.:..|
  Rat  3374 SVPGHVTLANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPQSSGMFPQLGTSQTPSAAAMT 3438

  Fly   707 ---------------------IRYTKEMESSSKVNQ-----------------------QMRAFA 727
                                 .|..:|.....:|||                       |...|.
  Rat  3439 AASSICVLPSSQTAGMTAASPPREAEEQYKLQRVNQLLAGKTGTLSLQRDRDPDSAPGTQPSNFT 3503

  Fly   728 RKSSAS-----AQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHV 787
            :.:.|.     .||..|.:|..|::.:.|.:.:.|..:.:|:            |....:||..|
  Rat  3504 QTAEAPNGVRLEQNKTLPSAKQASSTSPGSSPSSGQQSGSSS------------VPGPTKPKPKV 3556

  Fly   788 VYFTAKR-NLP-----PKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVV 846
                 || .||     .|.:|......:....|.||  ..:|..:|.:....|....|:....|.
  Rat  3557 -----KRIQLPLDKGSGKKHKVSHLRTSSEAHIPHR--EANPAPQPSVKRTPRADREQQEAAGVE 3614

  Fly   847 Y--KGPCGK---SLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQE 906
            .  :..||:   ...:|.|:    :||:|..|             .:.:.:|..|::.:.|
  Rat  3615 QPSQKECGQPAGPATALPEI----QATQNPAN-------------EQENAEPKAVEEEESS---- 3658

  Fly   907 KMAIPLVNYYDNTLPPPCTYAKQRIPTEGV--HLNLDEEFLLCCDCEDDC----SDK-----SKC 960
             .:.||:.:.........:.. :|.|.:|:  .::.|:.|.:|.:..:|.    :||     |..
  Rat  3659 -FSSPLMLWLQQEQKRKESIT-ERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNA 3721

  Fly   961 ACWQLTVAGV-------------------------------RYCNPKK----PIEEIGYQYKRLH 990
            ...||:.|||                               |:..|::    |:...|.....:|
  Rat  3722 RLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH 3786

  Fly   991 --------------------EHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQ----------- 1024
                                |:.|....|...:.|..:    |.....|.|.::
  Rat  3787 LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR----RATSMDLPMPMRFRHLKKTSKEA 3847

  Fly  1025 --VFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEG 1087
              |:::...|.||.|..:|..|..:..|||:::.....     |..::|:
  Rat  3848 VGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQT-----DKREKYY--------------- 3892

  Fly  1088 YESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVIN 1152
                          |:.|...         |.::                     :|..|
  Rat  3893 --------------DSKGIGC---------YMFR---------------------IDDSE----- 3908

  Fly  1153 FNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVD--THDLRF 1215
                                       ::||...||..|:.||||.||.:.:.:.:|  .|
  Rat  3909 ---------------------------VVDATMHGNAARFINHSCEPNCYSRVINIDGQKH---- 3942

  Fly  1216 PWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
              :..|:...|..|.|||::|.:.:.....| |.|.|||..||
  Rat  3943 --IVIFAMRKIYRGEELTYDYKFPIEDASNK-LPCNCGAKKCR 3982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	13/60 (22%)
		Pre-SET	901..1013	CDD:282838	27/177 (15%)
		SET	1022..1239	CDD:214614	37/231 (16%)
Kmt2a	XP_038938273.1	zf-CXXC	1145..1192	CDD:366873
		PHD1_KMT2A	1451..1497	CDD:277063
		PHD2_KMT2A	1499..1548	CDD:277065
		PHD3_KMT2A	1586..1645	CDD:277067
		Bromo_ALL-1	1668..1798	CDD:99925
		ePHD_KMT2A	1892..2004	CDD:277163
		FYRN	2045..2092	CDD:399155
		FYRC	3686..3769	CDD:197781	14/82 (17%)
		SET_KMT2A_2B	3833..3986	CDD:380947	46/253 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930