Protein Alignment egg and Nsd1

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_001388465.1
• Gene: Nsd1 / 306764
• RGDID: 1307748
• Length: 2689
• Species: Rattus norvegicus
• Alignment Length: 1595
• Identity: 294/1595 - (18%)
• Similarity: 462/1595 - (28%)
• Gaps: 649/1595 - (40%)

  Fly    35 PVRKGENSL---------------ESPAEQAAKDVEIEELTHSEAIAATGSTRKQCPYGGKAPDE 84
            |..:.||||               ..|..::.|....|..|.:|..|.:.....:|    .:.|.
  Rat   758 PGIRNENSLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPTAAETSATSEDLSLKC----CSSDT 818

  Fly    85 PGK-LADESEDRKGENTKAI--------ASSPVLVAV-------------------DSDSSVELI 121
            .|. :...|:..|||..|.:        .||.:..||                   .|||.....
  Rat   819 NGSPMTSISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKS 883

  Fly   122 ESPVKFSSANESEKDPPKPD-----------AVNEAAAKEAEEMTDSSISS-------PTSESFP 168
            ..|:.||||:.....|.:||           .::::..||...||..:::|       ..|...|
  Rat   884 SKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNVASYRTPDRGDCSSGSP 948

  Fly   169 EKDEKT----NKENEQEPPGMEVDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKD 229
            ....|.    ...:..|.||......|..|   |...   ::.|.|....||:.:..    ||:|
  Rat   949 VGTSKVLVLGGSTHNSEKPGDSTQDSVRLS---PGGG---DSALSGELSSSLSVLPS----DKRD 1003

  Fly   230 DVLEVELEKGTAP-----KAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQYVLANM--ATLNF 287
            .....::.....|     :|....||...:|   ....|..||....|..::..|:.:  .||..
  Rat  1004 LPACGKIRSNCIPRRNCGRAKLSPKLRVTIS---TQMAKPSVNPKALKTERKRKLSRLPAVTLAA 1065

  Fly   288 YQVLRKSSKQQF---LCMGCHDTAMDLYEEYAGQLMAKQPLLLKDF---HQDHADFVALDSSDEE 346
            ..:..|.|....   |..|..|.|.:            :||...|.   .:.|.|.....|..::
  Rat  1066 NGLGNKESGGSVNGPLKGGAQDPAKE------------EPLQQMDLLRNEETHFDSKVKQSDPDK 1118

  Fly   347 EEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNK----VDFTAQLSWSKTILQAKADHLERQFALA 407
            ..||:|   .|...|...:..|:     |:.|.    ||
  Rat  1119 ILEKEP---SFENRKGPEVGSEI-----NIENDEPHGVD-------------------------- 1149

  Fly   408 DVELEKVQTTADKMHCALYNSCPVAHKHLPTL-DIEPSDYVHEVPPPGEIVRPPIQLGETYYAVK 471
                   |....|....|....|...|..... :.|.|:....|..||:    |:|.|...|..:
  Rat  1150 -------QVVPKKRWQRLNQRRPKPGKRASRFREKENSEGAFGVLLPGD----PVQKGRDDYLEQ 1203

  Fly   472 NKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRV 536
            .....|        ..|.:|.:.|                       |:::.|....||.:
  Rat  1204 RAPPTS--------ILEDSAADPN-----------------------HVSHSESVGPRLNV---- 1233

  Fly   537 IAYFDGTTLSRG---KDKGVVQSAFYPGI-----IAEPLKQANRYR------YLIFYDDGYTQ-Y 586
               .|.:::|.|   |:.|:      |.:     |.||..::.:.|      :|:.|.:.|.| :
  Rat  1234 ---CDKSSVSMGDLEKETGI------PSLTPQTKIPEPAVRSEKKRLRKPSKWLLEYTEEYDQIF 1289

  Fly   587 VPHRDVRLVCQASEKVWEDVHAASRDF--------IQKYVEKYSVDRPMVQCTRGQSMTTESNGT 643
            .|.:       ..:||.|.||..|...        .:...:...||...:..|:.:....|....
  Rat  1290 APKK-------KQKKVQEQVHKVSSRCEDESLLARCRSSAQNKQVDENSLISTKEEPPVLEREAP 1347

  Fly   644 WLYARVIDIDCSL----------------------------VLMQFEGDKNHTEWIYRGSLRLGP 680
            :|...::..|..:                            :|::..|:       |.|..:..|
  Rat  1348 FLEGPLVQSDLGVAHAELPQLTLSVPVAPEVSPRPTLESEELLVKTPGN-------YEGKRQRKP 1405

  Fly   681 VFRETQNNMNSSSAQQLRVPR-----------------------RTEPFIR-----YTKEMESSS 717
                |:..:.|:......:|:                       |..|.::     .|:..:...
  Rat  1406 ----TKKLLESNDLDPGFMPKKGDLGLSRKCCESGHLENGVGDSRATPHLKEFGGGTTRIFDKPR 1466

  Fly   718 KVNQQMRAFAR------------KSSASAQNNALAAASSAATP----AGGRTNAGGVSTSNSASA 766
            |..:|....||            :.:.|:....|....:||:|    ..|..:..|:|.|.....
  Rat  1467 KRKRQRHGTARVHYKRVKKEDSARETPSSAEGELMIHRTAASPKEILEEGIEHDPGMSASKRLQG 1531

  Fly   767 VR----HLNNSTIYVDDENRPK-GHVVYFTAK------------RNLPPKMYKCHECSPNCLFKI 814
            .|    .|..:..    :|..| |.::...|:            ..:|...:.|:||...
  Rat  1532 ERGGGAALKENVC----QNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTG----- 1587

  Fly   815 VHRLDSYSPLAKPLLSGWERLVMRQK---TKKSVVYKGP-CGKSLRSLAEVHRYLRATENVLNVD 875
            :|..                .|.:|.   .|:.::   | |||...... |.:|....     |.
  Rat  1588 IHTC----------------FVCKQSGEDVKRCLL---PLCGKFYHEEC-VQKYPPTV-----VQ 1627

  Fly   876 NFDFTPDLK-CLAEYSIDPSIVKDTDISKGQEKMAIPL-VNYYDNTLPPPCTYAKQRI------- 931
            |..|...|. |:..::.:|:   :...|||:....:.. |.|:.|..   |..|..:|
  Rat  1628 NKGFRCPLHICITCHAANPA---NVSASKGRLMRCVRCPVAYHANDF---CLAAGSKILASNSII 1686

  Fly   932 ------PTEGV----HLNLDEEF-------LLCCD-CE-------------------DDCSDKSK 959
                  |..|.    |:|:...|       ||||| |.                   :||....|
  Rat  1687 CPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKK 1751

  Fly   960 CACWQLTVAGV-RY-------CNP----------------------------------------- 975
            ....::....| ||       |:|
  Rat  1752 PHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEG 1816

  Fly   976 ----------------KKPIEEIGYQYKRL---------------------HEHV----PTG--- 996
                            ||.::|...:::.|                     ::|:    |.|
  Rat  1817 DVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQ 1881

  Fly   997 IYECN----SRCKCK----------KNCLNRVVQFSLE--------------------MKLQVFK 1027
            |:..:    .||.||          ..|:||::.:...                    ..:::|:
  Rat  1882 IFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPDVEIFR 1946

  Fly  1028 TSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEV 1092
            |..||||||...||.||.|:..|.|.|:
  Rat  1947 TLQRGWGLRTKTDIKKGEFVNEYVGELI------------------------------------- 1974

  Fly  1093 DHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNA 1157
                             |:::.|....|                        :||..:.||. ..
  Rat  1975 -----------------DEEECRARIRY------------------------AQEHDITNFY-ML 1997

  Fly  1158 DLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFS 1222
            .||             ||.   |:||...||..|:.||.|.||...|...|: .|.|   |..|:
  Rat  1998 TLD-------------KDR---IIDAGPKGNYARFMNHCCQPNCETQKWSVN-GDTR---VGLFA 2042

  Fly  1223 AAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNC 1257
            .:.|::|||||:|||.|. :..||.: |:||||||
  Rat  2043 LSDIKAGTELTFNYNLEC-LGNGKTV-CKCGAPNC 2075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	21/112 (19%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	9/81 (11%)
		HMT_MBD	823..879	CDD:238689	11/59 (19%)
		SET_SETDB1	900..1262	CDD:380915	106/530 (20%)
Nsd1	NP_001388465.1	PWWP_NSD1_rpt1	318..433	CDD:438989
		TNG2	<1452..1585	CDD:227367	23/136 (17%)
		PHD1_NSD1_2	1543..1585	CDD:277118	7/45 (16%)
		PHD2_NSD1	1590..1636	CDD:277120	12/70 (17%)
		PHD3_NSD1	1637..1690	CDD:277123	11/58 (19%)
		PHD4_NSD1	1707..1746	CDD:277126	7/38 (18%)
		PWWP_NSD1_rpt2	1753..1848	CDD:438992	9/94 (10%)
		AWS	1899..1937	CDD:465559	3/37 (8%)
		SET_NSD1	1939..2080	CDD:380987	63/238 (26%)
		PHD5_NSD1	2118..2160	CDD:277129
		C5HCH	2159..2208	CDD:465605
		PHA03247	<2221..2593	CDD:223021