Protein Alignment egg and Ezh1

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_001100521.1
• Gene: Ezh1 / 303547
• RGDID: 1305028
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 129/674 - (19%)
• Similarity: 216/674 - (32%)
• Gaps: 243/674 - (36%)

  Fly   612 DFIQKYVEKYSVDRPMV---QCT------------RGQSMTTESNGTWLYARVIDIDCSLVLMQF 661
            |..::|.|...:..|..   |||            |.||:  .|..|....|....||  .|..|
  Rat   252 DMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSL--HSFHTLFCRRCFKYDC--FLHPF 312

  Fly   662 EGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRV---PRRTEPFIRYTKEMESSSKVNQQM 723
            ....|    :|:...|                  ::::   |...:.|:......|.:...|.:.
  Rat   313 HATPN----VYKRKNR------------------EIKIEPEPCGADCFLWLEGAKEYAMLHNPRS 355

  Fly   724 RAFARKS------SASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENR 782
            :...|:.      |||..|.  :|::.|.|..|......|...::|:|..    ||......:.:
  Rat   356 KCSGRRRRRHPVVSASCSNT--SASAMAETKEGDSDRDTGNDWASSSSEA----NSRCQTPTKQK 414

  Fly   783 PKGHVVYFTAKRNLPPKMYKCHECSPN----------CLFKIVH--RLDSYSPLAKPLLSGWERL 835
            ..          ..||::  |...:|:          .||::.|  ..:::..:|:.|.:...:.
  Rat   415 AS----------PAPPQL--CVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQ 467

  Fly   836 VMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTD 900
            |.:...|:|::.|.|                 |:.::|       |..|...::.:..:..:...
  Rat   468 VFQFAVKESLILKLP-----------------TDELMN-------PSQKKKRKHRLWAAHCRKIQ 508

  Fly   901 ISKGQEKMAIPLVNYYDNTLPP-PCTYAKQRIPTEGVHLNLDEEFLLC----------CDCEDDC 954
            :.|  :..:..:.||.....|. ||......|.|:    |..|:|..|          |.|:..|
  Rat   509 LKK--DNNSTQVYNYQPCDHPDRPCDSTCPCIMTQ----NFCEKFCQCSPDCQNRFPGCRCKTQC 567

  Fly   955 SDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSL 1019
            :.| :|.|:    ..||.|:|...: ..|     ..||....:..|       |||   .:|..|
  Rat   568 NTK-QCPCY----LAVRECDPDLCL-TCG-----ASEHWDCKVVSC-------KNC---SIQRGL 611

  Fly  1020 EMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQL 1084
            :..|.:..:...|||......:.|..||..|.|.|:::..|:..|: ..|:|
  Rat   612 KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGK-VYDKY------------- 662

  Fly  1085 KEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERA 1149
                                                                  .||.|
  Rat   663 ------------------------------------------------------MSSFL------ 667

  Fly  1150 VINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLR 1214
               ||.|.|                    :::||...||..|:.|||.:||.:.:.|.|: .|.|
  Rat   668 ---FNLNND--------------------FVVDATRKGNKIRFANHSVNPNCYAKVVMVN-GDHR 708

  Fly  1215 FPWVAFFSAAHIRSGTELTWNYNY 1238
               :..|:...|::|.||.::|.|
  Rat   709 ---IGIFAKRAIQAGEELFFDYRY 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	3/9 (33%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	15/65 (23%)
		HMT_MBD	823..879	CDD:238689	9/55 (16%)
		SET_SETDB1	900..1262	CDD:380915	73/350 (21%)
Ezh1	NP_001100521.1	EZH2_WD-Binding	39..68	CDD:463308
		PRC2_HTH_1	159..262	CDD:436286	3/9 (33%)
		SANT	433..474	CDD:238096	6/40 (15%)
		preSET_CXC	560..591	CDD:408079	11/41 (27%)
		SET_EZH1	608..743	CDD:380994	44/223 (20%)