Protein Alignment egg and SETBP1

DIOPT Version :9

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_024306917.1
• Gene: SETBP1 / 26040
• HGNCID: 15573
• Length: 1622
• Species: Homo sapiens
• Alignment Length: 1219
• Identity: 231/1219 - (18%)
• Similarity: 404/1219 - (33%)
• Gaps: 411/1219 - (33%)

  Fly    22 QETPASREKSYG----LPVRKGENSLESPAEQAAKDVEIEELTHSEAIAATGSTRKQCPYGGKAP 82
            :||.:|..:..|    |||    :|.:.||.....         .|.:.:|....|..|.||:
Human     4 RETLSSSRQRGGESDFLPV----SSAKPPAAPGCA---------GEPLLSTPGPGKGIPVGGE-- 53

  Fly    83 DEPGKLADESEDRKGENTKAIASSPVLVAVDSDSSVELIESPVKFSSANESEKDPPKPDAVNEAA 147
                ::..|.||..|....          |||:|:.:    ..|:.:.:..|:        .|.:
Human    54 ----RMEPEEEDELGSGRD----------VDSNSNAD----SEKWVAGDGLEE--------QEFS 92

  Fly   148 AKEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGME--VDQDVEESISRPAEEYKI----EN 206
            .||| ..|:.|:......:...|....|.||...||.::  :.|..::.:||..:..|.    |.
Human    93 IKEA-NFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSGDQKVSRAGKNSKATKEEER 156

  Fly   207 TLKGHKRISLTEIE-----EHKIVDKKD---------DVLEVELEKGTAPKAAE-DEKLNALLSD 256
            :....|.:::|..:     .|..|..:|         |:...:| ||..|:|.| .:|.:.|..|
Human   157 SHSKKKGVTVTYSDLPSCVWHSAVIAEDCLGILLTASDLAASDL-KGFQPQAYERPQKHSTLHYD 220

  Fly   257 --------GDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFL-----------CM 302
                    ||....|          |:|                |||.|..:           ..
Human   221 TGLPQDFTGDTLKPK----------HQQ----------------KSSSQNHMDWSTNSDSGPVTQ 259

  Fly   303 GC-------HDTAMDLYEEYAGQLMAKQPL---------------LLKDFHQDHADFV--ALDSS 343
            .|       .:||.      ..::.|.:|:               .......::.|.:  .:..|
Human   260 NCFISPESGRETAS------TSKIPALEPVASFAKAQGKKGSAGNTWSQLSNNNKDLLLGGVAPS 318

  Fly   344 DEEEEEKQPEKSDFSKNKLQLIEDE-----------------LDDAIKNVLNKVDFTAQLSWSKT 391
            ........|..|....|.||.:.|:                 ...:.|:|:::......|.|.|.
Human   319 PSSHSSPAPPSSSAECNGLQPLVDQDGGGTKEPPEPPTVGSKKKSSKKDVISQTIPNPDLDWVKN 383

  Fly   392 ILQAKADHLE--RQFALADVELE------KVQTTA----DKMHCALYNSCPVAHKHLPTLDIEPS 444
             .|...|:.|  |:...||...|      .|.:.:    |..|..:  :.|:   ..|:||  |:
Human   384 -AQKAFDNTEGKREGYSADSAQEASPARQNVSSASNPENDSSHVRI--TIPI---KAPSLD--PT 440

  Fly   445 DYVHE----VPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAIN-------GNTMK 498
            ::..:    :....|.:.|            .||:||.:::      .|..:|       || .|
Human   441 NHKRKKRQSIKAVVEKIMP------------EKALASGITM------SSEVVNRILSNSEGN-KK 486

  Fly   499 SYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGII 563
            ..::..|:   :||:.         |.|.|.|..|              |..:.|:     ||.:
Human   487 DPRVPKLS---KMIEN---------ESPSVGLETG--------------GNAEKVI-----PGGV 520

  Fly   564 AEPLKQANRYRYLIFYDDGYTQYVPHR---DVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDR 625
            ::|.|..     ::......|.:.|.|   :::....|:::.|..........:::.|...| |:
Human   521 SKPRKPP-----MVMTPPTCTDHSPSRKLPEIQHPKFAAKRRWTCSKPKPSTMLREAVMATS-DK 579

  Fly   626 PMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNH--------TEWIYRGSLR--LGP 680
            .|::......:|..|.   ||.   :.|...|:...:..:..        .|.|:.|:..  :.|
Human   580 LMLEPPSAYPITPSSP---LYT---NTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSP 638

  Fly   681 VFRE------TQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQ-------------QMRAF 726
            :.||      .:...|.:...|| ||...:|.    .||:...||.:             :|:..
Human   639 ISREFPGTKKRKRRRNLAKLAQL-VPGEDKPM----SEMKFHKKVGKLGVLDKKTIKTINKMKTL 698

  Fly   727 ARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAV-----RHLNNS---TIYVDDENRP 783
            .||   :..|..|:.:||.|..|     .....||..|:|:     :.:|.|   |||:..:...
Human   699 KRK---NILNQILSCSSSVALKA-----KAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGR 755

  Fly   784 KGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVH-RLDSYSPLAKPLLSGWERLVMRQKTKKSVVY 847
            |       .:..|||...:     |....|  | |..|..|....:.|.::.||
Human   756 K-------PRAELPPPSEE-----PKTAIK--HPRPVSSQPDVPAVPSNFQSLV----------- 795

  Fly   848 KGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTP--------DLKCLAEYSIDPSIVKDTDISKG 904
                   ..|.|.:|    .....|...|.:.:|        :||.:.  ::.|.....|...||
Human   796 -------ASSPAAMH----PLSTQLGGSNGNLSPASTETNFSELKTMP--NLQPISALPTKTQKG 847

  Fly   905 QE----KMAIP------------LVNYYDNTLPPPC-TYAKQRIPTE-GVHLNLDEEFLLCCDCE 951
            ..    |::.|            :.:..:.||.|.. :::::.||:: |:..:           .
Human   848 IHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTD-----------N 901

  Fly   952 DDCSDKSKCACWQLTVAGVRYCNPKKPIEEI----------GYQYKRL-------HEHVPTGIYE 999
            :..||:::.:..........:|:...| |.|          |::.|.|       ||.:....::
Human   902 NSTSDQAEKSSESRRRYSFDFCSLDNP-EAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHK 965

  Fly  1000 CNSRCKCKKNCLNR-VVQFSLEM-----KLQVFKTSNRGWGLRCVNDIP 1042
                 :.:|:..|| .:||..::     |.|||:.|:|.:.....|..|
Human   966 -----RKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYP 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	9/55 (16%)
		Pre-SET	901..1013	CDD:282838	22/146 (15%)
		SET	1022..1239	CDD:214614	8/21 (38%)
SETBP1	XP_024306917.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930