DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment egg and Setbp1

DIOPT Version :10

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:NP_444329.2 Gene:Setbp1 / 240427 MGIID:1933199 Length:1582 Species:Mus musculus


Alignment Length:1388 Identity:244/1388 - (17%)
Similarity:416/1388 - (29%) Gaps:527/1388 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKDVEIEELTHSE------AIAATGS 70
            :..|.:.:|:.|.|                :|.|..:.:.||:..:.|.:|:      |..|..:
Mouse   309 DQDGGSTKDLPEPP----------------TLSSKKKSSKKDMISQTLPNSDLDWVKSAQKAFET 357

  Fly    71 TRKQCPYGGKAPDEPGKLADESEDRKGENTKAIASSPVLVAVDSDSSVELIESPVKFSSANESEK 135
            |.             ||....|.|...|.:.|..|...:...::|||...|..|:|..|.:.|..
Mouse   358 TE-------------GKREAYSADSAQEASPARQSISSVSNPENDSSHVRITIPIKTPSLDPSNH 409

  Fly   136 DPPKPDAVNEAAAKEAEEMTDSSISSPTSE---------SFPEKDEKTNK-----ENEQEPPGME 186
            ...|..::.....|...|...:|..|.:||         ...:||.:..|     |||....|:|
Mouse   410 KRKKRQSIKAVVEKIVPEKALASGISMSSEVVNRILSNSEGSKKDPRVPKLGKMIENETPSVGLE 474

  Fly   187 VDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKDDVLEVELEKGTAPKAAEDEKLN 251
            ...:.|:.:...|.:.:     |....::.....||....|   :.|::..|..|.:.....|..
Mouse   475 TGGNAEKIVPGGASKQR-----KPPMVMTSPTRTEHAPSGK---LSEIQHPKFAAKRRCSKAKPP 531

  Fly   252 ALLSDGDVFYDKECVNCNCTKLHKQ----Y-------VLANMATLNFYQVLRKS----SKQQFLC 301
            |:|        :|.|.....||..:    |       :..|..:|.....::|.    .||..| 
Mouse   532 AML--------REAVLATAEKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLL- 587

  Fly   302 MGCHDTAMDLYE------------EYAGQLMAK----------------QPLLLKDFHQDHADFV 338
                 |...::|            |:.|....|                :|:....||:......
Mouse   588 -----TVETIHEGTSTSPVSPISREFPGTKKRKRRRNLAKLAQLVPGEDKPMSEMKFHKKVGKLG 647

  Fly   339 ALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTI-LQAKADHLER 402
            .||           :|:..:.||::.::.      ||:||::     ||.|.:: |:|||.. |.
Mouse   648 VLD-----------KKTIKTINKMKTLKR------KNILNQI-----LSCSSSVALKAKAPP-ET 689

  Fly   403 QFALADVELE-------------------------KVQTTADKMHCALYNSCPVAHKHLPTLDIE 442
            ....|.:|.:                         ::...:::...|:.:..||:.:  |.:...
Mouse   690 SPGAASIESKLGKQINVSKRGTIYIGKKRGRKPRTELPPPSEEPKTAIKHPRPVSSQ--PDVPAV 752

  Fly   443 PSDYVHEVPPPGEIVRP-PIQLG-----------ETYYAVKNKAIASWVSIKVIEFTESTAINGN 495
            ||.:...|......:.| ..|||           ||.:: :.|.:.:...|..:.......|:|.
Mouse   753 PSSFQSPVASSPAAMHPLSTQLGGSNGNLSPASTETNFS-ELKTMPNLQPISALPTKTQKGIHGG 816

  Fly   496 TMKSYKIRYL-NTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFY 559
            |.|....|.: |:|..:.:..:.|.|                       |||             
Mouse   817 TWKLSPPRLMANSPSHLCEIGSLKEI-----------------------TLS------------- 845

  Fly   560 PGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVD 624
                  |:.:::. ...|..|.|.     ..|.......:||..|.....|.||.       |:|
Mouse   846 ------PVSESHS-EETIPSDSGI-----GTDNNSTSDQAEKSSESRRRYSFDFC-------SLD 891

  Fly   625 RPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNM 689
            .|  :.....:.|...:|......::|                 .::...||:.....|:.::..
Mouse   892 NP--EAIPSDTSTKNRHGHRQKHLIVD-----------------TFLAHESLKKPKHKRKRKSLQ 937

  Fly   690 NSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTN 754
            |....|             :..|:|.                                       
Mouse   938 NRDDLQ-------------FLAELEE--------------------------------------- 950

  Fly   755 AGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLD 819
               :.|......:.|              :|:..|              ||.....:|:|  ..|
Mouse   951 ---LITKFQVFRISH--------------RGYTFY--------------HENPYPSIFRI--NFD 982

  Fly   820 SYSPLA----KPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDF- 879
            .|.|:.    .|||  :.|.....|:||.   :|...|:..::.:| .:|:         .|.: 
Mouse   983 QYYPVPYIQYDPLL--YLRRTSDLKSKKK---RGRPAKTNDTMTKV-PFLQ---------GFSYP 1032

  Fly   880 TPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVN--YYDN--------------------TLPP 922
            .|.....|.|              |....::|::|  ||..                    |:||
Mouse  1033 IPSGSYYAPY--------------GMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRPTVPP 1083

  Fly   923 PCTYAKQRI---------PTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVA-GVRYCNPKK 977
            |..:|...:         ...||||                         |.||. |:....|..
Mouse  1084 PQFHASSHVKISGATKHKAKHGVHL-------------------------QGTVGMGLGDIQPSL 1123

  Fly   978 PIEEIG-------YQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGL 1035
            ...::|       ..:||.|:|.             :|:..:|::.                   
Mouse  1124 NPPKVGGATLSSSRLHKRKHKHK-------------RKHKEDRILG------------------- 1156

  Fly  1036 RCVNDIPKGAF---ICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDP 1097
              .:|...|.|   ...::.|||:|.::   |.|      .:|..:....:.||..:.:...:..
Mouse  1157 --THDNLSGLFAGKATGFSSHLLSERLS---GSD------KELPLVSEKSKHKERQKHQHGEASH 1210

  Fly  1098 DAEEDNGGPD---------------AEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQE 1147
            ...::|...|               |:|..|. .:...:...||.|.||   ..||:|..||   
Mouse  1211 KVSKNNFEVDTLSTLSLSDAQHWTQAKDKGDL-SSEPVESCAKRYSGSG---GDSTRSEGLD--- 1268

  Fly  1148 RAVINFNPNADLDETVRENSVRRLF-------GKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQN 1205
             .....||::|..::....|.||.|       .||...:.|:.|..|:    :..|.||.:...:
Mouse  1269 -VFSEMNPSSDKWDSDMGGSKRRSFEGFGTYREKDIQAFKMNRKERGS----YESSMSPGMPSPH 1328

  Fly  1206 VFVDTHDLRFPWVAFFSAAHIRS 1228
            :.||.           :|||.:|
Mouse  1329 LKVDQ-----------TAAHSKS 1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 Tudor_SETDB1_rpt1 532..622 CDD:410453 14/89 (16%)
Tudor_SETDB1_rpt2 630..684 CDD:410548 5/53 (9%)
HMT_MBD 823..879 CDD:238689 13/59 (22%)
SET_SETDB1 900..1262 CDD:380915 74/393 (19%)
Setbp1NP_444329.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..246
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..416 29/135 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..513 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..787 11/79 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..880 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1155 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1215 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1265 10/32 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1429..1461
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1470..1489
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1582
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.