Protein Alignment egg and Setdb2

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_001307649.1
• Gene: Setdb2 / 239122
• MGIID: 2685139
• Length: 697
• Species: Mus musculus
• Alignment Length: 762
• Identity: 225/762 - (29%)
• Similarity: 318/762 - (41%)
• Gaps: 205/762 - (26%)

  Fly   639 ESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRT 703
            |.||          |.....|:.:.|         |.:.|  :|.:|||.::|.. |:::....|
Mouse     3 EKNG----------DAKTFWMELQDD---------GKVDL--MFEKTQNVLHSLK-QKIKDGSAT 45

  Fly   704 EPFIRYTKEM----ESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSA 764
            ..  .|.:.|    |::....|.:.......:.|.|.|     .|:|.|              ||
Mouse    46 NG--DYVQAMNLVNEATLSNTQTLEKDHTPVTQSEQEN-----KSSAVP--------------SA 89

  Fly   765 SAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKC----------------HECSPNCLFK 813
            |.            |.:.|||..:....|:...|...|.                |.||..||.:
Mouse    90 SC------------DNSCPKGCTIPSPGKKVFLPVKNKADNLVKKEAPLHISFHRHICSRTCLME 142

  Fly   814 IVHRLDSYSPLAKPLLSGWERLVMRQKTKKS---VVYKGPCGKSLRSLAEVHRYLRATE-NVLNV 874
            ....|...:||..|:...::|...:..:..|   |.||.|||::||::.||..||..|| |.|..
Mouse   143 TPLSLKGENPLQLPIRCHFQRRHAKTNSHSSALHVNYKTPCGRNLRNMEEVFHYLLETECNFLFT 207

  Fly   875 DNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLN 939
            |||.|...::....:.....:|.|.|||.|.|.::||..|..||:..|...| :..:.....|||
Mouse   208 DNFSFNTYVQLTRNHPKQNEVVSDVDISNGVESVSIPFCNEIDNSKLPRFKY-RNTVWPRIYHLN 271

  Fly   940 LDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRC 1004
            ....|...|||.:.|.|..||||.|||....:.|......|..||:||||...:||||||||..|
Mouse   272 FSNMFSDSCDCSEGCIDIKKCACLQLTAKNAKACPLSSDGECAGYKYKRLQRLIPTGIYECNLLC 336

  Fly  1005 KCKKN-CLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLL-----TETMANEG 1063
            ||.|. |.|||:|..:.::|||||:..:|||:||::||.||.|:|||:|.||     .:|...|.
Mouse   337 KCNKQMCQNRVIQHGVRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLRRATPEKTNIGEN 401

  Fly  1064 GQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAED-----DDDFRPN------ 1117
            |::.        .:| |.....:..:.||..||.||..|:  |.|||     ..|.:..
Mouse   402 GREQ--------QHI-VKNSFSKKRKLEVVCSDCDAHCDS--PKAEDCPPKLSGDLKEPAVEMNH 455

  Fly  1118 ---------------------YHYQRK----IKRSSRSGSTQNSSTQSSE-LDSQERAV---INF 1153
                                 :||..|    :...|.:...:|....:.| ::|:.|..   ::.
Mouse   456 RNISRTQHHSVIRRTKSKTTVFHYSEKNMGFVCSDSAAPEDKNGFKPAQEHVNSEARRAHEDLSS 520

  Fly  1154 NPNADLDET------------VRENS-------------------VRRLFGK------------- 1174
            ||..|.::|            .||:|                   |..:.||
Mouse   521 NPAGDSEDTQLTESDVIDITASREDSAPAYRCKHATIVDRKDTKQVLEVPGKKSQEEEPAASQSQ 585

  Fly  1175 -----DEAP-------------------YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRF 1215
                 :|.|                   :::||...||:||:.||||.|||:||||||:|||..|
Mouse   586 QALCDEELPSERTKIPSASLMQLSKESLFLLDASKEGNVGRFLNHSCCPNLWVQNVFVETHDRNF 650

  Fly  1216 PWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL 1262
            |.||||:..::::.|||||:|.||.|..|.|.:.||||...||.:|:
Mouse   651 PLVAFFTNRYVKARTELTWDYGYEAGATPAKEILCQCGFNKCRKKLI 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453
		Tudor_SETDB1_rpt2	630..684	CDD:410548	9/44 (20%)
		HMT_MBD	823..879	CDD:238689	24/59 (41%)
		SET_SETDB1	900..1262	CDD:380915	156/475 (33%)
Setdb2	NP_001307649.1	HMT_MBD	152..212	CDD:238689	24/59 (41%)
		SET	210..696	CDD:394802	160/497 (32%)
		SET	365..>435	CDD:459965	29/80 (36%)