DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and Setd1a

DIOPT Version :9

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:NP_821172.2 Gene:Setd1a / 233904 MGIID:2446244 Length:1716 Species:Mus musculus


Alignment Length:1431 Identity:240/1431 - (16%)
Similarity:415/1431 - (29%) Gaps:611/1431 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TAVDCLESSGSTVEDVQETPASREKSYGLPVR--------KGENSLES---PAEQAAKDVEIEEL 59
            ||.......|:..|.....|..:|.:||||..        :|..|.|:   |...||:.:....:
Mouse   715 TAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGSYSREAYHLPLPMAAEPLPSSSV 779

  Fly    60 THSEAIAATGSTRKQCPYGGKAPDEPGKLADESEDRKGENTKAIASSPVLVA------------- 111
            :..||         :.|:           .:|:|         ||.|.||.:             
Mouse   780 SGEEA---------RLPH-----------REEAE---------IAESKVLPSAGTVGRVLATLVQ 815

  Fly   112 -----VDSDSSVELIESPVKFSSAN---ESEKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFP 168
                 :..|.:.:::|: |.|.:.:   ||:::..||  ...||.::|:|              .
Mouse   816 EMKSIMQRDLNRKMVEN-VAFGAFDQWWESKEEKAKP--FQNAAKQQAKE--------------E 863

  Fly   169 EKDEKTNKENEQEPPGM--EVDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKDDV 231
            :|::...||     |||  .||......|: ..|.:...:.|:|..|:...:::.    .:..::
Mouse   864 DKEKMKLKE-----PGMLSLVDWAKSGGIT-GIEAFAFGSGLRGALRLPSFKVKR----KEPSEI 918

  Fly   232 LEVELEKGTAPK--AAEDEKLNALLSDGDVFYDKECVNCN--CTKLHKQYVLANMATLNFYQVLR 292
            .|...||...|.  |.|||        .|...:||.....  .||..|:                
Mouse   919 SEASEEKRPRPSTPAEEDE--------DDPEREKEAGEPGRPGTKPPKR---------------- 959

  Fly   293 KSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDF 357
              .:::....|.|..:..|..|  |:..:::....||  :|       |..::||:|:|.|..|.
Mouse   960 --DEERGKTQGKHRKSFTLDSE--GEEASQESSSEKD--ED-------DDDEDEEDEEQEEAVDA 1011

  Fly   358 SKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTADKMH 422
            :|.:.:..:.|.:|:        |.::|.|     |.|.:|  ....:.:|.|.....:::....
Mouse  1012 TKKEAEASDGEDEDS--------DSSSQCS-----LYADSD--GENGSTSDSESGSSSSSSSSSS 1061

  Fly   423 CALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRP---PIQLGETYYAVKNKAIASWVSIKVI 484
            .:..:|...:...    :.|.|..:....||.|:..|   |.:..||         ...|...|:
Mouse  1062 SSSSSSSSESSSE----EEEQSAVIPSASPPREVPEPLPAPDEKPET---------DGLVDSPVM 1113

  Fly   485 EFTESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGK 549
            ..:|...:               |.|......       ||||                      
Mouse  1114 PLSEKETL---------------PTQPAGPAE-------EPPP---------------------- 1134

  Fly   550 DKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFI 614
                    ..|...|||                                        .|...|..
Mouse  1135 --------SVPQPPAEP----------------------------------------PAGPPDAA 1151

  Fly   615 QKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLG 679
            .:..|:.|...|::                                                   
Mouse  1152 PRLDERPSSPIPLL--------------------------------------------------- 1165

  Fly   680 PVFRETQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASS 744
            |..::.:..::.|:|::..||   ||                                      |
Mouse  1166 PPPKKRRKTVSFSAAEEAPVP---EP--------------------------------------S 1189

  Fly   745 AATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPN 809
            .|.|...: ::|.||                      |....||..|. ||||            
Mouse  1190 TAAPLQAK-SSGPVS----------------------RKVPRVVERTI-RNLP------------ 1218

  Fly   810 CLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNV 874
                    ||..|     |:..|...|.|....::       |..:||..|.    .|||:...|
Mouse  1219 --------LDHAS-----LVKSWPEEVARGGRNRA-------GGRVRSTEEE----EATESGTEV 1259

  Fly   875 DNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAI----------PLV-------NYYDNTLPP 922
                   ||..||:.::.|:......:..|.:..|.          ||:       ||.....||
Mouse  1260 -------DLAVLADLALTPARRGLATLPTGDDSEATETSDEAERPSPLLSHILLEHNYALAIKPP 1317

  Fly   923 PCTYA-----------------------------------KQRIPTEGVHLNLDEEFLLCCDCED 952
            |.|.|                                   ||::..:......:||       |:
Mouse  1318 PTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEPKQQLQQQHPEQEGEEE-------EE 1375

  Fly   953 DCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHV------------PTGIYECNSRCK 1005
            |..::|:.:         ...:.....||...:.:.|..|.            |...:|..|   
Mouse  1376 DEEEESESS---------ESSSSSSSDEEGAIRRRSLRSHTRRRRPPLPPPPPPPPSFEPRS--- 1428

  Fly  1006 CKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDE 1070
                        ..|....::...|.|.      |:...:::.:....||.:|        :|.:
Mouse  1429 ------------EFEQMTILYDIWNSGL------DLEDMSYLRLTYERLLQQT--------SGAD 1467

  Fly  1071 YFADLDYIE-------VAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSS 1128
            :..|..:::       ..::.:...:...:|....|..:...|.::.:.|     .|......|:
Mouse  1468 WLNDTHWVQHTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKD-----KYLDVCPVSA 1527

  Fly  1129 R---SGSTQNSSTQSSELDSQERAVIN-FNPNADLDETV--------RENSVRRLFGKD------ 1175
            |   .|.||.::...||..|::|.::: ...:|.:|..:        |:..:|  ||:.      
Mouse  1528 RQLEGGDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLR--FGRSRIHEWG 1590

  Fly  1176 -----------------------------EAPY-----------------IMDAKTTGNLGRYFN 1194
                                         |..|                 |:||...|||.|:.|
Mouse  1591 LFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFIN 1655

  Fly  1195 HSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNY--EVGVVPGKVLYCQCGAPNC 1257
            |.|:||.:.:.:.:::...    :..:|...|....|:|::|.:  |...:|     |.||..:|
Mouse  1656 HCCTPNCYAKVITIESQKK----IVIYSKQPIGVDEEITYDYKFPLEDNKIP-----CLCGTESC 1711

  Fly  1258 R 1258
            |
Mouse  1712 R 1712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 HMT_MBD 823..879 CDD:238689 12/55 (22%)
Pre-SET 901..1013 CDD:282838 25/175 (14%)
SET 1022..1239 CDD:214614 47/289 (16%)
Setd1aNP_821172.2 RRM_Set1A 92..186 CDD:240992
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..367
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 516..670
Topoisomer_IB_N <835..>883 CDD:322080 17/68 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 849..869 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..1206 82/570 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1230..1259 9/39 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1275..1297 2/21 (10%)
HCFC1-binding motif (HBM). /evidence=ECO:0000250|UniProtKB:O15047 1307..1311 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1355..1427 13/87 (15%)
Interaction with CFP1. /evidence=ECO:0000250|UniProtKB:O15047 1424..1459 6/55 (11%)
N-SET 1434..1571 CDD:314603 24/155 (15%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250|UniProtKB:O15047 1459..1546 17/99 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1508 2/27 (7%)
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:O15047 1501..1506 1/4 (25%)
SET 1577..1700 CDD:214614 23/128 (18%)
PostSET 1700..1716 CDD:214703 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848365
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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