DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and EZH1

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001308008.1	Gene:	EZH1 / 2145	HGNCID:	3526	Length:	753	Species:	Homo sapiens

Alignment Length:	676	Identity:	132/676 - (19%)
Similarity:	219/676 - (32%)	Gaps:	247/676 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 DFIQKYVEKYSVDRPMV---QCT------------RGQSMTTESNGTWLYARVIDIDCSLVLMQF 661
            |..::|.|...:..|..   |||            |.||:  .|..|....|....||.|
Human   258 DMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSL--HSFHTLFCRRCFKYDCFL----- 315

  Fly   662 EGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRV---PRRTEPFIRYTKEMESSSKVNQQM 723
                 |.             |..|. |:.....:::::   |..|:.|:......|.:...|.:.
Human   316 -----HP-------------FHATP-NVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRS 361

  Fly   724 RAFARKS------SASAQNNALAAASSAATPAGGRT--NAGGVSTSNSASAVRHLNNSTIYVDDE 780
            :...|:.      |||..|   |:||:.|....|.:  :.|....|:|:.|     ||......:
Human   362 KCSGRRRRRHHIVSASCSN---ASASAVAETKEGDSDRDTGNDWASSSSEA-----NSRCQTPTK 418

  Fly   781 NRPKGHVVYFTAKRNLPPKMYKCHECSPN----------CLFKIVH--RLDSYSPLAKPLLSGWE 833
            .:..          ..||::  |...:|:          .||::.|  ..:::..:|:.|.:...
Human   419 QKAS----------PAPPQL--CVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTC 471

  Fly   834 RLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKD 898
            :.|.:...|:|::.|.|                 |:.::|       |..|...::.:..:..:.
Human   472 KQVFQFAVKESLILKLP-----------------TDELMN-------PSQKKKRKHRLWAAHCRK 512

  Fly   899 TDISKGQEKMAIPLVNYYDNTLPP-PCTYAKQRIPTEGVHLNLDEEFLLC----------CDCED 952
            ..:.|  :..:..:.||.....|. ||......|.|:    |..|:|..|          |.|:.
Human   513 IQLKK--DNSSTQVYNYQPCDHPDRPCDSTCPCIMTQ----NFCEKFCQCNPDCQNRFPGCRCKT 571

  Fly   953 DCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQF 1017
            .|:.| :|.|:    ..||.|:|...: ..|     ..||....:..|       |||   .:|.
Human   572 QCNTK-QCPCY----LAVRECDPDLCL-TCG-----ASEHWDCKVVSC-------KNC---SIQR 615

  Fly  1018 SLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAE 1082
            .|:..|.:..:...|||......:.|..||..|.|.|:::..|:..|: ..|:|
Human   616 GLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGK-VYDKY----------- 668

  Fly  1083 QLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQE 1147
                                                                    .||.|
Human   669 --------------------------------------------------------MSSFL---- 673

  Fly  1148 RAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHD 1212
                 ||.|.|                    :::||...||..|:.|||.:||.:.:.|.|: .|
Human   674 -----FNLNND--------------------FVVDATRKGNKIRFANHSVNPNCYAKVVMVN-GD 712

  Fly  1213 LRFPWVAFFSAAHIRSGTELTWNYNY 1238
            .|   :..|:...|::|.||.::|.|
Human   713 HR---IGIFAKRAIQAGEELFFDYRY 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	9/55 (16%)
		Pre-SET	901..1013	CDD:282838	29/122 (24%)
		SET	1022..1239	CDD:214614	42/217 (19%)
EZH1	NP_001308008.1	EZH2_WD-Binding	45..73	CDD:288468
		SANT	439..480	CDD:238096	6/40 (15%)
		SANT	439..480	CDD:197842	6/40 (15%)
		SET	<469..733	CDD:225491	80/415 (19%)
		SET	619..740	CDD:214614	42/218 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930