DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and Kmt2a

DIOPT Version :10

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:NP_001344478.1 Gene:Kmt2a / 214162 MGIID:96995 Length:3966 Species:Mus musculus


Alignment Length:1661 Identity:292/1661 - (17%)
Similarity:508/1661 - (30%) Gaps:601/1661 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GQPTAVDCLESSGSTVE-------DVQETPASREKSYGLPVRKGENSLESPAEQA--AKDVEIEE 58
            ||.|.|:     ||:.|       .|:.||...|         |||..::..:::  .....||.
Mouse  2498 GQSTQVE-----GSSKELQAPRKCSVKVTPLKME---------GENQSKNTQKESGPGSPAHIES 2548

  Fly    59 LTHSEAIAATGS-------------TRKQCPYGGK------------APDEPGKLADESEDRKGE 98
            :..:|.::|:.|             |..|.|....            .||.|....|.|..|:..
Mouse  2549 VCPAEPVSASRSPGAGPGVQPSPNNTLSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYP 2613

  Fly    99 NTKAIASSPVLVAVDSDSSVELI-ESPVKFSSANESEKDPPKP-----DAVNEAAAKEAEEM--- 154
            ...|.|.|.:...:.....|... |..:.|.|.:..:|...:.     |..::.:..:.:::   
Mouse  2614 RRSARARSNMFFGLTPLYGVRSYGEEDIPFYSNSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYY 2678

  Fly   155 --TDSSISSPTSES------FPEKDE-----------------------KTNKENEQEPPGMEVD 188
              |.:.|||...|.      |.|:::                       .|::::.|.|.....:
Mouse  2679 NFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATSRKSSQIPKRNGKE 2743

  Fly   189 QDVEE-SISRPAEEYKIENTLK---GHKRISLTEIEE-HKIVDKK---DDVLEVEL-----EKGT 240
            ...|. .|.||.:..:.|:.:|   |||  :..:::. |.:...|   .|.||.:|     .:..
Mouse  2744 NGTENLKIDRPEDAGEKEHVIKSAVGHK--NEPKLDNCHSVSRVKAQGQDSLEAQLSSLESSRRV 2806

  Fly   241 APKAAEDEKL----NA--LLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQF 299
            ......|:.|    ||  |.||.|.....:|.|...:.: ..:||.|..::.......:||..:.
Mouse  2807 HTSTPSDKNLLDTYNAELLKSDSDNNNSDDCGNILPSDI-MDFVLKNTPSMQALGESPESSSSEL 2870

  Fly   300 LCMG-------CHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEK--S 355
            |.:|       ..:..:.|:|.::.||.|.:|:          |.....|...||:.:.|.:  |
Mouse  2871 LTLGEGLGLDSNREKDIGLFEVFSQQLPATEPV----------DSSVSSSISAEEQFELPLELPS 2925

  Fly   356 DFS-------------KNKLQLIEDELDDAI----KNVLNKVDFTAQLSWSKTILQAKADHL-ER 402
            |.|             .::|.:|.|..:..:    |:|.:.....|.|  |..:..|...|: ..
Mouse  2926 DLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSEGDPALL--SPGVDPAPEGHMTPD 2988

  Fly   403 QFALADVELEKVQT----TADKMHCALYNS-------------CPVAHKHLPTLDIEPSDYV--- 447
            .|....::.:.:.:    :.::.|   .||             .||:    ||:.::...||   
Mouse  2989 HFIQGHMDADHISSPPCGSVEQGH---GNSQDLTRNSGTPGLQVPVS----PTVPVQNQKYVPSS 3046

  Fly   448 HEVPPPGEIVRPPIQLGETYY-AVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQM 511
            .:.|.|.:|....:|....:. ....|.|....:::.: :...|..||.|.|......:::...:
Mouse  3047 TDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPL-YVLQTLPNGVTQKIQLTSPVSSTPSV 3110

  Fly   512 IKTVTA---------------------------------------KHIAYF-------------- 523
            ::|.|:                                       :|:..|              
Mouse  3111 METNTSVLGPMGSGLTLTTGLNPSLPPSPSLFPPASKGLLSVPHHQHLHSFPAAAQSSFPPNISS 3175

  Fly   524 ---------EPPPVRLTIGTRVIAYFDGTT----------------LSRGKDKGVVQSAFYPGII 563
                     :|||....:|:......|.||                |...|:|.:..|: .|..|
Mouse  3176 PPSGLLIGVQPPPDPQLLGSEANQRTDLTTTVATPSSGLKKRPISRLHTRKNKKLAPSS-APSNI 3239

  Fly   564 AEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMV 628
            | |....:....:.|.....:.:....|:..:..:|.:...::...|:..|. |.|:..:..|  
Mouse  3240 A-PSDVVSNMTLINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIM-YFEQAPLLPP-- 3300

  Fly   629 QCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNH-----TEWIYRGSLRLGPVFRETQNN 688
            |...|.:.|...:.|                 ...|.:|     ...:..||..|..|..:|...
Mouse  3301 QSVGGTAATAAGSST-----------------ISQDTSHLTSGPVSALASGSSVLNVVSMQTTAA 3348

  Fly   689 MNSSSAQQLRVPRRTEPFI----------RYTKEMESSSKVNQQMRAFARKS--------SASAQ 735
            ..||::....|....:..:          ...|....|..:..|..|....|        |.:..
Mouse  3349 PTSSTSVPGHVTLANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPPSSGMFPQLGTSQTPS 3413

  Fly   736 NNALAAASS-------------AATPAG----------------GRT------------NAGGVS 759
            ..|:.||||             ||:|.|                |:|            :|.|..
Mouse  3414 AAAMTAASSICVLPSSQTAGMTAASPPGEAEEHYKLQRGNQLLAGKTGTLTSQRDRDPDSAPGTQ 3478

  Fly   760 TSN------SASAVRHLNNSTI------------------------YVDDENRPKGHVVYFTAKR 794
            .||      :.:.||...|.|:                        .|....:||.     .|||
Mouse  3479 PSNFTQTAEAPNGVRLEQNKTLPSAKPASSASPGSSPSSGQQSGSSSVPGPTKPKP-----KAKR 3538

  Fly   795 -NLP-----PKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVVY--KGPC 851
             .||     .|.:|......:....|.||  ...|..:|.::...|....|:....|..  :..|
Mouse  3539 IQLPLDKGSGKKHKVSHLRTSSEAHIPHR--DTDPAPQPSVTRTPRANREQQDAAGVEQPSQKEC 3601

  Fly   852 GK---SLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLV 913
            |:   .:.:|.||    :||:|..|             .:.:.:|..:::.     :...:.||:
Mouse  3602 GQPAGPVAALPEV----QATQNPAN-------------EQENAEPKAMEEE-----ESGFSSPLM 3644

  Fly   914 NYYDNTLPPPCTYAKQRIPTEGV--HLNLDEEFLLCCDCEDDC----SDK-----SKCACWQLTV 967
            .:.........:.. :|.|.:|:  .::.|:.|.:|.:..:|.    :||     |.....||:.
Mouse  3645 LWLQQEQKRKESIT-ERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSF 3708

  Fly   968 AGV-------------------------------RYCNPKK----PIEEIGYQYKRLH------- 990
            |||                               |:..|::    |:...|.....:|       
Mouse  3709 AGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFD 3773

  Fly   991 -------------EHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQ-------------VFKTS 1029
                         |:.|....|...:.|..:    |.....|.|.::             |:::.
Mouse  3774 MFNFLASKHRQPPEYNPNDEEEEEVQLKSAR----RATSMDLPMPMRFRHLKKTSKEAVGVYRSP 3834

  Fly  1030 NRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDH 1094
            ..|.||.|..:|..|..:..|||:::.....     |..::|:                      
Mouse  3835 IHGRGLFCKRNIDAGEMVIEYAGNVIRSIQT-----DKREKYY---------------------- 3872

  Fly  1095 SDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADL 1159
                   |:.|...         |.::                     :|..|            
Mouse  3873 -------DSKGIGC---------YMFR---------------------IDDSE------------ 3888

  Fly  1160 DETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVD--THDLRFPWVAFFS 1222
                                ::||...||..|:.||||.||.:.:.:.:|  .|      :..|:
Mouse  3889 --------------------VVDATMHGNAARFINHSCEPNCYSRVINIDGQKH------IVIFA 3927

  Fly  1223 AAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
            ...|..|.|||::|.:.:.....| |.|.|||..||
Mouse  3928 MRKIYRGEELTYDYKFPIEDASNK-LPCNCGAKKCR 3962

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 Tudor_SETDB1_rpt1 532..622 CDD:410453 19/105 (18%)
Tudor_SETDB1_rpt2 630..684 CDD:410548 9/58 (16%)
HMT_MBD 823..879 CDD:238689 14/60 (23%)
SET_SETDB1 900..1262 CDD:380915 74/440 (17%)
Kmt2aNP_001344478.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..106
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q03164 6..25
Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250|UniProtKB:Q03164 121..132
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..231
Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250|UniProtKB:Q03164 145..150
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..343
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..590
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..943
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1003
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1064
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1101..1161
zf-CXXC 1144..1191 CDD:366873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1196..1390
PHD1_KMT2A 1432..1478 CDD:277063
PHD2_KMT2A 1480..1529 CDD:277065
PHD3_KMT2A 1567..1626 CDD:277067
Interaction with histone H3K4me3. /evidence=ECO:0000250|UniProtKB:Q03164 1583..1599
Bromo_ALL-1 1649..1779 CDD:99925
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1665..1714
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1807..1870
ePHD_KMT2A 1873..1985 CDD:277163
FYRN 2026..2073 CDD:461787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2147..2174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2214..2339
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2371..2619 29/134 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2673 4/33 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2709..2759 7/49 (14%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:Q03164 2843..2851 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2958..3060 20/110 (18%)
Herpes_BLLF1 <3152..>3361 CDD:282904 39/230 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3164..3239 12/75 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3462..3640 36/206 (17%)
FYRC 3666..3749 CDD:197781 14/82 (17%)
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q03164 3759..3764 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3782..3805 4/26 (15%)
SET_KMT2A_2B 3813..3966 CDD:380947 46/253 (18%)
Blue background indicates that the domain is not in the aligned region.

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