DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and Nsd1

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_032765.3	Gene:	Nsd1 / 18193	MGIID:	1276545	Length:	2691	Species:	Mus musculus

Alignment Length:	1547	Identity:	286/1547 - (18%)
Similarity:	464/1547 - (29%)	Gaps:	615/1547 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SEAIAATGSTRKQCPYGGKAPDEPGK-LADESEDRKGENTKAI--------ASSPVLVAV----- 112
            |.|:|.|.:|.:.......:.|..|. ||:.|:..|||..|.:        .||.:..||
Mouse   796 SPAVAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVL 860

  Fly   113 --------------DSDSSVELIESPVKFSSANESEKDPPKPD-----------AVNEAAAKEAE 152
                          .|||.......|:.||||:.....|.:||           .::::..||..
Mouse   861 SELKELSYRSLSEDVSDSGTAKASKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQR 925

  Fly   153 EMTDSSISS-------PTSESFPEKDEKT----NKENEQEPPGMEVDQDVEESISRPAEEYKIEN 206
            .||..:::|       ..|...|....|.    :.....|.||......|.:|   |...   ::
Mouse   926 LMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEKPGDSTQDSVHQS---PGGG---DS 984

  Fly   207 TLKGHKRISLTEIEEHKIVDKKDDVLEVELEKGTAP-----KAAEDEKLNALLSDGDVFYDKECV 266
            .|.|....||:.:..    ||::.....::.....|     :|....||...:|...|   |..|
Mouse   985 ALSGELSSSLSSLAS----DKRELPACGKIRSNCIPRRNCGRAKPSSKLRETISAQMV---KPSV 1042

  Fly   267 NCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQLMA---------- 321
            |....|..::               ||.|:...:.:    .|..|..:.:|.:..
Mouse  1043 NPKALKTERK---------------RKFSRLPAVTL----AANRLGNKESGSVNGPSRGGAEDPG 1088

  Fly   322 -KQPL----LLKD----FHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDEL---DDAIK 374
             ::||    ||::    |...|.|..|..|..::..||:|   .|...|...:..|:   :|.:.
Mouse  1089 KEEPLQQMDLLRNEDTHFSDVHFDSKAKQSDPDKNLEKEP---SFENRKGPELGSEMNTENDELH 1150

  Fly   375 NVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEK----VQTTADKMHCALYNSCPVAHKH 435
            .| |:|  ..:..|.: :.|.:....:|.....:.|..:    |...||.:..|
Mouse  1151 GV-NQV--VPKKRWQR-LNQRRPKPGKRANRFREKENSEGAFGVLLPADAVQKA----------- 1200

  Fly   436 LPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAIN-GNTMKS 499
                   ..||:.:..||..  :|.....:..:...::::|..:::     .|.:::. |:..|.
Mouse  1201 -------REDYLEQRAPPTS--KPEDSAADPNHGSHSESVAPRLNV-----CEKSSVGMGDVEKE 1251

  Fly   500 YKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIA 564
            ..|     |..|.:|...:                                         |.|.:
Mouse  1252 TGI-----PSLMPQTKLPE-----------------------------------------PAIRS 1270

  Fly   565 EPLKQANRYRYLIFYDDGYTQ-YVPHRDVRLVCQASEKVWEDVHAASRDF--------IQKYVEK 620
            |..:.....::|:.|.:.|.| :.|.:       ..:||.|.||..|...        .|...:.
Mouse  1271 EKKRLRKPSKWLLEYTEEYDQIFAPKK-------KQKKVQEQVHKVSSRCEDESLLARCQPSAQN 1328

  Fly   621 YSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLG-PVFRE 684
            ..||...:..|:.:....|....:|...:...|..:         .|.|   ...|.|. ||..|
Mouse  1329 KQVDENSLISTKEEPPVLEREAPFLEGPLAQSDLGV---------THAE---LPQLTLSVPVAPE 1381

  Fly   685 TQNNMNSSSAQQL-RVP------RRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAA 742
            ........|.:.| :.|      |:.:|    ||::..|:.::...  ..:|...........|:
Mouse  1382 ASPRPALESEELLVKTPGNYESKRQRKP----TKKLLESNDLDPGF--MPKKGDLGLSRKCFEAS 1440

  Fly   743 SSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECS 807
            .|          ..|:..|.:.|.::..:..|..:.|:.|.:......||:.:     ||  :..
Mouse  1441 RS----------GNGIVESRATSHLKEFSGGTTKIFDKPRKRKRQRLVTARVH-----YK--KVK 1488

  Fly   808 PNCLFK---------IVHRLDSYSPLAKPLL-SGWERLVMRQKTKKSVVYKG------------- 849
            ...|.|         ::|| .:.||  |.:| .|.|.......:||..|.:|
Mouse  1489 KEDLTKDTPSSEGELLIHR-TAASP--KEILEEGVEHDPGMSASKKLQVERGGGAALKENVCQNC 1550

  Fly   850 ---------------------------PCGKSLRSLAEVHRYL-------RATENVLN------- 873
                                       |.||.:.:  |.|..:       ::.|:|..
Mouse  1551 EKLGELLLCEAQCCGAFHLECLGLPEMPRGKFICN--ECHTGIHTCFVCKQSGEDVKRCLLPLCG 1613

  Fly   874 ---------------VDNFDFTPDLK-CLAEYSIDPSIVKDTDISKGQEKMAIPL-VNYYDNTLP 921
                           ..|..|...|. |:..::.:|:   :...|||:....:.. |.|:.|..
Mouse  1614 KFYHEECVQKYPPTVTQNKGFRCPLHICITCHAANPA---NVSASKGRLMRCVRCPVAYHANDF- 1674

  Fly   922 PPCTYAKQRI-------------PTEGV----HLNLDEEF-------LLCCD-CE---------- 951
              |..|..:|             |..|.    |:|:...|       ||||| |.
Mouse  1675 --CLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNI 1737

  Fly   952 ---------DDCSDKSKCACWQLTVAGV-RY-------CNP------------------------ 975
                     :||....|....::....| ||       |:|
Mouse  1738 DIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGS 1802

  Fly   976 ---------------------------------KKPIEEIGYQYKRL------------------ 989
                                             ||.::|...:::.|
Mouse  1803 NDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKK 1867

  Fly   990 ---HEHV----PTG---IYECN----SRCKCK----------KNCLNRVVQFSLE---------- 1020
               ::|:    |.|   |:..:    .||.||          ..|:||::.:...
Mouse  1868 PPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRC 1932

  Fly  1021 ----------MKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADL 1075
                      ..:::|:|..||||||...||.||.|:..|.|.|:
Mouse  1933 QNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI-------------------- 1977

  Fly  1076 DYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQS 1140
                                              |:::.|....|
Mouse  1978 ----------------------------------DEEECRARIRY-------------------- 1988

  Fly  1141 SELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQN 1205
                :||..:.||. ...||             ||.   |:||...||..|:.||.|.||...|.
Mouse  1989 ----AQEHDITNFY-MLTLD-------------KDR---IIDAGPKGNYARFMNHCCQPNCETQK 2032

  Fly  1206 VFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNC 1257
            ..|: .|.|   |..|:.:.|::|||||:|||.|. :..||.: |:||||||
Mouse  2033 WSVN-GDTR---VGLFALSDIKAGTELTFNYNLEC-LGNGKTV-CKCGAPNC 2078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	17/125 (14%)
		Pre-SET	901..1013	CDD:282838	41/263 (16%)
		SET	1022..1239	CDD:214614	53/216 (25%)
Nsd1	NP_032765.3	MSH6_like	320..430	CDD:99898
		TNG2	<1453..1587	CDD:227367	25/145 (17%)
		PHD1_NSD1_2	1546..1587	CDD:277118	3/42 (7%)
		PHD2_NSD1	1593..1639	CDD:277120	4/45 (9%)
		PHD3_NSD1	1640..1693	CDD:277123	11/58 (19%)
		PHD4_NSD1	1710..1749	CDD:277126	7/38 (18%)
		WHSC1_related	1755..1849	CDD:99899	8/93 (9%)
		AWS	1902..1940	CDD:375420	3/37 (8%)
		SET_NSD1	1942..2083	CDD:380987	63/238 (26%)
		PHD5_NSD1	2121..2163	CDD:277129
		C5HCH	2162..2211	CDD:375464
		PHA03307	2255..>2576	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840