Protein Alignment egg and met-2

DIOPT Version :9

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_498848.4
• Gene: met-2 / 176183
• WormBaseID: WBGene00019883
• Length: 1304
• Species: Caenorhabditis elegans
• Alignment Length: 1436
• Identity: 365/1436 - (25%)
• Similarity: 568/1436 - (39%)
• Gaps: 445/1436 - (30%)

  Fly    86 GKLADESEDRKGENTKAI--ASSPVLVAVDSDSSVELIESPVKFSSANESEKDPPKPDAVNEAAA 148
            || |:|..|...:..:.|  |:|.|...:|:.|  |.:...:.....||||:         ||.|
 Worm    53 GK-AEEGTDEDSDLVEGILNANSDVQALLDAPS--EQVAQALNSFFGNESEQ---------EAVA 105

  Fly   149 KEAEEMTDSSISSPTSESFPEKDEKTNKENEQEPPGMEVDQDVEESISRPAEEYKIENTLKGHKR 213
              |:...|:..::        |||...|:.|:..     |..:|:||.:..||.:....||.::.
 Worm   106 --AQRRVDAEKTA--------KDEAELKQQEEAE-----DLIIEDSIVKTDEEKQAVRRLKINEF 155

  Fly   214 IS-LTEI--EEHK---------IVDKKDD--VLEVELEKGTAPKAAEDEKLNAL-----LSDGDV 259
            :| .|.:  |:.|         :.:...|  |:.|:..|.......|.|.|..|     |.|.||
 Worm   156 LSWFTRLLPEQFKNFEFTNPNYLTESISDSPVVNVDKCKEIVKSFKESESLEGLSQKYELIDEDV 220

  Fly   260 FYDKECV-------------NCNCTKLHKQYVLANMAT---------------LNFYQVLRKSSK 296
            .....|:             |..|......:.:....|               |.|.|....|..
 Worm   221 LVAAICIGVLDTNNEEDVDFNVLCDDRIDDWSIEKCVTFLDYPNTGLNSKNGPLRFMQFTVTSPA 285

  Fly   297 QQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSS----------------DE 345
            ...|.:    |.:.|.||       ..|..| ||..:..|.:.|:..                |:
 Worm   286 SAILML----TLIRLREE-------GHPCRL-DFDSNPTDDLLLNFDQVEFSNNIIDTAVKYWDD 338

  Fly   346 EEEEKQPEK-----SDF--------------------SKNK-LQLIEDELDD-----AIKNVLNK 379
            ::|....:|     :||                    |:|: :||:.:::.|     |..|....
 Worm   339 QKENGAQDKIGRELNDFFHEIESTSAEFKQHFENAVGSRNEIIQLVNEKIPDFDGTEAAVNESFT 403

  Fly   380 VDFTAQLSWSKTILQAKADHLERQFALADVELEKV---QTTADKMHCALYNSCPVAHKHLPTLDI 441
            .|...::..|:.|::.    |:.:..||..|.:||   :|..:|..........:|..:
 Worm   404 SDQRTEIINSRAIMET----LKAEMKLAIAEAQKVYDTKTDFEKFFVLTVGDFCLARAN------ 458

  Fly   442 EPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLN 506
             |||       ..|:         ||..|:::..|                     .:||:::::
 Worm   459 -PSD-------DAEL---------TYAIVQDRVDA---------------------MTYKVKFID 485

  Fly   507 TPYQMIKTVTAKHIA-----YFEPP-----PVRLTIGTRVI----------AYFDGTTLSRGKDK 551
            |  ..|:....:.:|     .::|.     .|.|.:..|.:          .:..||...|
 Worm   486 T--SQIRECNIRDLAMTTQGMYDPSLNTFGDVGLRVACRQVISSSQFGKKTIWLTGTAAGR---- 544

  Fly   552 GVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYV--------PHRDVRLVCQASEKV------ 602
                            ::|:|..:|||:|:|...||        |..:|     ||||.
 Worm   545 ----------------RRAHRSDFLIFFDNGTDAYVSAPTMPGEPGYEV-----ASEKKSVFSLK 588

  Fly   603 --------------------------------W-EDVHAAS--RDFIQKYVEKYSVDRP--MVQC 630
                                            | ...|.::  |||::::.|...:..|  |..|
 Worm   589 EMIAKMNAAQIAIMVGQPVGKEGNLDYFLTFHWIRQSHRSAYIRDFMKEFPEWPLLKMPVGMRIC 653

  Fly   631 ------TRGQSMTTESNGTWLYARVIDIDCSLVLMQFE----------------GDKNH---TEW 670
                  .|.:.|.|          ||..|.:..:::.|                .|:||   .|.
 Worm   654 LYNSLVDRRKKMVT----------VIGTDRAFAIVRHEAPNPLAPGNRCTDFPCNDRNHQHIDEK 708

  Fly   671 IYRGSLRL-GPVFRE----TQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKS 730
            |||||.|| |...::    |.||::.....||:  .:.||    |..:.|..:.|.| :...:|:
 Worm   709 IYRGSHRLEGAAHKKHMISTNNNLSQRRKDQLQ--SQFEP----TDMIRSMPERNHQ-QVVKKKT 766

  Fly   731 SASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVY------ 789
            :.:.||                     |:::|.|.:.|.:         |.|.|...::
 Worm   767 TGTNQN---------------------VASTNDAKSKREI---------EIRKKNQFLFNKIIVP 801

  Fly   790 ---FTAKRNLPPKMYKCH-ECSPNCLFKI--------VHRLDSYSPLAKPLLSGWERLVMRQKT- 841
               .|...||     |.| :|.|:||.|:        .||   .||:..|||.||.|::....|
 Worm   802 IPVLTPLENL-----KAHAQCGPDCLQKMDADPYEARFHR---NSPIHTPLLCGWRRIMYTMSTG 858

  Fly   842 ------KKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTD 900
                  ||:::|..|||.:|..:::|..|:..|.::|.:|.|.|...:......::|...:|..|
 Worm   859 KKRGAVKKNIIYFSPCGAALHQISDVSEYIHVTRSLLTIDCFSFDARIDTATYITVDDKYLKVAD 923

  Fly   901 ISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIP-TEGVHL-NLDEEFLLCCDCEDDCSDKSKCACW 963
            .|.|.|.:.|||||..||..||...|:|:|.. .:.|.: ::..:|...|.|:.||||.|||.|.
 Worm   924 FSLGTEGIPIPLVNSVDNDEPPSLEYSKRRFQYNDQVDISSVSRDFCSGCSCDGDCSDASKCECQ 988

  Fly   964 QLTVAGVRYCNPKKP-------IEEI--GYQYKRLHEHVPTGIYECNSRCKC-KKNCLNRVVQFS 1018
            ||::..::    :.|       .:|:  .||.:.|...|.:|:||||.:|.| :|:|.|||||.:
 Worm   989 QLSIEAMK----RLPHNLQFDGHDELVPHYQNRLLSSKVISGLYECNDQCSCHRKSCYNRVVQNN 1049

  Fly  1019 LEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQ 1083
            ::..:.:|||:..|||:|.:.|||:..|||.|.|.:||:.:|:|  ....|:||||||..:..|.
 Worm  1050 IKYPMHIFKTAQSGWGVRALTDIPQSTFICTYVGAILTDDLADE--LRNADQYFADLDLKDTVEL 1112

  Fly  1084 LK--EGYESEV----DHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKR--SSRSGSTQNSSTQS 1140
            .|  |.:|::.    |.||.|.||   |.|.:..||.     ..:.:||  ||.||......|:.
 Worm  1113 EKGREDHETDFGYGGDESDYDDEE---GSDGDSGDDV-----MNKMVKRQDSSESGEETKRLTRQ 1169

  Fly  1141 SELDSQERAVINFNPNADLDETVRENSVRR--LFGKDEAP------------YIMDAKTTGNLGR 1191
            ....|::...   ..:.:.|:|...:|:.:  :..|||..            |::|||..|||||
 Worm  1170 KRKQSKKSGK---GGSVEKDDTTPRDSMEKDNIESKDEPVFNWDKYFEPFPLYVIDAKQRGNLGR 1231

  Fly  1192 YFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPN 1256
            :.||||.||:.||:|..||||||.||||||:..::::|.||||:|.|.........|.|.|||.|
 Worm  1232 FLNHSCDPNVHVQHVMYDTHDLRLPWVAFFTRKYVKAGDELTWDYQYTQDQTATTQLTCHCGAEN 1296

  Fly  1257 CRLRLL 1262
            |..|||
 Worm  1297 CTGRLL 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	21/62 (34%)
		Pre-SET	901..1013	CDD:282838	44/123 (36%)
		SET	1022..1239	CDD:214614	90/238 (38%)
met-2	NP_498848.4	HMT_MBD	839..902	CDD:238689	21/62 (34%)
		PreSET	921..1035	CDD:128744	41/117 (35%)
		SET	1052..1278	CDD:214614	90/238 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159826
Domainoid	1	1.000	141	1.000	Domainoid score	I2929
eggNOG	1	0.900	-	-		E2759_KOG1141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18123
orthoMCL	1	0.900	-	-		OOG6_105124
Panther	1	1.100	-	-	LDO	PTHR46024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X219
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.700