Protein Alignment egg and Ezh1

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_031996.1
• Gene: Ezh1 / 14055
• MGIID: 1097695
• Length: 750
• Species: Mus musculus
• Alignment Length: 674
• Identity: 130/674 - (19%)
• Similarity: 215/674 - (31%)
• Gaps: 243/674 - (36%)

  Fly   612 DFIQKYVEKYSVDRPMV---QCT------------RGQSMTTESNGTWLYARVIDIDCSLVLMQF 661
            |..::|.|...:..|..   |||            |.||:  .|..|....|....||.|
Mouse   255 DMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSL--HSFHTLFCRRCFKYDCFL----- 312

  Fly   662 EGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRV---PRRTEPFIRYTKEMESSSKVNQQM 723
                 |.             |..|. |:.....:::::   |..|:.|:......|.:...|.:.
Mouse   313 -----HP-------------FHATP-NVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRS 358

  Fly   724 RAFARKS------SASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENR 782
            :...|:.      |||..|  .:|::.|.|..|......|...::|:|..    ||.....
Mouse   359 KCSGRRRRRHPVVSASCSN--ASASAMAETKEGDSDRDTGNDWASSSSEA----NSRCQTP---- 413

  Fly   783 PKGHVVYFTAKRNLPPKMYKCHECSPN----------CLFKIVH--RLDSYSPLAKPLLSGWERL 835
                    |.::..|.....|...:|:          .||::.|  ..:::..:|:.|.:...:.
Mouse   414 --------TKQKASPAPAQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQ 470

  Fly   836 VMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTD 900
            |.:...|:|::.|.|                 |:.::|       |..|...::.:..:..:...
Mouse   471 VFQFAVKESLILKLP-----------------TDELMN-------PAQKKKRKHRLWAAHCRKIQ 511

  Fly   901 ISKGQEKMAIPLVNYYDNTLPP-PCTYAKQRIPTEGVHLNLDEEFLLC----------CDCEDDC 954
            :.|  :..:..:.||.....|. ||......|.|:    |..|:|..|          |.|:..|
Mouse   512 LKK--DNNSTQVYNYQPCDHPDRPCDSTCPCIMTQ----NFCEKFCQCSPDCQNRFPGCRCKTQC 570

  Fly   955 SDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSL 1019
            :.| :|.|:    ..||.|:|...: ..|     ..||....:..|       |||   .:|..|
Mouse   571 NTK-QCPCY----LAVRECDPDLCL-TCG-----ASEHWDCKVVSC-------KNC---SIQRGL 614

  Fly  1020 EMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQL 1084
            :..|.:..:...|||......:.|..||..|.|.|:::..|:..|: ..|:|
Mouse   615 KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGK-VYDKY------------- 665

  Fly  1085 KEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERA 1149
                                                                  .||.|
Mouse   666 ------------------------------------------------------MSSFL------ 670

  Fly  1150 VINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLR 1214
               ||.|.|                    :::||...||..|:.|||.:||.:.:.|.|: .|.|
Mouse   671 ---FNLNND--------------------FVVDATRKGNKIRFANHSVNPNCYAKVVMVN-GDHR 711

  Fly  1215 FPWVAFFSAAHIRSGTELTWNYNY 1238
               :..|:...|::|.||.::|.|
Mouse   712 ---IGIFAKRAIQAGEELFFDYRY 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	3/9 (33%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	13/65 (20%)
		HMT_MBD	823..879	CDD:238689	9/55 (16%)
		SET_SETDB1	900..1262	CDD:380915	73/350 (21%)
Ezh1	NP_031996.1	EZH2_WD-Binding	42..71	CDD:463308
		PRC2_HTH_1	162..265	CDD:436286	3/9 (33%)
		SANT	436..477	CDD:238096	6/40 (15%)
		preSET_CXC	563..594	CDD:408079	11/41 (27%)
		SET_EZH1	611..746	CDD:380994	44/223 (20%)