Protein Alignment egg and Ehmt2

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_001390796.1
• Gene: Ehmt2 / 110147
• MGIID: 2148922
• Length: 1394
• Species: Mus musculus
• Alignment Length: 1376
• Identity: 277/1376 - (20%)
• Similarity: 446/1376 - (32%)
• Gaps: 441/1376 - (32%)

  Fly     1 MSG---QPTAVDCLE--------SSGSTVEDVQETPASREKSYGLP-VRKGENSLESPA------ 47
            |:|   .|.:|..|.        :.|:.....:.:||:.....|.| |.:...::..|:
Mouse   308 MTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPI 372

  Fly    48 -EQAAKDVE---IEELTHSEAIAATGSTRKQCPYG------GKAPDEPGKLADESEDRKGENTKA 102
             |:...:|:   :.:..|...:.:..:.|::...|      |.|......:.::.|.|..|..:.
Mouse   373 PEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWET 437

  Fly   103 IASS---------PVLVAVDSDSSVELIESPVKFSSANESEKDPPKPDAVNEAAAKEAEEMTDSS 158
            :...         .|...|||||..|:.....:.|...|.|::..:.:...|...:|.||..:|.
Mouse   438 VVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESG 502

  Fly   159 ISSPTSESFPEKDEK------------TNKENEQEPPGMEVDQDVE-ESISRPAE---------E 201
            ..|..|.|...:..|            :.|..::|||..:..:.|. ...|.|:|         |
Mouse   503 NQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLE 567

  Fly   202 YKIENTLK-GHKRISLTEIEEHKIVDKKDDVLEVELEKG-----------TAPK---AAEDEKLN 251
            ...|.||. .|..:|             :|...:|.|:|           .|||   .:|.....
Mouse   568 LPSEGTLSPNHAGVS-------------NDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHK 619

  Fly   252 ALLSDGDVFYDKECVNCNCTKLHKQYV--LANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEE 314
            .:.::.   .|.|.:.||...|.::.:  .:.:|.:...:..|....:...|.||.      |..
Mouse   620 CMATES---VDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCG------YFC 675

  Fly   315 YAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNK 379
            .||..:...|    ||...|.                     |.|            |..:.||.
Mouse   676 TAGTFLECHP----DFRVAHR---------------------FHK------------ACVSQLNG 703

  Fly   380 VDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTADKMHCALYNSCPVAHKHLPTLDI-EP 443
            :.|.....      :..::..|......|.....:.|.|..:.       |:||......|. :|
Mouse   704 MVFCPHCG------EDASEAQEVTIPRGDGGTPPIGTAAPALP-------PLAHDAPGRADTSQP 755

  Fly   444 SDYV--HEVPPPGEIVRPPIQ-LGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYL 505
            |..:  |     ||..|||.. |.:|       ..:|..|:        |..||..:.:     :
Mouse   756 SARMRGH-----GEPRRPPCDPLADT-------IDSSGPSL--------TLPNGGCLSA-----V 795

  Fly   506 NTPYQMIKTVTAKHIAYFE------PPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIA 564
            ..|....:....|.:...|      |||                  |..:.|   :..|:|..:.
Mouse   796 GLPPGPGREALEKALVIQESESPPSPPP------------------SPDRRK---KLRFHPRQLY 839

  Fly   565 EPLKQANRYRYLI---------FYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEK 620
            ..:||....:.::         |..|..::..|                 :|||:        :|
Mouse   840 LSVKQGELQKVILMLLDNLDPNFQSDQQSKRTP-----------------LHAAA--------QK 879

  Fly   621 YSVD--RPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFR 683
            .||:  ..::|.....:...:...|.|...|::              ||.| :.|..::||...
Mouse   880 GSVEICHVLLQAGANINAVDKQQRTPLMEAVVN--------------NHLE-VARYMVQLGGCV- 928

  Fly   684 ETQNNMNSSSAQQLRVPRRTEPFIRYTKEMESS------SKVNQQMRAFARKSSASAQNNALAAA 742
                                     |:||.:.|      :|:..........|:.....|
Mouse   929 -------------------------YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN----- 963

  Fly   743 SSAATPAGGRTNAGGVSTSNSASAVRHL---NNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCH 804
               |..:||.|.....:.......:|.|   .......|:|.....|...||....:...:...
Mouse   964 ---AQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA- 1024

  Fly   805 ECSPNCL-------FKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVH 862
            :|..:.:       ..|..| :||.......||......:|.|...:.....|....:....:::
Mouse  1025 QCDLHAVNYHGDTPLHIAAR-ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLN 1088

  Fly   863 RYLRATENVLNVDNFDF-TPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPC-- 924
            |.||     |.|.|... |..:.|             .|:::|.|.:.||.||..|.   .||
Mouse  1089 RKLR-----LGVGNRAVRTEKIIC-------------RDVARGYENVPIPCVNGVDG---EPCPE 1132

  Fly   925 --TYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYK 987
              .|..:...|..::::.:...|..|.|.|||| .|.|.|.||::.    |...|.    |...:
Mouse  1133 DYKYISENCETSTMNIDRNITHLQHCTCVDDCS-SSNCLCGQLSIR----CWYDKD----GRLLQ 1188

  Fly   988 RLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAG 1052
            ..::..|..|:|||..|.|.::|.|||||..::::||:::|:..|||:|.:..||:|.|||.|.|
Mouse  1189 EFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVG 1253

  Fly  1053 HLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPN 1117
            .|::                                         |||     .|..:||.:.
Mouse  1254 ELIS-----------------------------------------DAE-----ADVREDDSYL-- 1270

  Fly  1118 YHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMD 1182
                                                   .|||            .||...|.:|
Mouse  1271 ---------------------------------------FDLD------------NKDGEVYCID 1284

  Fly  1183 AKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKV 1247
            |:..||:.|:.||.|.||:....||:...|||||.:||||:..||:|.||.::|......:..|.
Mouse  1285 ARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKY 1349

  Fly  1248 LYCQCGAPNCR 1258
            ..||||:..|:
Mouse  1350 FTCQCGSEKCK 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	13/98 (13%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	9/53 (17%)
		HMT_MBD	823..879	CDD:238689	11/55 (20%)
		SET_SETDB1	900..1262	CDD:380915	101/363 (28%)
Ehmt2	NP_001390796.1	PHA03247	<126..379	CDD:223021	13/70 (19%)
		EHMT_ZBD	594..723	CDD:411018	28/180 (16%)
		ANKYR	838..1071	CDD:440430	48/308 (16%)
		ANK repeat	870..899	CDD:293786	8/53 (15%)
		ANK repeat	934..966	CDD:293786	5/39 (13%)
		ANK repeat	969..999	CDD:293786	4/29 (14%)
		ANK repeat	1001..1032	CDD:293786	5/31 (16%)
		ANK repeat	1034..1065	CDD:293786	6/31 (19%)
		SET_EHMT2	1132..1370	CDD:380931	91/337 (27%)