Protein Alignment egg and kmt2d

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_017947166.2
• Gene: kmt2d / 100494109
• XenbaseID: XB-GENE-855725
• Length: 6132
• Species: Xenopus tropicalis
• Alignment Length: 1552
• Identity: 280/1552 - (18%)
• Similarity: 455/1552 - (29%)
• Gaps: 604/1552 - (38%)

  Fly    35 PVRKGENSL-----ESPAEQAAKDVEIEE----LTHSEAIAATGSTRKQCPYGGKAPDEPGKLAD 90
            |.||.:.|.     ..|..|..|:...||    :.....:||.    |.|......|...|...|
 Frog  4853 PKRKTQESTAVCPQPVPTSQTTKNKSSEEHGGIIKPENNLAAV----KLCSSNLSPPSRDGPNPD 4913

  Fly    91 ESEDRKGENTKAIASSPVLVAV-DSD------SSVELIESPVKFSSANE-------------SEK 135
            .|     .:.:|.::||:|.:| :||      :|....|.|.:...:|:             |:.
 Frog  4914 SS-----SSIEASSASPMLSSVHESDAKPANTASFLPKEQPKESEPSNDISCQQSPATGDIHSDS 4973

  Fly   136 DPPKPDAVNEAAAKEAEEMTDSSISSPTSE-------SFPEKDEKTNKENEQEP--PGMEVDQDV 191
            ...||..:.|:.|  .:|....|:::|.|.       .||       |..:|||  .|:.|.||:
 Frog  4974 QVEKPGQITESDA--GKESNTKSLTNPNSHLENGEMADFP-------KFLKQEPIELGVSVQQDL 5029

  Fly   192 EESISRPAEEYKIENTLKGHK----RISL---------------------TEIEEHKIVDKKDDV 231
            :       .|...:||..|.|    .:.|                     ::|..|  :|.|..|
 Frog  5030 K-------SEANCDNTSLGAKTEAGHLLLQKLLRAKTCQLATQRSADPLHSDINGH--IDNKLTV 5085

  Fly   232 LEVELE-----------KGTAPKAAEDEKLNALLSDG-------DVFYDKECVNCNCTKLHKQYV 278
            ||.:|:           |...||....:|.|..:.:.       |.....:.:   ..:|.::..
 Frog  5086 LEQKLKAASRNQEDIAAKKAVPKPKRTQKTNERVPNSRKKIRREDSIKSPDAI---MKQLKQELS 5147

  Fly   279 LANMA----TLNF--YQVLRKSSKQQFLC--MGCHDT-AMDLYEEYAGQLMAKQ----------- 323
            |..:.    |.||  :.....||.....|  .|...: |::...:|..||::|.
 Frog  5148 LLPLVEPSITANFSLFAPFGSSSPVNGKCPLKGSFGSGALESIPDYYTQLLSKNNLSNPPTPPSS 5212

  Fly   324 --PLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELD----------DAIKNV 376
              |.......|...:.|.. :.|..:.:|:.|.|..:::|...:|..||          :..::|
 Frog  5213 LPPTPPPSVQQKMVNGVTA-AEDLSDAKKEAESSAETEDKKGTVERSLDLLAALPTPPHNQCEDV 5276

  Fly   377 LNKVDFTAQLSWS------------------KTILQAKADHLERQFALADVELEKVQTTADKMHC 423
            ..:.|..:.:..|                  .|:.:.|.:..||  ||:.|             .
 Frog  5277 RMESDEESDVPDSIVPASSPESVLGEETPRFPTLCEVKEEEEER--ALSPV-------------I 5326

  Fly   424 ALYNSCPVAHKHLPTL-DIEPSDYVHEVP-------------------PPGEIVRPPIQLGETYY 468
            .|...|.:     |.. |::|::.:..:|                   ..|..|...:.:.....
 Frog  5327 PLIPLCSI-----PVFPDVKPTETLEAIPEHSGKTLVTSAGGTVSWEKSKGSEVSVMLTVSAAAA 5386

  Fly   469 AVKN-----KAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMIK-TVTAKHIAYFEPPP 527
            |.|:     .|:|..:|||:             ..||::.:   |.:.:| ||..|..   |.|.
 Frog  5387 AAKSLNGVVAAVADLLSIKL-------------PSSYEVLF---PERGLKSTVQVKKP---EDPS 5432

  Fly   528 V-----RLTIG---------TRVIAYFDGTTLSRGKD---------KGVVQSAFY---------- 559
            .     |..:|         .::.|...|.||....|         ..|..||.:
 Frog  5433 TDGEKERSQLGKAENSTDWLKQLDAVLPGYTLKNELDILTLLTQEENAVENSAHHCYMNNVSNLD 5497

  Fly   560 ---------------------------------PGIIAEPL-------------------KQANR 572
                                             |.:..|||                   ||..|
 Frog  5498 VRQLPVLPEVSSPPPSPFVPSPATPGEPSAEPDPPVPLEPLPMPPTMSPDKEDCKDMAKIKQRAR 5562

  Fly   573 YRYLIFYDDGYTQYVPH----RDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMVQCTRG 633
            ..     :||..:..|.    :.||         |:.:|....  .||.|.::        |.:.
 Frog  5563 PP-----EDGIEEPKPRIKKWKGVR---------WKRLHILIT--FQKIVSRH--------CEKE 5603

  Fly   634 QSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTE------------WIYRGSLRLGPVFRETQ 686
            .....|..||.|....:..|........|.....|:            |::...........|||
 Frog  5604 ICEVIERLGTTLRPETLPPDLRKCCFCHEEGDGPTDGPGRLLNLDLDLWVHLNCALWSTEVYETQ 5668

  Fly   687 N----NMN-------------------SSSAQQLRVPR--------RTEPFIRYTKEM-----ES 715
            .    |:.                   ::|..:||.|.        |.:......|.|     :.
 Frog  5669 GGALINVEVALHRGLLTKCSLCQKTGATNSCNRLRCPNVYHFACAIRAKCMFFKDKTMLCPMHKL 5733

  Fly   716 SSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTN---AGGVSTSNSASAVRHL-----NN 772
            .....|::..|........:.:.::..:| ....|.|.:   .||:........:.|.     :.
 Frog  5734 KGPCEQELSCFTVFRRVYIERDEISQIAS-IIQRGDRIHMFRVGGLVFHAIGQLLPHQMQDFHSV 5797

  Fly   773 STIYVDDENRPKGHV---VYFTAKRNLPPKMYKCHECS----PNCLFKIVHR------LDSYSPL 824
            :.:|      |.|:.   :|::.:.:.....|:|..|.    |....:::..      |...||.
 Frog  5798 TALY------PVGYESTRIYWSMRHSHRRCCYRCRVCDNNGRPEFTVQVIEYGYEDVILTDSSPQ 5856

  Fly   825 AKPLLSGWERL---VMRQKTKKSVVYKGP---CGKSLRSLAEVHRYLRATENVLNVDNFDFTPDL 883
            |.     |.|:   |.|.:.:..::...|   .|:.:..|. ||..||..|::..|:|
 Frog  5857 AL-----WNRVAEPVARMRRETGMLRLFPEYLKGEEMFGLT-VHAVLRIAESLPGVEN------- 5908

  Fly   884 KC---LAEYSIDPSIVKDTDISKGQEKMAIPL-VNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEF 944
             |   |..|...|             .|.:|| :|      |..|..::.:|.|   |.......
 Frog  5909 -CQNYLFRYGKHP-------------LMELPLMIN------PTGCARSEPKIMT---HYKRPHTL 5950

  Fly   945 LLCCDCEDDCSDKSKCACWQLTVAG---VRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKC 1006
                      :..|....:|.|..|   ..|  .|:.:.....||:||.....|.:|...||.
 Frog  5951 ----------NSTSMSKAYQSTFTGETNTPY--SKQFVHSKSSQYRRLKTEWKTNVYLARSRI-- 6001

  Fly  1007 KKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEY 1071
                                    :|.||....|:.|...:..|.|.::..
 Frog  6002 ------------------------QGLGLYASKDLEKHTMVIEYIGTIIRN-------------- 6028

  Fly  1072 FADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNS 1136
                   |||.:.::.||
 Frog  6029 -------EVANRREKIYE----------------------------------------------- 6039

  Fly  1137 STQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNL 1201
                    .|.|.:..|..|.:                    :::||..||...||.||||:||.
 Frog  6040 --------EQNRGIYMFRINNE--------------------HVIDATLTGGPARYINHSCAPNC 6076

  Fly  1202 FVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
            ..:.|..|..|.    :...|:..|..|.|||::|.::......|: .|.|||.|||
 Frog  6077 VAEVVTFDKEDK----IIIISSRRIPKGEELTYDYQFDFEDDQHKI-PCHCGAWNCR 6128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	26/173 (15%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	9/65 (14%)
		HMT_MBD	823..879	CDD:238689	16/61 (26%)
		SET_SETDB1	900..1262	CDD:380915	69/363 (19%)
kmt2d	XP_017947166.2	ePHD1_KMT2D	126..209	CDD:277165
		PHD1_KMT2C_like	220..265	CDD:276984
		PHD2_KMT2D	267..312	CDD:277070
		PHD3_KMT2D	808..858	CDD:277072
		PHD5_KMT2C_like	859..905	CDD:276988
		PHD5_KMT2D	936..986	CDD:277074
		HMG-box_KMT2D	1435..1518	CDD:438836
		PHA03307	1745..>2115	CDD:223039
		PHA03307	1975..>2261	CDD:223039
		ePHD2_KMT2D	5627..5733	CDD:277168	14/105 (13%)
		FYRN	5776..5818	CDD:461787	7/47 (15%)
		FYRC	5835..5922	CDD:197781	22/113 (19%)
		SET_KMT2C_2D	5979..6131	CDD:380948	54/277 (19%)