Protein Alignment egg and setdb1

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_001238764.2
• Gene: setdb1 / 100490309
• XenbaseID: XB-GENE-853380
• Length: 1282
• Species: Xenopus tropicalis
• Alignment Length: 1421
• Identity: 402/1421 - (28%)
• Similarity: 590/1421 - (41%)
• Gaps: 501/1421 - (35%)

  Fly   200 EEYKIENTLKGHKRISLTEIEEHKIVDKKDDVLE---------VELEKGTAPKAAEDEKLNALLS 255
            |..::|..:.....||:.::  |:::|::.:.:|         :|||:....|.||.:.::.|..
 Frog     5 ETMELEQMVVKELGISMDDL--HELIDRELEKIEFVKQRKAQLLELEQLVKQKEAEVDHVDKLFD 67

  Fly   256 DGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQLM 320
            :.....|      :|..|.|          :.|..:..:.|
 Frog    68 NATRAVD------DCEMLVK----------SLYNQIGMTYK------------------------ 92

  Fly   321 AKQPLLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIE--DELDDAIKNV-----LN 378
                                :||.|:|...:|         :::||  ||.||.:.:|     ::
 Frog    93 --------------------ESSSEDEGSSKP---------VEVIEIPDEDDDDVMSVGSGEAVS 128

  Fly   379 KVDFTAQLSWSKTILQAKADHLERQFALA------DVE--LEKVQTTADKMHCALYNSCPVAHKH 435
            |:              .|..||.|:...|      ||:  :|.:|..:|......     .:|..
 Frog   129 KI--------------PKEKHLLREAMAAMKRSRQDVQSIVEAIQKKSDGPQTRF-----SSHPS 174

  Fly   436 LPTLDIEPSDYV---HEVPPPGEIVRPPIQLGETYYAVKNKAIASW-----VSIKVIEFTESTAI 492
            .||..:..|:..   :::...|::|.....||:       |...:|     :||:.:
 Frog   175 SPTSSVGGSNQASASNDMSKDGDLVVGMRILGK-------KRTKTWHKGTLISIQCV-------- 224

  Fly   493 NGNTMKSYKIRYLNTPYQMIKTVTAKHIAY-FEPPPVRLTIGTRVIA-YFDGTTLSRGKDKGVVQ 555
              ...|.||:::.|....::   :..|||| :.|||..|.:|:||:| |.||.           |
 Frog   225 --GPGKKYKVKFDNKGKSLL---SGNHIAYDYHPPPENLVVGSRVVAKYKDGN-----------Q 273

  Fly   556 SAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAAS-RDFIQKYVE 619
            ...|.||:|||....|:.|||||:||||..||.|.::..||:.....|||:...| |||||:||.
 Frog   274 VWLYAGIVAEPPSNKNKMRYLIFFDDGYASYVTHAELYPVCRPLISSWEDIEDVSCRDFIQEYVN 338

  Fly   620 KYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRE 684
            .|. :||||....||.:.||..|||..::|.::|.|||.:.|..|| ..|||||||.||.|:|
 Frog   339 AYP-NRPMVLLKSGQLIKTEWEGTWWKSKVEEVDGSLVKILFLDDK-RCEWIYRGSTRLEPMF-- 399

  Fly   685 TQNNMNSSSA---------QQLRVP-----RRTEPFIRYTKEM---------------------- 713
               :|.:|:|         ||...|     |...|.::||.::
 Frog   400 ---SMKTSTASTQEKKQAGQQRTRPNVGAIRSKGPVVQYTHDLTGSEPEPKPAAPPSPLSIPSPQ 461

  Fly   714 ----ESSSKVNQQMRAFARKSSA-------SAQNNALAAASSAATPAGG--------RTNAG--- 756
                :|.|:..|..:..|:||::       |.|::.:.:.|....|...        ::|..
 Frog   462 LIDTDSDSQQAQSKKQVAKKSTSFRPGSAGSGQSSPIPSESVPPPPPPPPPVVQRPFQSNQSVQP 526

  Fly   757 -----------------GVSTSNSASAVRHLNN----------STIYVDDENRPKGHV--VYFTA 792
                             |:.|..:...::.:..          .||.....||....:  ::...
 Frog   527 VQSIQSIQNIQTIQTIQGIQTIQAIQPIQTIQTLQPIQTIQPLQTIQTLQGNRIVTSIQQIHIIQ 591

  Fly   793 KRNLP-------PK---MYKCHECSPNCLFKI---VHRLDSYSPLAKPLLSGWERLVMRQKTKKS 844
            ..|:|       ||   .|..|.|:..||.:|   .||  ..:||..|||..:.|:..|::..:.
 Frog   592 AENVPAETTYKAPKEKLFYLPHVCNYTCLSRIRPVSHR--GKNPLLVPLLYDFRRMTARRRVNRK 654

  Fly   845 ----VVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKD------- 898
                |:||.|||.|||::.|:.|||           |:....:..|..:.:||.::.|
 Frog   655 MGFHVIYKTPCGLSLRTMPEIERYL-----------FEVECRMLFLEMFCLDPYVLVDRKFQPQK 708

  Fly   899 -----TDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKS 958
                 .||:.|:|.:.:..||..|.|.||...|:|:|||.:||.:|...|:|:.|||.|.|.|||
 Frog   709 PFYYIPDITYGKEDVPLSCVNEIDRTPPPQVAYSKERIPGKGVFINTGAEYLVGCDCTDGCRDKS 773

  Fly   959 KCACWQLTVAGVRYCNPKKPIEEI-GYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEM 1021
            ||||.|||:.... |.|...:..: |||:|||.|.:|||:||||.||||..| |.||:||..|::
 Frog   774 KCACHQLTIQATG-CTPGAQLNPMAGYQHKRLEECLPTGVYECNKRCKCSANMCNNRLVQHGLQV 837

  Fly  1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKE 1086
            :||:|||.|:|||:||::||.||:|:|||||.:||:..|::.|.:.||||||:||:||..|..||
 Frog   838 RLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENYKE 902

  Fly  1087 GYESE---------VDHSDPDAEEDNGGPDAED-----DDDFRPN-----------YHYQRKIKR 1126
            ||||:         ||..|.| ||:.|..|.::     ||:|..|           |..:|:.:.
 Frog   903 GYESDAKSSSDSSGVDLKDDD-EENTGSEDQDESNDSSDDNFGKNEDITTSSVWRSYATRRQTRG 966

  Fly  1127 SSRSGSTQNSSTQS------------------------------------SELDSQERA------ 1149
            ...:|:::.:|..|                                    |.:||..|:
 Frog   967 QKENGTSETASKDSALARQTSQDETTDCKLPEETSKNKVASWLSSNTMADSLMDSDSRSSLKMGD 1031

  Fly  1150 ------------------------VINFNP----------------------------------- 1155
                                    :..:||
 Frog  1032 ASETDKPKESDEASKYPGFGEGNRMYGYNPAPAKKDGVRRPVSKTALHQNKRQSNSAQPTDEVLT 1096

  Fly  1156 ------------------------------------NADLDE----------------------- 1161
                                                .:|.:|
 Frog  1097 LSSSSESEVGSGTNGTKKPAAQATANDSDDIQTISSGSDEEEEKKNVATTAGPVKRQVAVKSTRG 1161

  Fly  1162 ---------TVREN-----------SVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNV 1206
                     ||:.|           :.|:.|..:|:.||:|||..||||||.|||||||||||||
 Frog  1162 FALKSTHGITVKTNMASGEGGTGRRNTRQFFDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNV 1226

  Fly  1207 FVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL 1262
            |||||||||||||||::..||:||||||:||||||.|.||.|.|.||:..||.|||
 Frog  1227 FVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKKLLCCCGSTECRGRLL 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	40/91 (44%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	26/53 (49%)
		HMT_MBD	823..879	CDD:238689	21/59 (36%)
		SET_SETDB1	900..1262	CDD:380915	198/568 (35%)
setdb1	NP_001238764.2	DUF5604	193..250	CDD:408109	15/76 (20%)
		Tudor_SETDB1_rpt1	260..341	CDD:410453	40/91 (44%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	26/58 (45%)
		SP1-4_N	<515..>594	CDD:425404	7/78 (9%)
		MBD	631..706	CDD:128673	25/85 (29%)
		SET_SETDB1	708..>905	CDD:380915	101/197 (51%)
		MSCRAMM_ClfA	<903..>1045	CDD:468110	25/142 (18%)
		SET	<1193..1282	CDD:394802	64/88 (73%)