Protein Alignment egg and ehmt2

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_004917185.1
• Gene: ehmt2 / 100484992
• XenbaseID: XB-GENE-487387
• Length: 1150
• Species: Xenopus tropicalis
• Alignment Length: 1372
• Identity: 269/1372 - (19%)
• Similarity: 443/1372 - (32%)
• Gaps: 488/1372 - (35%)

  Fly   121 IESPV----KFSSANESEKDP-PKPDAVNEAAA-----KEAEEMTDSSISSPTSESFPEKDEKTN 175
            :|:|.    :..||..::|:. |:.|.|..:|:     ..|||::::...|| ::..|..:||..
 Frog     1 MEAPAGESERMLSAEGADKEGCPERDLVGLSASINSGDDNAEELSNTREISP-ADVIPTVEEKEE 64

  Fly   176 KENEQ---EPPGMEVDQDVEESISRPAEEYKIENTLKGHKRISLT----------EIEEHKIVDK 227
            .|.|.   .|.|..:.....:|:..|..  ...:.:....::|||          .:....:...
 Frog    65 TEKESVNISPVGRGLSGHASKSLPTPPS--TSSSPISSRAKMSLTGTGKLPHAAQSLAMRLLNIT 127

  Fly   228 KDDVLEVELEKGTAPKAAEDEKLNALLSDGDVFYDKECVNCNCTKLHKQYVL--ANMATLNFYQV 290
            :|...:|...:.|.|:|........|:|||:                ||.|.  :.|.|.:....
 Frog   128 RDGADKVHRARKTIPRAVNVPGNGVLVSDGE----------------KQSVRRESEMETRDSPDS 176

  Fly   291 LRKSSKQQFLCMGCHDTAMDL---------------------YEEYAGQLMAKQPLLLKDFH-QD 333
            .:|.|....:.....:.:.::                     .||:..::.|:..|....|. ::
 Frog   177 TQKRSSSSLVADISANQSREVEVSSLLLSPEPGSSRDPEGVDAEEWEPEVGAEFSLFYDSFSLEE 241

  Fly   334 HADFVALDSSDEEEEEK-----QPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTIL 393
            ..|   .||.:||:||:     |.|:|..|..|....:.::|.|               |.|...
 Frog   242 QGD---SDSKEEEDEEEEGSGNQSERSSSSMKKKTKKKWKMDKA---------------WLKPTR 288

  Fly   394 QAKADHLERQF-ALADVELEKVQTTADKMHCALYNSCPVAHKHLP---------------TLDIE 442
            :.|....|:.. |::.|.:...:          |...|:....||               |..::
 Frog   289 KRKRREREKPVTAVSSVGVSNSE----------YTEVPLGALDLPSEGTLSPNHAGVCNETSSMD 343

  Fly   443 PSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTES----------TAINGNTM 497
            ...| .|:|.....:..| .:........|..:|          |||          |.....||
 Frog   344 TERY-EELPLCSCRMEAP-SVDRVCEQANNMCMA----------TESVDGELSGCNVTITKRETM 396

  Fly   498 K------------SYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGT--------RVIAYFDG 542
            :            |::.|       |:|........||      .|.||        |:...|..
 Frog   397 RPSSRVPLMVLCESHRAR-------MVKHHCCPGCGYF------CTTGTFLECHPDFRINHRFHK 448

  Fly   543 TTLSR----------GKDKG-----VVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRD- 591
            ..:|.          |:|..     .:..|..|..|..|                     ||.|
 Frog   449 ACVSPLNGIIFCPHCGEDASEAEQITIAKADTPVPIPAP---------------------PHHDG 492

  Fly   592 --------------VRLVCQASEKVWED------------VHAA------------SRDFIQKYV 618
                          :|.|.:......|:            :|:.            :||.::|.:
 Frog   493 GGPGRADTTQPSARMRGVGEGKRSALENTSNEEPQGPSVLLHSGVYLSTAGLPPGHARDALEKAL 557

  Fly   619 EK------------YSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWI 671
            :.            :|:...::|..|.:......|...||..|...:...||:... |...:.::
 Frog   558 QSQETDSLLQGRNCHSLTESLLQQKRDRRKKIRYNSRQLYLSVKQGELQKVLLMLM-DNQDSNFL 621

  Fly   672 --------------YRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIR-------------- 708
                          .||||.|..:..:...::||:. :.||.| ..|..:.
 Frog   622 NDQQLKRSPLHAAAQRGSLELCHILVQAGASINSTD-KVLRTP-LLEAVVNNHIDIAKYLVQCGA 684

  Fly   709 --YTKEMESSSKV-------NQQMRAFARKS---SASAQNNALAAASSAATPAGGRTNAGGVSTS 761
              |.||.:.|:.:       |.::..|...:   :.:||:|            ||.|.....:..
 Frog   685 CVYHKEEDGSTCLHHAAKSGNLELLCFLLSTGQVNVNAQDN------------GGWTPIIWAAEH 737

  Fly   762 NSASAVRHL---NNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSY-- 821
            .....:|.|   .......|:|.....|...||....:...:... :|.       :|.::.:
 Frog   738 KHIDVIRTLLTRGADVTLQDNEKNICLHWASFTGSAEIAEVLLNA-QCD-------LHAVNFHGD 794

  Fly   822 SPLAKPLLSGWERLV-----------MRQKTKKSVVYKGPCGKSLRS-----LAEVHRYLR---- 866
            :||......|:.:.|           :|.....:     ||..:|..     ..:::|.:|
 Frog   795 TPLHIASREGFIQCVNLFLSRGADTEIRNNEGDT-----PCDLTLEHTDVWYALQLNRKIRQGIN 854

  Fly   867 ----ATENVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTL-PPPCTY 926
                .||.:::                         .||:.|.|::.||.||..|..| |....|
 Frog   855 NRAVRTERIIS-------------------------RDIAHGYERVPIPCVNGVDEELCPDDYKY 894

  Fly   927 AKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHE 991
            ..:...|..:.::.:...|..|.|.|||| .|.|.|.||::.    |...|.    |...:..::
 Frog   895 VSENCETSAMSIDRNITHLQNCSCVDDCS-SSNCLCGQLSIR----CWYDKD----GRLLQEFNK 950

  Fly   992 HVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLT 1056
            ..|..|:|||..|.|.:.|.|||||..::::||:::|:..|||:|.:..||:|.|||.|.|.|::
 Frog   951 IEPPLIFECNQACSCWQTCKNRVVQSGIKVRLQLYRTAKMGWGVRALQAIPQGTFICEYVGELIS 1015

  Fly  1057 ETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQ 1121
                                                     |||     .|..:||.:.
 Frog  1016 -----------------------------------------DAE-----ADVREDDSYL------ 1028

  Fly  1122 RKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTT 1186
                                               .|||            .||...|.:||:..
 Frog  1029 -----------------------------------FDLD------------NKDGEVYCIDARYY 1046

  Fly  1187 GNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQ 1251
            ||:.|:.||.|.|||....||:...|||||.:||||...||:|.||.::|......:..|...||
 Frog  1047 GNVSRFINHLCEPNLIPVRVFMSHQDLRFPRIAFFSGRDIRAGEELGFDYGDRFWDIKSKYFTCQ 1111

  Fly  1252 CGAPNCR 1258
            ||:..|:
 Frog  1112 CGSERCK 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	21/163 (13%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	13/67 (19%)
		HMT_MBD	823..879	CDD:238689	12/79 (15%)
		SET_SETDB1	900..1262	CDD:380915	103/360 (29%)
ehmt2	XP_004917185.1	EHMT_ZBD	348..477	CDD:411018	25/152 (16%)
		ANKYR	574..861	CDD:440430	51/314 (16%)
		ANK repeat	628..657	CDD:293786	7/28 (25%)
		ANK repeat	659..690	CDD:293786	5/31 (16%)
		ANK repeat	692..724	CDD:293786	4/31 (13%)
		ANK repeat	727..757	CDD:293786	4/29 (14%)
		ANK repeat	759..790	CDD:293786	6/38 (16%)
		ANK repeat	792..823	CDD:293786	4/30 (13%)
		SET_EHMT2	890..1128	CDD:380931	92/337 (27%)