DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and Kmt2d

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_017450810.1	Gene:	Kmt2d / 100362634	RGDID:	2324324	Length:	5544	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	95/497 - (19%)
Similarity:	148/497 - (29%)	Gaps:	204/497 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 VYFTAKRNLPPKMYKCHECS-------PNCLFKIVHR------LDSYSPLAKPLLSGWERLV--- 836
            :|::.:.|   ....|:.||       |..:.|::.:      ....||.|.     |.|::
  Rat  5222 IYWSLRTN---NRRCCYRCSISENNGRPEFVIKVIEQGLEDLVFTDASPQAV-----WNRIIEPV 5278

  Fly   837 --MRQKTKKSVVYKGPC-GKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKC---LAEYSIDPSI 895
              ||::.....::.... |:.|..|. ||..||..|::..|::        |   |..|...|
  Rat  5279 AAMRKEADMLRLFPEYLKGEELFGLT-VHAVLRIAESLPGVES--------CQNYLFRYGRHP-- 5332

  Fly   896 VKDTDISKGQEKMAIPL-VNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSK 959
                       .|.:|| :|      |..|..::.:|.|   |.......          :..|.
  Rat  5333 -----------LMELPLMIN------PTGCARSEPKILT---HYKRPHTL----------NSTSM 5367

  Fly   960 CACWQLTVAG---VRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEM 1021
            ...:|.|..|   ..|  .|:.:.....||:||.......:|...||.
  Rat  5368 SKAYQSTFTGETNTPY--SKQFVHSKSSQYRRLRTEWKNNVYLARSRI----------------- 5413

  Fly  1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKE 1086
                     :|.||....|:.|...:..|.|.::..                     |||.:.::
  Rat  5414 ---------QGLGLYAAKDLEKHTMVIEYIGTIIRN---------------------EVANRREK 5448

  Fly  1087 GYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVI 1151
            .||                                                       .|.|.:.
  Rat  5449 IYE-------------------------------------------------------EQNRGIY 5458

  Fly  1152 NFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFP 1216
            .|..|.:                    :::||..||...||.||||:||...:.|..|..|.
  Rat  5459 MFRINNE--------------------HVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDK--- 5500

  Fly  1217 WVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
             :...|:..|..|.|||::|.::......|: .|.|||.|||
  Rat  5501 -IIIISSRRIPKGEELTYDYQFDFEDDQHKI-PCHCGAWNCR 5540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	15/61 (25%)
		Pre-SET	901..1013	CDD:282838	22/115 (19%)
		SET	1022..1239	CDD:214614	38/216 (18%)
Kmt2d	XP_017450810.1	ePHD1_KMT2D	134..217	CDD:277165
		PHD1_KMT2C_like	228..273	CDD:276984
		PHD_SF	275..320	CDD:304600
		PHD3_KMT2D	1335..1385	CDD:277072
		PHD5_KMT2C_like	1386..1432	CDD:276988
		PHD5_KMT2D	1463..1513	CDD:277074
		HMG	1979..2030	CDD:197700
		ePHD2_KMT2D	5039..5145	CDD:277168
		FYRN	5189..5239	CDD:283589	4/19 (21%)
		FYRC	5247..5334	CDD:197781	21/113 (19%)
		SET	5404..5526	CDD:214614	41/247 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930