Protein Alignment egg and Setdb2

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_038949803.1
• Gene: Setdb2 / 100361710
• RGDID: 2319564
• Length: 1008
• Species: Rattus norvegicus
• Alignment Length: 790
• Identity: 217/790 - (27%)
• Similarity: 322/790 - (40%)
• Gaps: 236/790 - (29%)

  Fly   580 DDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMV-QCTRGQSMTTESNGT 643
            |||...::..:...::....:|: :|..|.:.|::|..|        :| :.|...|.|.|
  Rat    17 DDGKVDFMFEKAQDVLHSLKQKI-KDGSATNGDYVQAMV--------LVNEATLSNSQTLE---- 68

  Fly   644 WLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIR 708
                                 |:||           ||   |||
  Rat    69 ---------------------KDHT-----------PV---TQN--------------------- 77

  Fly   709 YTKEMESSSKVNQQMRAFARKSSASAQNNA------LAAASSAATPAGGRTNAGGVSTSNSASAV 767
               |.::.|.|         ..|.|.:|.:      |:.......|...:|...|
  Rat    78 ---EQKNKSNV---------FPSTSCENPSPEDCIILSTGRKGFLPVNNKTEGSG---------- 120

  Fly   768 RHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGW 832
                        |..|..|.            .:..|.||..||.:....|...:||..||...:
  Rat   121 ------------EKEPPLHA------------SFHHHVCSSACLREAPLSLKGENPLQLPLRCHF 161

  Fly   833 ERLVMRQKTKKS---VVYKGPCGKSLRSLAEVHRYLRATE-NVLNVDNFDFTPDLKCLAEYSIDP 893
            :|...:..:..:   |.|:.|||:|||::.||..||..|| |.|..|||.|...::....:....
  Rat   162 QRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYVQLTRNHPKQN 226

  Fly   894 SIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKS 958
            .:|.|.|||.|.|.::|...|..||:..|...| :..:.....|||:...|...|||.:.|.|..
  Rat   227 EVVSDVDISNGVESVSISFCNEVDNSKLPQFKY-RTTVWPRAYHLNVSSMFSDSCDCSEGCIDIK 290

  Fly   959 KCACWQLTVAGVRYCNPKKPIEE-IGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEM 1021
            ||||.|||....:.| |..|..| .||:||||...:|:||||||..|||.:. |.|||:|....:
  Rat   291 KCACLQLTAKNAKAC-PLSPDGECTGYKYKRLQRLIPSGIYECNLFCKCNRQMCQNRVIQHGPRV 354

  Fly  1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLL---TETMANEGGQDAGDEY-----FADLDYI 1078
            :|||||:..:|||:||::||.||.|:|||:|.||   |....|.|..::..::     |:....|
  Rat   355 RLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEKTNIGESESEQQHTVKNSFSKKRKI 419

  Fly  1079 EV--------AEQLK-EG----YESEVD----------------HS---DPDAEED--------- 1102
            ||        .|..| ||    :.|:::                ||   .|.::.|
  Rat   420 EVVCSDRQTHCESPKTEGCPPKFSSDLEEPVVEMNNRNISRTQRHSVIRRPKSKTDVFHYNEKNM 484

  Fly  1103 ------NGGPDAEDDDDFRP-NYHYQRKIKR------SSRSGSTQNSS-TQSSELDS-------- 1145
                  :..|  |:.:.|:| ..|...|.:|      ||:.|.:::.. |:|..:|:
  Rat   485 GFVCSYSAAP--EEKNGFKPAQEHLDSKARRAHEDLSSSQVGYSEDKQLTESDVIDTTTSREDTS 547

  Fly  1146 -----QERAVINFN----------PNADLDETVRENSVRRLFGKD------------------EA 1177
                 :..|::|..          ..:..:|.....|.:...|::                  |:
  Rat   548 PAYGCKHAAILNSKNTKKVLEVPVKTSQEEEPAASQSQQVSCGEELASERTKIPSASLVQLSKES 612

  Fly  1178 PYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGV 1242
            .:::||...||:||:.||||.|||:||||||:|||..||..|||:..::::.|||||:|.||.|.
  Rat   613 LFLLDASKEGNVGRFLNHSCYPNLWVQNVFVETHDRNFPLAAFFTNRYVKARTELTWDYGYEAGT 677

  Fly  1243 VPGKVLYCQC 1252
            :|.|.:.|||
  Rat   678 MPEKEILCQC 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	9/41 (22%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	9/53 (17%)
		HMT_MBD	823..879	CDD:238689	24/59 (41%)
		SET_SETDB1	900..1262	CDD:380915	149/459 (32%)
Setdb2	XP_038949803.1	HMT_MBD	152..212	CDD:238689	24/59 (41%)
		SET	210..687	CDD:394802	151/480 (31%)
		SET	365..>425	CDD:459965	23/59 (39%)
		PHD_SF	700..813	CDD:473978