DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and Setdb2

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_038949803.1	Gene:	Setdb2 / 100361710	RGDID:	2319564	Length:	1008	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	217/790 - (27%)
Similarity:	322/790 - (40%)	Gaps:	236/790 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 DDGYTQYVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSVDRPMV-QCTRGQSMTTESNGT 643
            |||...::..:...::....:|: :|..|.:.|::|..|        :| :.|...|.|.|
  Rat    17 DDGKVDFMFEKAQDVLHSLKQKI-KDGSATNGDYVQAMV--------LVNEATLSNSQTLE---- 68

  Fly   644 WLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIR 708
                                 |:||           ||   |||
  Rat    69 ---------------------KDHT-----------PV---TQN--------------------- 77

  Fly   709 YTKEMESSSKVNQQMRAFARKSSASAQNNA------LAAASSAATPAGGRTNAGGVSTSNSASAV 767
               |.::.|.|         ..|.|.:|.:      |:.......|...:|...|
  Rat    78 ---EQKNKSNV---------FPSTSCENPSPEDCIILSTGRKGFLPVNNKTEGSG---------- 120

  Fly   768 RHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGW 832
                        |..|..|.            .:..|.||..||.:....|...:||..||...:
  Rat   121 ------------EKEPPLHA------------SFHHHVCSSACLREAPLSLKGENPLQLPLRCHF 161

  Fly   833 ERLVMRQKTKKS---VVYKGPCGKSLRSLAEVHRYLRATE-NVLNVDNFDFTPDLKCLAEYSIDP 893
            :|...:..:..:   |.|:.|||:|||::.||..||..|| |.|..|||.|...::....:....
  Rat   162 QRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYVQLTRNHPKQN 226

  Fly   894 SIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKS 958
            .:|.|.|||.|.|.::|...|..||:..|...| :..:.....|||:...|...|||.:.|.|..
  Rat   227 EVVSDVDISNGVESVSISFCNEVDNSKLPQFKY-RTTVWPRAYHLNVSSMFSDSCDCSEGCIDIK 290

  Fly   959 KCACWQLTVAGVRYCNPKKPIEE-IGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEM 1021
            ||||.|||....:.| |..|..| .||:||||...:|:||||||..|||.:. |.|||:|....:
  Rat   291 KCACLQLTAKNAKAC-PLSPDGECTGYKYKRLQRLIPSGIYECNLFCKCNRQMCQNRVIQHGPRV 354

  Fly  1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLL---TETMANEGGQDAGDEY-----FADLDYI 1078
            :|||||:..:|||:||::||.||.|:|||:|.||   |....|.|..::..::     |:....|
  Rat   355 RLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEKTNIGESESEQQHTVKNSFSKKRKI 419

  Fly  1079 EV--------AEQLK-EG----YESEVD----------------HS---DPDAEED--------- 1102
            ||        .|..| ||    :.|:::                ||   .|.::.|
  Rat   420 EVVCSDRQTHCESPKTEGCPPKFSSDLEEPVVEMNNRNISRTQRHSVIRRPKSKTDVFHYNEKNM 484

  Fly  1103 ------NGGPDAEDDDDFRP-NYHYQRKIKR------SSRSGSTQNSS-TQSSELDS-------- 1145
                  :..|  |:.:.|:| ..|...|.:|      ||:.|.:::.. |:|..:|:
  Rat   485 GFVCSYSAAP--EEKNGFKPAQEHLDSKARRAHEDLSSSQVGYSEDKQLTESDVIDTTTSREDTS 547

  Fly  1146 -----QERAVINFN----------PNADLDETVRENSVRRLFGKD------------------EA 1177
                 :..|::|..          ..:..:|.....|.:...|::                  |:
  Rat   548 PAYGCKHAAILNSKNTKKVLEVPVKTSQEEEPAASQSQQVSCGEELASERTKIPSASLVQLSKES 612

  Fly  1178 PYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGV 1242
            .:::||...||:||:.||||.|||:||||||:|||..||..|||:..::::.|||||:|.||.|.
  Rat   613 LFLLDASKEGNVGRFLNHSCYPNLWVQNVFVETHDRNFPLAAFFTNRYVKARTELTWDYGYEAGT 677

  Fly  1243 VPGKVLYCQC 1252
            :|.|.:.|||
  Rat   678 MPEKEILCQC 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	24/59 (41%)
		Pre-SET	901..1013	CDD:282838	47/113 (42%)
		SET	1022..1239	CDD:214614	89/320 (28%)
Setdb2	XP_038949803.1	HMT_MBD	152..212	CDD:238689	24/59 (41%)
		SET	210..687	CDD:394802	151/480 (31%)
		SET	365..>425	CDD:395687	23/59 (39%)
		PHD_SF	700..813	CDD:419867
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351968
Domainoid	1	1.000	129	1.000	Domainoid score	I5132
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102569at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46024
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X219
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950