DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eps-15 and TPM1

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_014320.1	Gene:	TPM1 / 855645	SGDID:	S000005023	Length:	199	Species:	Saccharomyces cerevisiae

Alignment Length:	227	Identity:	50/227 - (22%)
Similarity:	102/227 - (44%)	Gaps:	41/227 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   414 EVKPTYSNPELEMIS--KEIEELARERRVLETEIAQKEADVR---IKNGEVRSLQSELDTLTATL 473
            :::...||.:||..|  ::.|||..:.:.||.|..:||..::   :||   :.|:.|::.|.|.|
Yeast     3 KIREKLSNLKLEAESWQEKYEELKEKNKDLEQENVEKENQIKSLTVKN---QQLEDEIEKLEAGL 64

  Fly   474 ---KQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTINEQEGE 535
               ||.|....|.:.::..|..: :|             :..|::.|:..:. .:...::|....
Yeast    65 SDSKQTEQDNVEKENQIKSLTVK-NH-------------QLEEEIEKLEAEL-AESKQLSEDSHH 114

  Fly   536 LNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALL 600
            |.:......| |:::  |:::.:.::.:|.:.|..|:.:.|:...:...|. .||.||:
Yeast   115 LQSNNDNFSK-KNQQ--LEEDLEESDTKLKETTEKLRESDLKADQLERRVA-ALEEQRE------ 169

  Fly   601 ICRAAMENQNAELVSEYQLKIEPDFDEARKTL 632
                ..|.:|.||..:|: ..:.:.||...:|
Yeast   170 ----EWERKNEELTVKYE-DAKKELDEIAASL 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477
		EH	137..202	CDD:238009
		EH	307..402	CDD:197477
		EH	318..384	CDD:238009
		RILP-like	<445..548	CDD:304877	20/108 (19%)
		Spc24	529..>584	CDD:285486	9/54 (17%)
TPM1	NP_014320.1	Tropomyosin_1	7..186	CDD:403808	47/211 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S4078
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950