DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and END3

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:NP_014315.1 Gene:END3 / 855640 SGDID:S000005028 Length:349 Species:Saccharomyces cerevisiae


Alignment Length:441 Identity:94/441 - (21%)
Similarity:161/441 - (36%) Gaps:131/441 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 KYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQT 200
            ||.|:|..|.|....:..::|..:|.:|||..|:|..||.|||.|.|.|||..|||:.|.|::..
Yeast    11 KYWQIFSGLKPIENKVNHDQVLPILYNSKLDSSVLNKIWFLADIDDDDNLDFEEFVICMRLIFDM 75

  Fly   201 LQKR--TIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPA 263
            :.|.  ::|..||..|                      :|           |...|..|:.....
Yeast    76 VNKNISSVPDELPDWL----------------------IP-----------GSKVNLIKERKKRK 107

  Fly   264 AIPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLD 328
            .|.  ...:||...|                          ..||.::|.||.::|:|:......
Yeast   108 QIE--NADLPPKKEI--------------------------KVDWYMSPDDLNQYEKIYNSCAKL 144

  Fly   329 KDGLVSGLEVKDIFIKS--GIPQRSLADIWALCDTNQSGKLTVEQFALAMWFV----ERKQRGVD 387
            .||.::..|:.......  .|.:..|..:|:|.:......:..:.   ..:|:    :|...|.:
Yeast   145 TDGTITFNELSTKLSTKFFNISKTDLNKVWSLINPQNLPSIDRDP---TFYFIHCLRQRNDLGAE 206

  Fly   388 PPHVLNANMVPPSMRATVAGV--------DLQPQEVKPTYSNPELEMISKEIEEL---------- 434
                     :|.|:..::|.|        ||:..: .||....|    :.|::.|          
Yeast   207 ---------IPASLPNSLAEVCNKKQLSYDLRSSQ-PPTKRKEE----ANEVDNLRDNGQNSSSD 257

  Fly   435 ARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRG-EAQKRLDDLQAQVSHNT 498
            :....||..|.:.|:....:.:.:|.:::.:|:.|....|..:.|.| :..||::          
Yeast   258 SSGSNVLSNEDSIKQKYASLTDDQVANMREQLEGLLNYKKSEKTQGGSKLSKRIN---------- 312

  Fly   499 AVLANVSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDE 549
              :.:::.|:....:||..:              |..||.||.|||.|:.|
Yeast   313 --IRSITDDLDNIEQQVEVL--------------ENYLNNKRHELQALQAE 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 32/80 (40%)
EH 137..202 CDD:238009 27/64 (42%)
EH 307..402 CDD:197477 19/100 (19%)
EH 318..384 CDD:238009 11/71 (15%)
RILP-like <445..548 CDD:304877 21/103 (20%)
Spc24 529..>584 CDD:285486 10/21 (48%)
END3NP_014315.1 EF-hand_4 1..104 CDD:289529 37/125 (30%)
EH 123..221 CDD:197477 21/109 (19%)
End3 186..345 CDD:403842 37/201 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I2490
eggNOG 1 0.900 - - E1_KOG0998
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11216
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R396
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.940

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