DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and PAN1

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:NP_012271.3 Gene:PAN1 / 854822 SGDID:S000001445 Length:1480 Species:Saccharomyces cerevisiae


Alignment Length:1435 Identity:278/1435 - (19%)
Similarity:438/1435 - (30%) Gaps:572/1435 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 IDPKGTGAIEAMTAAKF-----LKKSGLSDVVLSRIWDLSDPS--------------GKGF---- 64
            |.|:|||..:|...|..     |:..|..       :.:|.|:              |.|:    
Yeast   143 IQPQGTGYYQAANTANVHSVQPLQSQGTG-------YYVSTPNLISSNQTQQPLQAQGTGYYQSQ 200

  Fly    65 ---LDKPGFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGD 126
               :..|....:|:.:...|.|       .||...|...|..|..|....:.:  .|:.|: |.|
Yeast   201 PQQVPPPQQAQSLQPLKPQQTG-------FYLQPQNQAPLEPLKPTATGFVNS--FANNGL-NND 255

  Fly   127 WSIGVI--------DRLKYEQLFESLHPSNGMLPGNKVKG-----VLMDSKLPMSILGTIWDLAD 178
            ..|..|        |:.|:|.||.|: .:||   .|.|.|     :||.|.||.|.|..||.|.|
Yeast   256 IKIPAIRLSFITAQDQAKFETLFRSI-VTNG---SNTVSGANCRKILMRSGLPPSQLARIWTLCD 316

  Fly   179 QDKDGNLDMHEFVVAMHLVYQTLQKRTIP------------------------------------ 207
            ..|.|.|...||.:||||:...||..|||                                    
Yeast   317 TSKAGELLFPEFALAMHLINDVLQGDTIPYELDSKTKNEVSSFIDAINLSIANQDSSANDAPKTP 381

  Fly   208 ---------------------------------------SVLPPE---------------LRKPG 218
                                                   |.|.|:               ...||
Yeast   382 FDEFITAGVQNLQPQPTGYMPQTSFGIPLQSQITGGGVASALNPQSTGFMAPTTFNMSMNTGTPG 446

  Fly   219 ------GAGP-------------PPKPAMPP------PPAGAAMPRAPSGEGFG----------- 247
                  |..|             |....|.|      |.....||:...|...|           
Yeast   447 LNPQITGGAPASMQPNITGNALQPQTTGMMPQTTGMMPQTTGMMPQTSFGVNLGPQLTGGALQSQ 511

  Fly   248 -DGGFVANFPKDIAPPAAIPPLP------------VAVPPMTRIPPVGAVSSQPL---------- 289
             .||:.:..|:. :.||::|.|.            :...|...:||....::.||          
Yeast   512 YTGGYGSVMPQQ-SGPASMPNLSFNQQGLQSQLTGLQPQPTGFLPPSNFSATMPLTAQKTGFGNN 575

  Fly   290 -IQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLA 353
             |.|...........::.|.:.| .:...|.:||...|....||:......:||.|||:.:..|.
Yeast   576 EIYTKSNFNNNLIDNSSQDKIST-EEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLE 639

  Fly   354 DIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSM----------------- 401
            .||.|||.|.:|:|..::|||.|..|..|..|...|:||.::::|.|.                 
Yeast   640 QIWNLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSLIPSSTKLLDNLKNQLKTEPTTT 704

  Fly   402 --RATVAGVDL-----QPQEVKPTY-----------------SNPELEMISKEIEELARERRVLE 442
              :.:...:|.     ...:|.|.|                 |:|..:.::.....|..:...::
Yeast   705 KEKPSFGKIDALSYKNNDDDVLPNYRNRRKVYSAKNEEQSSFSSPSAKSVNHSSSTLQTDDISVD 769

  Fly   443 TEIAQKEA---------DVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRL-DDLQAQVSHN 497
            ..:.:|.|         ::.:||  :.||::|       :|.:.|........: .||.::....
Yeast   770 KTVEKKTAKPKYAGFSREINLKN--IASLENE-------IKNISNPENCYDSSIPSDLTSRFDAI 825

  Fly   498 TAVLANVSLDISRTNEQVTKIRDQCHMQ-------------EVTINEQE-----GELNAKRSELQ 544
            .|.|.|:..:||..:.::|..:.|.:.:             |:|.|:::     ..|.|:.|.|.
Yeast   826 IAKLPNLFNEISTIDNEITNAKIQLYRKKNPSSIIGSGPNGEITENDRKKAKSRALLRARMSALT 890

  Fly   545 -KLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQ-MTDALLICRAAME 607
             |..:.|.||..|.:..:.|:.::.......|..|..:||.::.:..:.:. ||.:.:|.....|
Yeast   891 GKSTESEDSLSMEDEQQSAEIKRIQQENGKNQEIIKDIRSSISDISASLKSTMTGSNMISNQEFE 955

  Fly   608 NQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKP 672
            ..      |:.:.:|   |..|:.|         |..:.|::.:..:      |.||  .|.:.|
Yeast   956 RW------EFGIGLE---DGVREFL---------DDLKSNSNKSVTE------SSPF--VPSSTP 994

  Fly   673 AISTGFDDSFNMSSGFDSGFDAFGQSGAG-------------SAFGQTQRDPFGSDAFAANKSNA 724
               |..||  ..||...|.|....:..|.             :.|.:.:|:...|....:::::.
Yeast   995 ---TPVDD--RSSSPSYSQFKTAEERAAYLKEQAKKRMKEKLAKFDKNRRNVTQSSRSISSENSR 1054

  Fly   725 ITP----------EPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGP--------PPRPESPSPA 771
            ..|          ||....|..:.:..:..||...|...| .|.:.|        |.:|..|:..
Yeast  1055 EQPQQIAGSSNLVEPRATPFQEEKYVEVAQPTQPVQSTQP-VQPTQPVQPTQPVQPTQPVQPTQP 1118

  Fly   772 LPP------------------------------------KKS----------------------- 777
            :.|                                    ||:                       
Yeast  1119 VQPTQPVQNVYNAKQESDDEDEDDEEKRLQEELKRLKLKKKADKEKRLAALRKQIEDAQNESDEE 1183

  Fly   778 ------------KVPPPRPAPPRAA----------------QPTGGFGSGG-------------- 800
                        .||...|..|.||                .|..|..|.|              
Yeast  1184 ETNGKDNFGGHVNVPQAAPVAPSAAFSQNSTNAPRSVHAAVTPAAGKNSTGLPSTTMGHNPYFKD 1248

  Fly   801 ----------------------------GGGFADFDDFDN-----------KLHH--------IP 818
                                        ..|::|.|:.:|           |:.|        :.
Yeast  1249 ASASSTSTFDARAAEMQRRIQRGLDEDEDDGWSDEDESNNRVAVDNKVEEAKIGHPDHARAPPVT 1313

  Fly   819 SAPSPSATALSPLPPTLP-----------APIPVVSGSSLLDSFTLFDDPGQIHKQAASTPNPTP 872
            :||.||.|   |:||.:|           :|||:   :.:..|.|  .:|          |.|..
Yeast  1314 AAPLPSVT---PVPPAVPVPQANTSNEKSSPIPI---APIPPSVT--QEP----------PVPLA 1360

  Fly   873 ITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITTAPSLNNQHLSRSNTP 937
            ..:|.|....:..:  |:||:.|.| :..|||.:.|.||..||      ..|.|..|..|.|   
Yeast  1361 PPLPAVDGFQEPPI--PSAPAIATA-VQKSGSSTPALAGGVLP------PPPPLPTQQASTS--- 1413

  Fly   938 LQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDYRYEDPFSIKDPFAE 1002
                         :.:::..|.:.  |..|.      ||......|       :|..||.:....
Yeast  1414 -------------EPIIAHVDNYN--GAEKG------TGAYGSDSD-------DDVLSIPESVGT 1450

  Fly  1003 EGEEE 1007
            :.|||
Yeast  1451 DEEEE 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009 15/84 (18%)
EH 126..215 CDD:197477 42/191 (22%)
EH 137..202 CDD:238009 29/69 (42%)
EH 307..402 CDD:197477 34/113 (30%)
EH 318..384 CDD:238009 26/65 (40%)
RILP-like <445..548 CDD:304877 26/131 (20%)
Spc24 529..>584 CDD:285486 14/60 (23%)
PAN1NP_012271.3 DUF1720 144..243 CDD:369766 22/112 (20%)
EH 265..356 CDD:197477 36/94 (38%)
DUF1720 <391..453 CDD:369766 5/61 (8%)
DUF1720 459..553 CDD:369766 16/94 (17%)
EH 595..688 CDD:197477 33/93 (35%)
MARTX_Nterm <884..1033 CDD:380155 37/179 (21%)
Amelogenin <1056..1125 CDD:397207 14/69 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I2639
eggNOG 1 0.900 - - E1_KOG0998
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11216
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.910

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