Protein Alignment Eps-15 and REPS1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: NP_001273540.1
• Gene: REPS1 / 85021
• HGNCID: 15578
• Length: 796
• Species: Homo sapiens
• Alignment Length: 1042
• Identity: 206/1042 - (19%)
• Similarity: 302/1042 - (28%)
• Gaps: 433/1042 - (41%)

  Fly    46 SDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPS 110
            :|||| :|.:|...:..|:..:..|::|||||:::|:|....:.:|     |..|...||:.:.|
Human    46 NDVVL-QIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESI-----NTVKDLPLPRFVAS 104

  Fly   111 RIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPS------------NGMLPGNKVKGVLMDS 163
                                     |.||  ||.|.:            :|::|....:|
Human   105 -------------------------KNEQ--ESRHAASYSSDSENQGSYSGVIPPPPGRG----- 137

  Fly   164 KLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRT------------IPSVLPP---- 212
                           |.|.|::.           :.|:|.||            .|...||
Human   138 ---------------QVKKGSVS-----------HDTVQPRTSADAQEPASPVVSPQQSPPTSPH 176

  Fly   213 ----ELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPP-------AAIP 266
                ..|.|.| |...:|...|.|..:....|.||...||..:..:.|   .||       |..|
Human   177 TWRKHSRHPSG-GNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSP---PPPQENWVSFADTP 237

  Fly   267 PL-------PVAVPPMTRIPPVGAVSS------QPLIQTDPLIPIGAPVMANADWVVTPADLKRF 318
            |.       |.:|...|.:..|.:.::      |.....||             |.:|....:.:
Human   238 PTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDP-------------WKITDEQRQYY 289

  Fly   319 EEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQ 383
            ...|:....|.:|.:.|...|:.|.||.:|...|:.||.|.|.::.|.||:::|..|...|..::
Human   290 VNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARK 354

  Fly   384 RGVDPPHVLNANMVPPSM-RATVAGVDLQPQEV--------KPTYSNPELEMISKEIEELARERR 439
            .|.|.|..|..:::|..: ....|.|..||.||        .|...:|.:..:::...||.:...
Human   355 NGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSE 419

  Fly   440 VLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANV 504
            ..||                   .||..:.:.||.|.::....|..           :||::..|
Human   420 QWET-------------------FSERSSSSQTLTQFDSNIAPADP-----------DTAIVHPV 454

  Fly   505 SLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTN 569
            .:.::.:         :.||||:.:         ||:.                         ::
Human   455 PIRMTPS---------KIHMQEMEL---------KRTG-------------------------SD 476

  Fly   570 HLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTK 634
            |...|.                                          .|.::|
Human   477 HTNPTS------------------------------------------PLLVKP----------- 488

  Fly   635 EVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSG 699
                  .|..|||                                 ..|.|..|
Human   489 ------SDLLEEN---------------------------------KINSSVKF----------- 503

  Fly   700 AGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPR 764
               |.|.|..|.:.|                .|.|.|||.......|.|......:...:.|||.
Human   504 ---ASGNTVADGYSS----------------SDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPP 549

  Fly   765 PESPSP--------------------------ALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGG- 802
            |..|.|                          |.||    ..||||.|.:|..|.........|
Human   550 PPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPP----AVPPRPQPSQAPGPAVHRPVDADGL 610

  Fly   803 ---------------GFADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFT 852
                           .||||..|:  :....:............|..|||.......|||..:.|
Human   611 ITHTSTSPQQIPEQPNFADFSQFE--VFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKT 673

  Fly   853 LFDDPGQIHKQAASTP-----NPTPITVPTVHTLLQTSLSTPAAPSPALASLS------------ 900
               |.....|.|||.|     ..||:..|               |.|....|.
Human   674 ---DSKTEEKTAASAPANVSKGTTPLAPP---------------PKPVRRRLKSEDELRPEVDEH 720

  Fly   901 TSGSGSVAGAGADLPS---SV-----TITTAPSLN---NQHLSRSNTPLQNQRTADVKLETKAVV 954
            |..:|.:|...|..||   ||     .|..:...|   |..|:|.|:.|| |:..|| ||.:..:
Human   721 TQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQ-QQLKDV-LEERISL 783

  Fly   955 SV 956
            .|
Human   784 EV 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	13/35 (37%)
		EH	126..215	CDD:197477	19/120 (16%)
		EH	307..402	CDD:197477	27/95 (28%)
		SMC_prok_B	<423..>632	CDD:274008	23/208 (11%)
REPS1	NP_001273540.1	EH	6..85	CDD:197477	15/39 (38%)
		PRK07764	<97..228	CDD:236090	37/192 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..237		35/168 (21%)
		EH	278..369	CDD:197477	27/103 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..433		14/74 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..624		28/137 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..725		21/104 (20%)
		Interaction with RALBP1. /evidence=ECO:0000250	652..796		42/154 (27%)