DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and AT1G21630

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_001185056.1	Gene:	AT1G21630 / 838765	AraportID:	AT1G21630	Length:	1247	Species:	Arabidopsis thaliana

Alignment Length:	1467	Identity:	284/1467 - (19%)
Similarity:	496/1467 - (33%)	Gaps:	521/1467 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            :::.|::..|..|.|.|....|..|.:.|.|...||:::|..:|....|:|.:..|:.|||||::
plant    12 LFDTYFRRADLDGDGHISGAEAVAFFQGSNLPKHVLAQVWSYADSKKAGYLGRAEFYNALKLVTV 76

  Fly    80 SQAGQVASMANIYLDIANP-------PKL-----------GELPKTMPSRIQTVPVASGGVANGD 126
            :|:.:..:...:...|.:|       ||:           |.||.|....:.::|..:.|| .|.
plant    77 AQSRRELTAEIVKAAIYSPASANIPAPKINLAATPSPQPRGVLPATQAQGVTSMPSVAAGV-RGP 140

  Fly   127 WSIGVIDR------------------LKYEQLFES----------LHPSNGMLPGNKVKGVL--- 160
            ...|.:..                  .:.:|.|:|          ..|:|..:|.:.:.|..
plant   141 HMGGTVSTSNQQVVPGQQNQFTGIPPSQTQQNFQSPGMPAGGTNAPRPANQPMPSDWLSGRSVGP 205

  Fly   161 ---MDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPGGAGP 222
               ::|::|.|  .:.:.|...:...|     .:...|:.         |:|......:|..:.|
plant   206 SGNVNSQIPSS--QSTYGLTAPNSTAN-----HITKPHIT---------PAVTSSTTTRPQESAP 254

  Fly   223 PPKP---------AMPPPPAGAAMPRAP-----SGEG------FGDGGFVAN-----FPKDIAPP 262
            ...|         .:...|:...:|:.|     ||.|      |||...|.:     .|...|..
plant   255 VHNPQESSATFGSRVSNVPSNQLVPKDPKELAASGNGFTSDSLFGDVFSVTSTQPKQHPTGSAST 319

  Fly   263 AAIPPL---PVAVPPMTR-------IPPVGAVSSQPL-IQTD------------------PLIPI 298
            ..|..:   .||.|.:|:       ||..|::|...: :||.                  |...:
plant   320 TGISSVTTGTVAGPEITQSVVRQSSIPQQGSLSQHAVGVQTQLTGNSGQPYTSSGAASGPPGSTV 384

  Fly   299 GAPVMANAD-----------------------W-VVTPADLKRFEEIFRQSDLDKDGLVSGLEVK 339
            |..:.|.:.                       | .:||||::::.::|.|.|.|:||.::|.:.:
plant   385 GVGISATSQLAQRPPHPHSQPQPRPQGQSQPPWPKMTPADVQKYTKVFVQVDTDRDGKITGNQAR 449

  Fly   340 DIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRAT 404
            ::|:...:|:.:|..:|.|.|.:....|::.:|.:|::.:||.:.|...|.|..::::......|
plant   450 NLFLSWRLPRDALKQVWDLSDQDNDSMLSLREFCIAVYLMERYREGRPLPPVFPSSIIHSESMFT 514

  Fly   405 VAG---------------------------------------VDLQPQE--VKPTYSNPELEMIS 428
            ..|                                       |.|.|.:  |:||....::.::.
plant   515 SPGQSVAPHGNASWGHPQGFQQQPHPGGLRPPAGPKGKPPRPVPLSPSDGMVQPTQPKRKMPVLE 579

  Fly   429 KE-IEELARERR-VLETEIAQKEA---------------------DVRIK------------NGE 458
            |. :::|::|.: .|.|:..:..|                     .:.:|            ..|
plant   580 KPLVDQLSKEEQDSLNTKFEEATAVDKKFSFFAFSIRRYLLPLPYGIYMKYLWICVAIVDELEKE 644

  Fly   459 VRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCH 523
            :...:.::|...|.:::|...:.....|.:::..:|..:...|.:::.......::...:..:..
plant   645 IADSKQKIDFFRAKMQELVLYKSRCDNRYNEIAERVLGDKRELESLAKKYEEKYKKSGNVGSKLT 709

  Fly   524 MQEVTINEQEGELNAKRSELQK--LKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVT 586
            ::|.|..    ::..|:.||.:  :|.||..|.   ||    :.|.|.|:|      |.:..::.
plant   710 IEEATFR----DIQEKKMELYQAIVKFEEGKLD---DS----IVKRTEHIQ------SGLEELIK 757

  Fly   587 QLLETQRQMTDALLICRAAMENQNAELV----------SEYQLKIEPDFDEAR-------KTLTK 634
            .|.|..:|.         .:..:...||          .|.....:.|:|:..       |.||.
plant   758 NLNERCKQY---------GVRGKPTSLVELPFGWQPGIQEGAADWDEDWDKLEDEGFTFVKELTL 813

  Fly   635 EVQLPKDDPFEENN--------SGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSG 691
            ::|.....|.|:::        |....:..:...:|..:|:..     |:|.:|| ..|.|..|.
plant   814 DIQNVIAPPKEKSSAWRKEVDVSSKEGEDVSFSDADSKTGKKQ-----SSGEEDS-EQSEGKTSD 872

  Fly   692 FDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAA------LHAPTGQGQ 750
            .||..::  ||......|.  |.:|.::.::.....|.|.||..|...|.      .|..|....
plant   873 VDARDKN--GSLDDSKVRK--GIEADSSPRTKDTRSENGHDDGESTASAGKTVNYDSHDETDSVS 933

  Fly   751 VLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGGFADFDDFDNK-- 813
            .::|:..|.                               :..|.:.||.|.||. ||||..|
plant   934 SVNPDNGKD-------------------------------KDHGKYDSGFGFGFG-FDDFSIKPI 966

  Fly   814 -------LHHIP--------SAPSPSATA--LSPLPPTLPA----PIPVVSGSSLLDSFTLFDDP 857
                   ...:|        |.|||.|.|  :||..|:|.|    ..|..:.:|.....:.|||
plant   967 KTGSTISNDFLPPKLSIFADSVPSPPANASDVSPTKPSLFADSVPSTPATNNASYPGQKSFFDD- 1030

  Fly   858 GQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITT 922
                            :||          ||||.|....|...:....||
plant  1031 ----------------SVP----------STPAYPGNLFAEKKSFFDDSV--------------- 1054

  Fly   923 APSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAP-TPSLITGPTDFKDDPF- 985
             ||          ||..   ..::..|.|   |.||       ...| ||:..|  :||...||
plant  1055 -PS----------TPAY---PGNLFAEKK---SYFD-------DSVPSTPAYST--SDFGGKPFA 1093

  Fly   986 -KDYRYEDPFSIKDPFAEEGEEELSEGKGADHKRNFAEDFSSGDEIGSAAKTLSNIVNNNSIKPK 1049
             :..|.::.|..:.||                         ..|.:.|.              |.
plant  1094 SETPRSDNLFPGRSPF-------------------------MFDSVPST--------------PA 1119

  Fly  1050 AATPLNNDLLQQFDAFNLNSSPAPSHHSGTSYHSNSKPSHDSQTALDAFAD-FDDFAATLATTGG 1113
            |....:|:...:||:||.|::.|.|.....|..|.|:|        |.||. ||.|
plant  1120 AHDDFSNNSFSRFDSFNSNNNDAFSLSRTDSMRSTSEP--------DPFASRFDSF--------- 1167

  Fly  1114 SGAATTATTTGNTKLNNSFFDAFNDNFSVIQSSSVPTGVVRPNDQRAKAFDAFNDNFEDQFKTSP 1178
                           |...:|:||                      |:::|:.::|...:   :|
plant  1168 ---------------NYQRYDSFN----------------------AQSYDSSSNNNASE---TP 1192

  Fly  1179 NANFAKFDGFEA---HNFSSDFG---NASFGTTGKEK 1209
            .|:..:||...:   .::|..||   :..||:||..|
plant  1193 KASLTRFDSIGSTRDSDYSHGFGFDDHDPFGSTGPFK 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	21/65 (32%)
		EH	126..215	CDD:197477	16/122 (13%)
		EH	137..202	CDD:238009	13/80 (16%)
		EH	307..402	CDD:197477	26/118 (22%)
		EH	318..384	CDD:238009	18/65 (28%)
		RILP-like	<445..548	CDD:304877	14/137 (10%)
		Spc24	529..>584	CDD:285486	14/56 (25%)
AT1G21630	NP_001185056.1	EH	13..79	CDD:238009	21/65 (32%)
		EF-hand_7	17..71	CDD:290234	15/53 (28%)
		TFIIA	95..>263	CDD:281188	30/184 (16%)
		EH	416..509	CDD:197477	26/92 (28%)
		EH	428..494	CDD:238009	18/65 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I1636
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1020
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050