DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and AT1G20760

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_173499.1	Gene:	AT1G20760 / 838666	AraportID:	AT1G20760	Length:	1019	Species:	Arabidopsis thaliana

Alignment Length:	1229	Identity:	257/1229 - (20%)
Similarity:	411/1229 - (33%)	Gaps:	444/1229 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLS 80
            :|||:|..|..|.|.|....|..|.:.||||..||::||.|||.|..||||:..|:.:|:||:::
plant    11 FEAYFKRADLDGDGRISGAEAVGFFQGSGLSKQVLAQIWSLSDRSHSGFLDRQNFYNSLRLVTVA 75

  Fly    81 QAGQVASMANIYLDIAN------------PPK--LGELPKTMPSRIQTV--PVASGGVANGDWSI 129
            |     |..::..:|.|            |||  |..:|...|:...|.  ||:..|   |..:.
plant    76 Q-----SKRDLTPEIVNAALNTPAAAKIPPPKINLSAIPAPRPNPAATTVGPVSGFG---GPGAP 132

  Fly   130 GVIDRLKY--EQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVV 192
            ..|....|  .|..:.:.|:.|:.....::........|.::.|
plant   133 NAIVNQNYFPPQQNQQMRPNQGISGLTSLRPAAGPEYRPSALSG--------------------- 176

  Fly   193 AMHLVYQTLQKRTIP--SVLPPELRKPGGAGPPPKPAMPPPP-----------AGAAMPRAPSGE 244
                     |.:.:|  ||..|         |.|.|.....|           |||......| .
plant   177 ---------QFQPVPVGSVTHP---------PQPVPTSVSGPGSSTFNLNSLYAGAGNTSGYS-S 222

  Fly   245 GFGDGGFVANFP-----KDIAPPA-----------------------------AIPPLPVAVPPM 275
            |||.|...|..|     ..|.|.|                             ||.|....:.|.
plant   223 GFGGGSLAAPSPGLKQESHIDPKALVVSGNGGDMFSSFQQKQEPTLSNSSISSAIVPTSAGIQPP 287

  Fly   276 TR-------------IP-------PVGAVSSQPLIQTD-PL--IPIGAPVMA---------NADW 308
            |:             :|       |..|.||||.:.:. |.  :|.|:.|.:         ...|
plant   288 TKPNALDSLQSTFSMLPSGNQLQQPRPAASSQPAVSSQGPSSGLPPGSAVGSGHSTPAGNNQPPW 352

  Fly   309 -VVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQF 372
             .:.|:|::::.::|.:.|.||||.::|.:.:::|:...:|:..|..:|.|.|.:....|::.:|
plant   353 PKMKPSDVQKYTKVFMEVDSDKDGKITGEQARNLFLSWRLPREVLKHVWELSDQDNDTMLSLREF 417

  Fly   373 ALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVD----------------LQP----QEVKP 417
            .::::.:||.:.|...|..|.::::......:::|..                .||    :.:.|
plant   418 CISLYLMERYREGRPLPTALPSSIMFDETLLSISGAPSHGYANAGWGSGQGFVQQPGMGARPITP 482

  Fly   418 TYS-NPELEMISKE------IEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQ 475
            |.. .|.:.....:      ..:...:..||:...|.     .:.||  .|..|.|....|.
plant   483 TTGMRPPVPAPGPQPGSGIPPNQPRNQAPVLDAPFAN-----HLGNG--YSASSNLPEAAAD--- 537

  Fly   476 LENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKR 540
             |.:..|.|....|.:.::.:....:.::.|..||.:.::.:|.::     .:.:::|.|..||:
plant   538 -EEKVDEKQNAYMDSREKLDYYRTKMQDIVLYKSRCDNRLNEISER-----ASADKREAETLAKK 596

  Fly   541 SELQ---------KLKDEEASLQKEYDSNNRELSKLTNHLQ-------ATQLQISSVRSMVTQLL 589
            .|.:         ||..|||.. :|.:....|||:...:::       ..|::...::|.:.:|:
plant   597 YEEKYKQVAEIGSKLTIEEARF-REIEGRKMELSQAIVNMEQGGSADGLLQVRADRIQSDLEELM 660

  Fly   590 E--TQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPF-------- 644
            :  |:|        |:......|::.:.:.....:|...|......:|....:|:.|
plant   661 KALTER--------CKKHGLEVNSKALVDLPAGWQPGIQEGAALWDEEWDKFEDEGFGNEITFDK 717

  Fly   645 --EENNSGAANQATNGFGS-------------DPFS----------------------GQPVNK- 671
              |:|:||.....|...||             .|||                      ..||::
plant   718 SKEQNSSGEKENGTVDDGSGPPDSPTHVEDNYGPFSETSDRHHESEYGTTHSEDRSPRDSPVSRN 782

  Fly   672 ------PAISTG-----FDDSFNMSSGFDS--------GFDAF-GQSGAGSAFGQTQRDPFGSDA 716
                  |..|.|     |||| |.:|.||:        ||||. .|.|          |.|||.
plant   783 ATEVPSPDYSQGKNSEFFDDS-NWASAFDTNDDVDSVWGFDASKSQDG----------DYFGSG- 835

  Fly   717 FAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPP 781
                           ||||                        |...|.:|||
plant   836 ---------------DDFG------------------------GNTARADSPS------------ 849

  Fly   782 PRPAPPRAAQPTGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSS 846
                       :..||:.....|| |||         |.||...:.....||..       |.:|
plant   850 -----------SRSFGAQRKSQFA-FDD---------SVPSTPLSRFGNSPPRF-------SDAS 886

  Fly   847 L----LDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSV 907
            .    .|||:.||                                          |.:|    |.
plant   887 ARDNNFDSFSRFD------------------------------------------SFNT----SE 905

  Fly   908 AGAG-ADLPSSV----TITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRK 967
            |||| :..|..:    :|.::........||.:: :.:.|  ||....|     |..|..|.:.|
plant   906 AGAGFSSQPERLSRFDSINSSKDFGGAAFSRFDS-INSSR--DVTGAEK-----FSRFDSINSSK 962

  Fly   968 -APTPSL-----ITGPTDFKDDPFKDYRYEDPFSIKDPFAEEGEEELSEGKGADHKRNF 1020
             ...|||     :....||.......:...|||....||....:|  |..|.:|:..:|
plant   963 DFGGPSLSRFDSMNSTKDFSGSHGYSFDDADPFGSTGPFKVSSDE--SPTKRSDNWNSF 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	30/65 (46%)
		EH	126..215	CDD:197477	12/92 (13%)
		EH	137..202	CDD:238009	6/66 (9%)
		EH	307..402	CDD:197477	23/95 (24%)
		EH	318..384	CDD:238009	17/65 (26%)
		RILP-like	<445..548	CDD:304877	22/111 (20%)
		Spc24	529..>584	CDD:285486	15/70 (21%)
AT1G20760	NP_173499.1	EH	11..77	CDD:238009	31/70 (44%)
		EH	351..441	CDD:197477	23/89 (26%)
		EH	363..429	CDD:238009	17/65 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I1636
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1020
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050