DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and ITSN1

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_003015.2	Gene:	ITSN1 / 6453	HGNCID:	6183	Length:	1721	Species:	Homo sapiens

Alignment Length:	1105	Identity:	251/1105 - (22%)
Similarity:	405/1105 - (36%)	Gaps:	317/1105 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQD 180
            |...||..: .|:|.|.:|.|::|.|.||.|.:|.:.|::.:.....|.||..:|..||.|||.:
Human     5 PTPFGGSLD-IWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMN 68

  Fly   181 KDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP------------GG-AGPPPKPAMPPPP 232
            .||.:|..||.:||.|:...||...:||.|||.:::.            || |..||..|:.|.|
Human    69 NDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVP 133

  Fly   233 AGA--AMPRAPSGEGFGDGGFVANFPKDIAPPAA------IPPLPVAVPPMTRIPPVGAVS-SQP 288
            .|:  .:..:|:        .|::.|....||.|      |.|||....|...:|...:.| |.|
Human   134 MGSIPVVGMSPT--------LVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190

  Fly   289 LIQTDPLIPIG-----APVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIP 348
            ..|.:..:...     |.|...|:|.|..:...::.::|...|....|.::|.:.:.|.::|.:|
Human   191 GSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLP 255

  Fly   349 QRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAG------ 407
            |..||.||.|.|.:|.||||.|:|.|||..::....|...|.||....:|||.|...:|
Human   256 QAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVI 320

  Fly   408 ----VDLQ-PQE-------------VKPTYSNPELEMISKEIEELARER------------RVLE 442
                ||.: |:|             :..|:.:.:.|...:...||.:.|            |:.:
Human   321 SSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385

  Fly   443 TEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLD 507
            .|.|::|...|.:..:.|..|.||:      ||||.||...::|.::.:.::....|.
Human   386 LERAEQERKERERQEQERKRQLELE------KQLEKQRELERQREEERRKEIERREAA------- 437

  Fly   508 ISRTNEQVTKIRDQCHMQEVTINEQEGE------LNAKRS----ELQKLKDEEASLQKEYDSNNR 562
             .|..|:..::..:.:.::..:|::..|      |.||:.    ||:.|.|::..|:.:......
Human   438 -KRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRC 501

  Fly   563 ELSKLTNHLQAT----QLQISSVRSMVTQLLETQRQM-----------------------TDALL 600
            .|:.....:::|    :|:|:.:..:..||.|:|:.:                       .|:|:
Human   502 RLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLV 566

  Fly   601 ICRAAME----------NQNAELVSEYQLKIEP------DFDEARKTLTKEVQLPKDDPFE---- 645
            ..:.|:|          :|..|:..|.:.|::.      ...|.|:...|: ||.|....|
Human   567 TLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ-QLQKQKSMEAERL 630

  Fly   646 ----------------ENNSGAANQATNGFGSDPFSGQPVNKP-----AISTGFDDSFNMSSGFD 689
                            |.....|.:....:...........:|     ......::|.....|.:
Human   631 KQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695

  Fly   690 SGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAP--TGQGQVL 752
            .|... .|...|..|.|.|                   ||.|        .|:.||  |.:...|
Human   696 KGKQE-AQDKLGRLFHQHQ-------------------EPAK--------PAVQAPWSTAEKGPL 732

  Fly   753 SPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPP--------------RAAQP--TGGFGSGGG 801
            :.:||::.......    ||.|.:|:........|              :..:|  .||...|..
Human   733 TISAQENVKVVYYR----ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT 793

  Fly   802 GGFADFDDFDNKL--HHIPSAPSPSATALSPLPPTL-----PAPIPVVSGSSLLDSFTLFDDPGQ 859
            |.|.  .::..|:  :.:|:...|...:.|...|.|     |||:.|.|
Human   794 GWFP--ANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS---------------- 840

  Fly   860 IHKQAASTPN---------PT------------------PITVPTVHTLLQTSLSTPA-----AP 892
              .:.::|||         ||                  .:|||:...|.|.|..|||     :|
Human   841 --SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903

  Fly   893 SPALASLSTSGSG-SVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSV 956
            ||.|      |.| .|.|..|                    ::..|.:.::...:......|::|
Human   904 SPVL------GQGEKVEGLQA--------------------QALYPWRAKKDNHLNFNKNDVITV 942

  Fly   957 FDA-----FGEIGTRKAPTP----SLITGPTDFKDDPFKDYRYEDPFSIK---DPFAE---EGEE 1006
            .:.     |||:..:|...|    .||:||.. |.........|.|.|:|   .|.|:   .|||
Human   943 LEQQDMWWFGEVQGQKGWFPKSYVKLISGPIR-KSTSMDSGSSESPASLKRVASPAAKPVVSGEE 1006

Fly 1007 1006
Human 1007 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	36/88 (41%)
		EH	137..202	CDD:238009	24/64 (38%)
		EH	307..402	CDD:197477	33/94 (35%)
		EH	318..384	CDD:238009	24/65 (37%)
		RILP-like	<445..548	CDD:304877	25/112 (22%)
		Spc24	529..>584	CDD:285486	14/68 (21%)
ITSN1	NP_003015.2	EH	14..108	CDD:197477	36/93 (39%)
		EH	26..90	CDD:238009	24/63 (38%)
		EH	214..309	CDD:197477	33/94 (35%)
		EH	225..291	CDD:238009	24/65 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..348		4/25 (16%)
		KLERQ	326..702		66/391 (17%)
		GBP_C	<331..414	CDD:303769	17/88 (19%)
		COG1340	372..686	CDD:224259	55/328 (17%)
		coiled coil	383..394	CDD:293879	3/10 (30%)
		coiled coil	403..414	CDD:293879	6/16 (38%)
		AAA_23	<509..636	CDD:290211	22/127 (17%)
		GBP_C	<616..686	CDD:303769	8/70 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..701		5/51 (10%)
		SH3_Intersectin1_1	744..803	CDD:212920	11/64 (17%)
		INTAP	803..917	CDD:293223	33/137 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..868		7/49 (14%)
		SH3_Intersectin1_2	917..968	CDD:212922	9/70 (13%)
		SH3_Intersectin1_3	1006..1057	CDD:212924	1/1 (100%)
		SH3_Intersectin1_4	1074..1138	CDD:212926
		Required for interaction with FCHSD2. /evidence=ECO:0000269\|PubMed:29887380	1074..1138
		Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269\|PubMed:29599122	1104..1127
		SH3_Intersectin1_5	1158..1211	CDD:212928
		RhoGEF	1242..1422	CDD:279015
		PH_ITSN	1448..1579	CDD:270084
		PH	1465..1571	CDD:278594
		C2_Intersectin	1582..1716	CDD:176021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840