DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and eps15l1a

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	XP_009294589.1	Gene:	eps15l1a / 568170	ZFINID:	ZDB-GENE-060503-274	Length:	943	Species:	Danio rerio

Alignment Length:	952	Identity:	307/952 - (32%)
Similarity:	448/952 - (47%)	Gaps:	225/952 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            |||.:|:.:||..||.:....||.|||||||.|:.|.:||||:||.|||||||.||:|||:||:.
Zfish    16 VYENFYRQVDPGNTGRVGPTEAALFLKKSGLPDITLGKIWDLADPDGKGFLDKQGFYVALRLVAC 80

  Fly    80 SQAGQVASMANIYLDIANP-------PKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKY 137
            :|:|...|::::.|.:..|       |.|..:..|..|.               |::...::.|:
Zfish    81 AQSGHDISISSLNLPVPPPKFKDHSSPSLSSVTSTNESH---------------WAVRPEEKSKF 130

  Fly   138 EQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQ 202
            :.:||||.|.||:|.|.|||.||::||||:.:||.:|||:|.||||:||..||.|||||||:.|:
Zfish   131 DGIFESLAPVNGLLSGEKVKPVLINSKLPVDVLGKVWDLSDIDKDGHLDRDEFAVAMHLVYRALE 195

  Fly   203 KRTIPSVL-----PPELRKPGGAG----PPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKD 258
            |..:||||     ||..||.....    .|..|..||||..:.......|.
Zfish   196 KEPVPSVLPSSLIPPSKRKKSSGSLSSMVPVLPGSPPPPKDSLRSTPSHGS-------------- 246

  Fly   259 IAPPAAIPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFR 323
                            |..:...|::|.:..:::.         ..:.:|||..||..|:::||.
Zfish   247 ----------------MNSLNSAGSLSPKHTLKSS---------QHSVNWVVPVADRGRYDDIFL 286

  Fly   324 QSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVD 387
            ::|.|.||.||||||||||::||:.|..||.||||.||.|.||||.|||:|||:.:::| .:|:|
Zfish   287 KTDSDLDGFVSGLEVKDIFMQSGLHQNLLAHIWALADTRQMGKLTREQFSLAMYLIQQKVSKGLD 351

  Fly   388 PPHVLNANMVPPSMRATVAGVDLQPQEVKPTYSNP------------------------------ 422
            ||..|..:|:|||.|.|       |......|..|
Zfish   352 PPQALTPDMIPPSERGT-------PGPSLSGYMTPVGSDMAALTEMRRAIMFKLWDSSSSVGSGE 409

  Fly   423 -----ELEMISKEIEEL-----------ARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTA 471
                 ||:.||:||.:|           .||:..||.:|.:.|..:|.|..||:.:|::||..|:
Zfish   410 FTGIKELDDISQEIAQLQSTLAFTHWDTLREKYTLEQDIRETEEAIRHKTTEVQEMQNDLDRETS 474

  Fly   472 TLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTINEQEGEL 536
            :|::||.|:.:||.||:::..|.:....:|.:|.......::.::.::.|.|.||..:..||.||
Zfish   475 SLQELEAQKQDAQDRLEEMDQQKAKLEDMLNDVRQKCQEESQMISSLQTQIHSQESDLQSQEEEL 539

  Fly   537 NAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQ------- 594
            ...:::|.:|:.|||.|::...:...:|..:...|:|||.:|:..||.::|:.::|.:
Zfish   540 GRAKADLNRLQQEEAQLEQSLQAGRIQLETIIKSLKATQDEINQARSKLSQIQDSQHEISKNIEQ 604

  Fly   595 ------------MTDALLICRAAMENQNAEL-VSEYQLKIEPD-FDEARKTL-TKEVQLP---KD 641
                        ||:...:.....|.:|... ..|...|::|. |:.|.:.: |...|..   |.
Zfish   605 YSSTLNGTHGGSMTNLADMSEGFPEKENGGFGAMEDPFKVKPTVFNSAPQEMHTDPFQSEDPFKT 669

  Fly   642 DPFEENNSGAANQATNGF---GSDPFSGQPVNKPAIST----GFD-----DSFNMSSGFDSGFDA 694
            |||:|      .:.:|.|   |.|||...|.:|||.:.    |.|     |.|..||.     |.
Zfish   670 DPFKE------ERLSNRFVKSGGDPFQNDPFSKPATTVPDPFGGDPFKETDPFRTSSE-----DF 723

  Fly   695 FGQSGAGSAFGQTQRDPFGSDAFAANKSN---------AITPEP-GKDDFGS-DPFA-------- 740
            |.:......|  |..|||...|...:||:         :.:|:| |:|.||: |||.
Zfish   724 FKKPSKPDPF--TNADPFSKSATLPSKSHHFASNDPFISTSPKPKGQDFFGTLDPFGSSTFGSNS 786

  Fly   741 --ALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRA-AQPTGGFGSGGGG 802
              |..:...:|.|..|.::|        ...||||||||  .||||.||.. :.|....|||...
Zfish   787 GFADFSQMSKGFVEDPFSRK--------QDMPALPPKKS--IPPRPKPPSGKSTPVNVPGSGDPA 841

  Fly   803 GFAD-------------------FDDFDNKLHHIPSAPSPSA 825
            ..:|                   .|.|..|....|||||.::
Zfish   842 KTSDPFQPFSADPVDPFQCKKGVGDPFSGKDPFAPSAPSKAS 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	38/65 (58%)
		EH	126..215	CDD:197477	49/93 (53%)
		EH	137..202	CDD:238009	39/64 (61%)
		EH	307..402	CDD:197477	54/95 (57%)
		EH	318..384	CDD:238009	39/66 (59%)
		RILP-like	<445..548	CDD:304877	31/102 (30%)
		Spc24	529..>584	CDD:285486	17/54 (31%)
eps15l1a	XP_009294589.1	EF-hand_4	11..101	CDD:332633	44/84 (52%)
		EH	120..213	CDD:197477	49/92 (53%)
		EH	270..366	CDD:197477	54/95 (57%)
		SMC_N	414..>610	CDD:330553	56/195 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31881
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360276at33208
OrthoFinder	1	1.000	-	-		FOG0001628
OrthoInspector	1	1.000	-	-		otm24764
orthoMCL	1	0.900	-	-		OOG6_101578
Panther	1	1.100	-	-	O	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R396
SonicParanoid	1	1.000	-	-		X924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.090