DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eps-15 and itsn2a

DIOPT Version :10

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:XP_021324162.1 Gene:itsn2a / 566412 ZFINID:ZDB-GENE-041014-84 Length:1666 Species:Danio rerio


Alignment Length:594 Identity:149/594 - (25%)
Similarity:255/594 - (42%) Gaps:138/594 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 NGDWSIGVI---DRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNL 185
            ||.:||..|   :|.|:::.|:||.|:.|.|.|::.:...:.|.||.|:|..||.|||..|||.:
Zfish     2 NGGFSIWAITPEERGKHDKQFDSLAPTLGYLSGDQARKFFLQSGLPTSVLADIWALADIGKDGKM 66

  Fly   186 DMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP-----------GGAGPPPKPAMPPPPAGAAMPR 239
            |..||.:||.|:...||.:.:||.||..:::.           |....|...||...|....:|.
Zfish    67 DRLEFSIAMKLIKLQLQGQPLPSSLPIIMKQTPTPVMTSSSRFGMGSMPNLSAMSVMPILTPIPT 131

  Fly   240 APSGEGFGDGGFVANFPKDIAPPAAIP-----PLP-----VAVPPM-----TRIPPVGAVS-SQP 288
            .|.                :||...:|     |||     ::||.:     |.:.|..|.. |..
Zfish   132 CPV----------------MAPLVPVPTLISGPLPQMPNSISVPALPNGNATLLTPTPAFPVSSG 180

  Fly   289 LIQTDPLIPIG---------------APVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEV 338
            |.::..|:.:|               :|..:::||.|..:...::.::|...|....|.:||.:|
Zfish   181 LTKSHSLLDLGSSSSNSSSTTSLASNSPKTSSSDWAVPQSSRLKYRQLFNSLDKLMSGYLSGPQV 245

  Fly   339 KDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRA 403
            ::....|.:.|..||.||.|.|.::.|:|..|:|.|||..||..:.|...|..|..::||||:| 
Zfish   246 RNALTASNLTQTQLATIWFLADVDRDGQLRAEEFILAMHLVEMAKTGRPLPLTLPPDLVPPSLR- 309

  Fly   404 TVAGVDL----------------QPQEVKP--TYSNPELEMISKEIEELARERRVLETEIAQKEA 450
            |....||                .||:.|.  :|.:...|...:...||.:.|..|:.:  |:..
Zfish   310 TTKSCDLLNGPVPLISTELIEPELPQKNKSNVSYEDKLRENFQRGNAELEKRRLALQEQ--QRRE 372

  Fly   451 DVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQV 515
            :.|.:..|.|..:          |:.:.:|.|.::|  :.:|:           .::|.|..|:.
Zfish   373 EERRREEERREEE----------KRQQKEREERERR--EREAR-----------EMEIRRQREEE 414

  Fly   516 TKIRDQCHMQEVTINEQEGEL-------NAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQA 573
            .::..|..::.....|:..||       ..:|.|.:|.|..|...|||.:.|  ::.:|.:..::
Zfish   415 RRMERQRELERQREEERLKELERREEAERQRRREWEKSKRVELQTQKEKEQN--DIQRLKDRKRS 477

  Fly   574 TQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAEL-------------VSEYQLKIEPDF 625
            .::::.:|.:...|:   ..|:.||    ::..:.|.|||             ::..||:    |
Zfish   478 LEIELEAVGNKHKQI---SSQLRDA----KSKRQGQWAELELINQRRDVCITDINSLQLQ----F 531

  Fly   626 DEARKTLTK 634
            ||.::.|.:
Zfish   532 DEMQRQLNQ 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 37/91 (41%)
EH 307..402 CDD:197477 33/94 (35%)
SMC_prok_B <423..>632 CDD:274008 45/228 (20%)
itsn2aXP_021324162.1 EH 7..92 CDD:197477 34/84 (40%)
EH 214..293 CDD:197477 26/78 (33%)
SMC_prok_B 451..>664 CDD:274008 23/103 (22%)
SH3_Intersectin2_1 776..832 CDD:212921
SH3 881..932 CDD:473055
SH3_Intersectin_3 960..1011 CDD:212772
SH3_Intersectin2_4 1028..1086 CDD:212927
SH3 1101..1154 CDD:473055
RhoGEF 1181..1364 CDD:238091
PH_13 1383..1524 CDD:465218
C2_Intersectin 1524..1658 CDD:176021
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.