Protein Alignment Eps-15 and reps1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_005160888.1
• Gene: reps1 / 564535
• ZFINID: ZDB-GENE-030131-9536
• Length: 791
• Species: Danio rerio
• Alignment Length: 1059
• Identity: 194/1059 - (18%)
• Similarity: 318/1059 - (30%)
• Gaps: 451/1059 - (42%)

  Fly    31 IEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLSQAG---QVASMANIY 92
            :|...||:      ||:.|:.:|.:|...:..|...:..|::||||::|:|:|   ::.|: |..
Zfish    36 LELFRAAQ------LSNEVVLQITELCGATRLGHFGRSQFYIALKLIALAQSGLPLRLESL-NTV 93

  Fly    93 LDIANPP-KLGE--------------------LPKTMPSRIQTVPVASGGVANGDWSIGVIDRLK 136
            .|:..|. .:|:                    ||:. |.|:|...|::
Zfish    94 RDLPLPRFVMGKNEQETRHMVMFTDAENQGPFLPRP-PGRVQAKKVSA----------------- 140

  Fly   137 YEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIW-DLADQDKDGNLDMHEFVVAMHLVYQT 200
             .::.:...|:....|......|......|.|.|.  | ....|...||:|
Zfish   141 -HEMIQPCVPTADPQPDTTSPVVSPHQSPPTSPLA--WRKHKRQASGGNVD-------------- 188

  Fly   201 LQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAI 265
             ::.::|.|:.|..|:   |.|.|.|                    |||.:.|:.|
Zfish   189 -RQPSVPGVVWPHFRE---AQPGPVP--------------------GDGMWSAHSP--------- 220

  Fly   266 PPLPVA------VPPMTRIP--PVGAVSSQPLIQTDPLIPIGAPVMANAD-----WVVTPADLKR 317
            ||:..:      .||.:.:|  |..|.:....::|.|.......:.....     |.:|....:.
Zfish   221 PPVQESWVSFTDTPPSSTLPMHPPSAQTESSTVRTVPSAMTTNEIQRQTSGYDDPWKITDEQRQY 285

  Fly   318 FEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK 382
            :...|:....|..||:.|...|:.|.||.:|...|:.||.|.|.::.|.||:::|..|...|..:
Zfish   286 YINQFKTIQADLTGLIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVAR 350

  Fly   383 QRGVDPPHVLNANMVPPSM----------RATVAGVDLQPQEVKPTYSNPELEMISKEIEELARE 437
            :.|.|.|..|..:::|..:          .|...|....|.||.|..| |.:..:::...||.:.
Zfish   351 KNGYDLPEKLPESLMPKLIDLDDSAGVPEPAPEVGFSASPVEVTPNKS-PSMPSLNQNWPELNQS 414

  Fly   438 RRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLA 502
            ....||                   .||..:.:.||.|.::....|..           :||::.
Zfish   415 NEQWET-------------------FSERSSSSQTLTQFDSNIAPADP-----------DTAIVH 449

  Fly   503 NVSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKL 567
            .|.:.::.:         :.||||:.:         ||:.
Zfish   450 PVPIRMTPS---------KIHMQEMEL---------KRTG------------------------- 471

  Fly   568 TNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTL 632
            ::|...|.                                                      ..:
Zfish   472 SDHTHPTS------------------------------------------------------PLM 482

  Fly   633 TKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQ 697
            ||..:|.     :|....||                :..|..:.|  |.::.|..|.|
Zfish   483 TKPPELS-----DETKLAAA----------------IKFPGTAVG--DGYSSSDSFTS------- 517

  Fly   698 SGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQG-QVLSPNAQKSGP 761
                      .::|..|   |.|:.        :...|:.|         :| :|::|    ..|
Zfish   518 ----------DQEPISS---AVNRQ--------RSHSGTSP---------EGLKVVAP----PPP 548

  Fly   762 PPRPES-----------------PSP--------ALPPKKSKVPPPRPAPPRAAQPTGGFGSGGG 801
            ||||.:                 |:.        |.||    ..||||.|.:.:.|.|.....|.
Zfish   549 PPRPHASHSRSSSLDMNRNFAAVPAAGSQQAGVVAFPP----AVPPRPLPTQTSVPHGHRSVEGD 609

  Fly   802 G----------------GFADF------------DDFDN-----KLHHIPSAPSPSATALSPLPP 833
            |                .||||            ||.:|     :...:|.|.....||.:.:
Zfish   610 GLPAHTSTSPQQMPEQPNFADFSQFKAFAVDQPADDGENPSDGGQAERLPEAAGTMRTAKNDV-- 672

  Fly   834 TLPAPIPVVSGSSLLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALAS 898
                                     |..::.|:|.|             ...:|||.||.|....
Zfish   673 -------------------------QAEERNATTVN-------------SAKVSTPLAPPPKPVR 699

  Fly   899 LSTSGSGSVAGAGADLPS-----SVTITTAPSL--------------------NNQHLSRSNTPL 938
            ........:.....|||.     :..:.|.||:                    .|..|:|.|:.|
Zfish   700 RRLKSEDELRPDVDDLPQKSNVIATVLATQPSIPRSLGKDKKAIQASIRRNKETNTVLARLNSEL 764

  Fly   939 QNQR--------TADVKLE 949
            |.|.        :.:|:||
Zfish   765 QQQLKDLLEERISLEVQLE 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	15/50 (30%)
		EH	126..215	CDD:197477	14/89 (16%)
		EH	307..402	CDD:197477	28/109 (26%)
		SMC_prok_B	<423..>632	CDD:274008	21/208 (10%)
reps1	XP_005160888.1	EH	10..85	CDD:197477	17/54 (31%)
		EH	275..366	CDD:197477	27/90 (30%)