DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eps-15 and itsn2b

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:XP_005158835.1 Gene:itsn2b / 445153 ZFINID:ZDB-GENE-050309-102 Length:1837 Species:Danio rerio


Alignment Length:653 Identity:176/653 - (26%)
Similarity:279/653 - (42%) Gaps:156/653 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 WSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFV 191
            |:|...:|.|::|.|:||.|:.|.:.|.|.:...:.|.||..:|..||.|||.:|||.:|..||.
Zfish     8 WAITPEERDKHDQKFDSLLPAQGYVTGEKARNFFIQSGLPQPVLAAIWALADMNKDGKMDRLEFS 72

  Fly   192 VAMHLVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAG-AAMPRAPSGEGFGDGGFVANF 255
            :||.|:...||.:.:|:.||..:::|    |.|.|.||..|.| .|||..|         .:.|.
Zfish    73 IAMKLIKMKLQGQNLPTALPIIMKQP----PVPAPTMPAAPLGMGAMPNVP---------MMPNV 124

  Fly   256 PKDIAPP---AAIPPLPVAVP------PMTRIP-------PVGAV-----SSQPLIQTDPL---- 295
            |  |..|   |.:.|:||..|      |::.:|       |.|.:     |..||..|.||    
Zfish   125 P--ILTPIPIATMSPIPVMTPMMGTGLPVSMMPTISSQTLPNGPIAILQPSPMPLTSTLPLSSSF 187

  Fly   296 --IPIG-------------------------------APVMANADWVVTPADLKRFEEIFRQSDL 327
              .|:|                               :|....:||.|..|...::.:.|...|.
Zfish   188 SASPLGFSTTSMNKTSSLLDLGSSSSNSSPSTSLASNSPKGGPSDWGVPQASRLKYRQQFNSLDK 252

  Fly   328 DKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVL 392
            ...|.::|.:|:.....:.:.|..||.||.|.|.::.|||..::|.|||..|:..:.|...|..|
Zfish   253 LMSGYLTGPQVRTAMATTLLTQTQLAAIWNLADVDKDGKLKADEFILAMHLVDMAKMGQPLPLAL 317

  Fly   393 NANMVPPSMRATV------------AGV--DL----QPQEVKPTYS------------NPELEMI 427
            .:::||||:|..:            ||:  ||    .||:.:...:            |.|||..
Zfish   318 PSDLVPPSLRGKLGESMNGTTPSIYAGLAEDLCEPEPPQKSRNNLTFEDKFKKNMELGNAELEKR 382

  Fly   428 SKEIEEL-----------------ARERRVLETEIAQK-EADVRIKNGEVRSLQ--------SEL 466
            .:.::|.                 .|||...|.|:.:| |.::|::  ..|.|:        .||
Zfish   383 RQVLQEQQRREEERRAQKAREEQERREREARELELKRKREEEIRLE--RQRELERQREEERLKEL 445

  Fly   467 DTLTATLKQLENQR--GEAQKRLDDLQAQVSHNTAVLANV-----SLD-----ISRTNEQVT-KI 518
            :...|..|:||.|:  ...::|..:||.|.|.....:..:     ||:     :....:|:: |:
Zfish   446 ERKEAAKKELERQQQLEWERRRKQELQNQKSEEQEDIIKLRAKKRSLEMELEAVGNKQKQISDKL 510

  Fly   519 RDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQ--ATQLQISSV 581
            ||....:.:..||.| .:|.||   .....|.:||||:.:...|:|.:.|:..|  ..:|:..|:
Zfish   511 RDAQGRKRIHKNELE-MINQKR---DSCITEISSLQKQLEDFKRKLGQSTSEQQKLTDKLRSLSL 571

  Fly   582 RSMVTQLLET-QRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTL--TKEVQLPKDDP 643
            .|:.|..::| |..|.:..|.||...|..|| :..|...|: .|.|:.:|.:  .:|.|..::..
Zfish   572 NSVPTATVKTLQNNMEEKDLSCRKLKEQLNA-VEKETAAKL-ADMDQYKKDIQDLRESQRMQESA 634

  Fly   644 FEE 646
            .|:
Zfish   635 LEK 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 35/87 (40%)
EH 137..202 CDD:238009 26/64 (41%)
EH 307..402 CDD:197477 31/94 (33%)
EH 318..384 CDD:238009 20/65 (31%)
RILP-like <445..548 CDD:304877 29/124 (23%)
Spc24 529..>584 CDD:285486 17/56 (30%)
itsn2bXP_005158835.1 EH 7..99 CDD:197477 36/94 (38%)
EH 19..83 CDD:238009 26/63 (41%)
Amelogenin <80..183 CDD:197891 34/117 (29%)
EH 232..327 CDD:197477 31/94 (33%)
EH 243..308 CDD:238009 20/64 (31%)
TAF4 <453..592 CDD:296797 37/142 (26%)
DUF4349 <559..691 CDD:305044 22/81 (27%)
SH3 936..992 CDD:302595
SH3 1051..1102 CDD:302595
SH3_Intersectin_3 1126..1177 CDD:212772
SH3_Intersectin2_4 1198..1256 CDD:212927
SH3_Intersectin2_5 1271..1324 CDD:212929
RhoGEF 1355..1535 CDD:279015
PH_ITSN 1562..1692 CDD:270084
PH 1576..1684 CDD:278594
C2_Intersectin 1695..1829 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170589269
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.