DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eps-15 and CG9297

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	131/738 - (17%)
Similarity:	209/738 - (28%)	Gaps:	264/738 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 EPDFDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFN--- 683
            :.|.|...|...::..|..|....|.:.......||....:...|..|....     ||..:
  Fly   244 DEDLDGDGKVNHEDEDLDGDGVKNEKDDDLDGDGTNNSQDEDLDGDGVPNEK-----DDDLDGDG 303

  Fly   684 MSSGFDSGFDAFG--------QSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFA 740
            :.:..|...|..|        .||..:.......|....:|........:...|.. |..:.|..
  Fly   304 ILNEHDGDVDGDGVPNEHDHKDSGENADDDDDDDDEDDKEAVKKRSKREVDAAPVL-DIEAPPSP 367

  Fly   741 ALHAPTGQGQVLSPNAQKSG-------PPPRPES-----PSPALPPKKSKVPPP----------- 782
            |...|..:..|...:|::..       ..|..|:     |.|.:.|:....|.|
  Fly   368 AEEFPVEEEIVKEASAEEEAEVEAVKEEEPEQEAVQEPEPEPVVEPEAEVQPEPVQQEEEKAESA 432

  Fly   783 ------RPAP------------PRAA--------------QPTGGFGSGGGGGFADFDDFDNKLH 815
                  :|||            |.||              :|.    :.|....|| ||.|.|..
  Fly   433 EAKEEEKPAPVEEAEAEEESVQPEAAPKEPEAVQEEAQEDEPQ----TDGAQDAAD-DDDDTKPE 492

  Fly   816 -------HIPS------------------APSPSAT-----------------ALSPL------- 831
                   |||.                  .....||                 |:.||
  Fly   493 DELLWEGHIPENRRSRQHITELLQLDEEFNAREKATDNVAEIILRDIKRIYENAVKPLETLYKYR 557

  Fly   832 ---------PPTLPAPIPVVSG------SSLLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTL 881
                     |.....|:.:..|      ||:|:..|          ....|||
  Fly   558 DLSNRHFSDPEIFSKPLILFMGPWSGGKSSILNYLT----------DNEYTPN------------ 600

  Fly   882 LQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADV 946
               ||.|.|.||||..::...|:.:....|..|.:..|..        .|.:....|: :|...:
  Fly   601 ---SLRTGAEPSPAYFNILMWGNETEVLDGTQLAADYTFA--------GLQKFGQGLE-ERLRGL 653

  Fly   947 KLETKAV--VSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDY------RYEDPFSIKDP---- 999
            |:::|.:  |::.:..|.:..||..:          :..||.|.      |.:..|.:.||
  Fly   654 KMKSKILEKVNIVEIPGILEVRKQVS----------RVFPFNDACQWFIDRADIIFLVYDPAKLD 708

  Fly  1000 FAEEGEEELSEGKGADHKRNFAEDFSSGDEIGSAAKTLSNIVNN-NSIKPKAATPLNNDLLQQFD 1063
            ...|.|..|.:.||.:::...                   |:|. :::||:       :||:...
  Fly   709 VGPETEAILDQLKGREYQTRI-------------------ILNKADTVKPE-------ELLRVQG 747

  Fly  1064 AFNLNSSPAPSHHSGTSYHSNSKPSHDSQTALDA---FADFDDFAATLATT--------GGSGAA 1117
            |...|.||..|.......::.|..:|..|....|   .|....|...|.|.        ..|...
  Fly   748 ALIWNISPLMSSAQPPLMYTTSLWTHPYQDGAPARLLLAQERAFLRDLRTAIDKRIEHKIASARR 812

  Fly  1118 TTATTTGNTKLNNSFFDAFND--------------------NFSVIQSSSVPTGVVRPNDQRAKA 1162
            .......:.|:.:.:.:.||:                    |:.:.:..|..|.:.|
  Fly   813 FAVRVRNHAKMVDCYLNTFNNHKTLFGNKKRIADDIIDHPQNYHIYEGLSTLTNISR-------- 869

  Fly  1163 FDAFN-DNFEDQFKTSPNANFAK 1184
            :|..: :.:.|.|:.:|...|.|
  Fly   870 YDLPDPEVYRDFFRLNPLYEFKK 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477
		EH	137..202	CDD:238009
		EH	307..402	CDD:197477
		EH	318..384	CDD:238009
		RILP-like	<445..548	CDD:304877
		Spc24	529..>584	CDD:285486
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..569	CDD:293485	4/29 (14%)
		EHD	574..813	CDD:206740	61/308 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030