DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and itsn1

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:XP_005171028.1 Gene:itsn1 / 368504 ZFINID:ZDB-GENE-030616-226 Length:1751 Species:Danio rerio


Alignment Length:1209 Identity:285/1209 - (23%)
Similarity:446/1209 - (36%) Gaps:388/1209 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PVASGGVANGDWSIGVIDRLKYEQLFESLHPS-NGMLPGNKVKGVLMDSKLPMSILGTIWDLADQ 179
            |...|| .:..|.|.|.:|.|::|.|.||.|: .|.:.|::.:...:.|.||..||..||.|||.
Zfish     5 PTPFGG-GSDTWVISVDERAKHDQQFHSLTPTPAGFITGDQARNFFLQSGLPAPILAQIWALADM 68

  Fly   180 DKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGE 244
            :.||.:|||||.:||.|:...||...:|..|||.:::...:.|||.|.  ..|:..|||..|:  
Zfish    69 NNDGKMDMHEFSIAMKLIKLKLQGHPLPPSLPPSMKQQPISIPPPTPF--GIPSMGAMPGLPA-- 129

  Fly   245 GFGDGGFVANFPKDIAPPAAIPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMAN---- 305
                           .||..:||||..||.|...||:||..:.|:    |.:..|||.|..    
Zfish   130 ---------------VPPMPLPPLPPGVPGMGVSPPLGASVTPPV----PSLANGAPAMIQPLSG 175

  Fly   306 --------------------------------------ADWVVTPADLKRFEEIFRQSDLDKDGL 332
                                                  |||.|:.:...::.::|...|....|.
Zfish   176 FSHPGAVLNKTPSFNRSSIKLQKGQSVEAPSAPAAPPPADWAVSQSSRLKYRQLFNSHDKMMSGY 240

  Fly   333 VSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMV 397
            ::|.:.:.|.::|.:||..||.||.|.|.:|.||||.|:|.|||..::....|:..|.:|..:::
Zfish   241 LTGPQARTILMQSSLPQAQLATIWNLSDIDQDGKLTAEEFILAMHLIDMAMSGLPLPPLLPPDLI 305

  Fly   398 PPSMRATVAG----------VDLQPQEVKPTYSNPE----------------------------- 423
            ||:.|...:|          .||:.|| :|.....|                             
Zfish   306 PPTFRRMRSGSGVSVTSMHSTDLRSQE-EPEEEEKEAEKKLPVTFEDKKRENFERGNLELEKRRQ 369

  Fly   424 --LEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKR 486
              ||...||.|.||    .||.|..:::...|::  :.|..|.|||      ||||.||...::|
Zfish   370 ALLEQQRKEQERLA----ALEKEEQERKERERLE--QERRRQQELD------KQLERQRELERQR 422

  Fly   487 LDDLQAQVSHNTAVLANV----SLDISRTNEQ---VTKIRDQCHM-----QEVTINEQEGELNAK 539
            .::.:.::....|....:    .|:..||..|   ..:.|:|.::     ::.|:..:...||.|
Zfish   423 EEERRKEIERREAAKRELERQRQLEWERTRRQELLTQRNREQENIVLLKARKKTLEFELEALNDK 487

  Fly   540 RSELQ-KLKD--EEASLQK-EYDSNNR-------ELSKLTNHLQATQLQISSV----RSMVTQLL 589
            :|:|: ||:|  ...|:|: |.::.|:       |::.|...||.:|..:|.:    :.:..||.
Zfish   488 KSQLEGKLQDIRSRLSIQRHEIETTNKTRELRIAEITSLQQQLQESQQWLSRLIPDKQCLNDQLK 552

  Fly   590 ETQRQM--TDALLICRAAMENQNAELVSEYQLKIEPD---------------FDEARKTL----- 632
            :.|:..  .|:|...:.|:|.:.:   ::.|||.:.|               |:...|.|     
Zfish   553 QVQQNSLHRDSLNSLQRAIEMKES---TKQQLKEQLDAVEKETRSKLLEIDAFNTQLKELREIHN 614

  Fly   633 ----TKEVQLPKD-----------DPFEENNSGAANQAT-----NGFGSDPFSGQPVNKPAISTG 677
                .|:.:|..|           |..:...||..:..:     :|.|..|  ..||::..:|..
Zfish   615 KQQRQKQKELEADITQPSHDRKSIDSQDSRLSGTDDGVSPAWRDDGLGKAP--TPPVSQAWMSRV 677

  Fly   678 FDD--------SFNMSSGFDSGFDAFGQSGAGSAFGQTQRDP---FGSD-----------AFAAN 720
            .::        ..|:|..|.....| |:..|.|.:....:.|   |..:           .|.|.
Zfish   678 SEEENHSRAEIQDNLSKLFTQHPQA-GKIQAQSPWSMADKIPVSGFNQEKVKVVYYRAMYPFEAR 741

  Fly   721 KSNAITPEPG-------------------------KDDFGSDP-------------------FAA 741
            ..:.||..||                         |...|..|                   .|:
Zfish   742 SHDEITIHPGDIVMVKGEWVDESQTGEPGWLGGEIKGKTGWFPANYAEKIPESEVPLSLRASAAS 806

  Fly   742 LHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTG--GFGSGGGGGF 804
            ..||.....:.|.::..:..|..|.|..||      .:.||..|||    |||  ...|.....:
Zfish   807 SSAPKLGSHMSSASSSTTATPILPVSTEPA------SIAPPSSAPP----PTGPASSSSSASSNW 861

  Fly   805 ADFDDFDNKLHHIPSAPSPSATALS----------PLPPTLPAPIPVVSGSSLLDSFTLFDDPGQ 859
            |||           |...||.:|:.          |..||.|: :.|.||             ||
Zfish   862 ADF-----------STTWPSNSAVEKQDSDGWDAWPTQPTQPS-LSVPSG-------------GQ 901

  Fly   860 IHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITTAP 924
            |.:::|.||                            |:||.|....|.|.|..:         .
Zfish   902 IRQRSAFTP----------------------------ATLSGSSPSPVLGQGEKV---------E 929

  Fly   925 SLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDA-----FGEIGTRKAPTP----SLITGPTDF 980
            .|..|.|    .|.:.::...:......|::|.:.     |||:..::...|    .||:||.. 
Zfish   930 GLQAQAL----YPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQRGWFPKSYVKLISGPVR- 989

  Fly   981 KDDPFKDYRYEDPFSIKDPFAEEGE-EELSEGKGAD---------------HKRNFAED--FSSG 1027
            |....:....:.|.|:|.|.....: .||.||:.::               ::.|...|  |..|
Zfish   990 KSMSIESGSSDSPPSVKRPSPSLNKPTELGEGQNSNSNSMYPSKEYVAMYTYESNEQGDLTFQQG 1054

  Fly  1028 DEIGSAAK-------TLS---NIVNNNSIKPKAATPLNN 1056
            |.|....|       |:|   .:..:|.:|||.:..|.:
Zfish  1055 DVITVTKKEGDWWTGTVSGKIGVFPSNYVKPKESEGLGS 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 38/89 (43%)
EH 137..202 CDD:238009 27/65 (42%)
EH 307..402 CDD:197477 32/94 (34%)
EH 318..384 CDD:238009 24/65 (37%)
RILP-like <445..548 CDD:304877 28/115 (24%)
Spc24 529..>584 CDD:285486 18/69 (26%)
itsn1XP_005171028.1 EH 15..112 CDD:197477 38/96 (40%)
EH 26..91 CDD:238009 27/64 (42%)
EH 215..293 CDD:197477 27/77 (35%)
EH 226..292 CDD:238009 24/65 (37%)
CENP-F_leu_zip 475..611 CDD:287450 33/138 (24%)
RILP-like <546..645 CDD:304877 18/101 (18%)
SH3_Intersectin1_1 731..790 CDD:212920 9/58 (16%)
INTAP 790..932 CDD:293223 45/213 (21%)
SH3_Intersectin1_2 932..983 CDD:212922 9/54 (17%)
SH3 1034..1085 CDD:302595 10/50 (20%)
SH3_Intersectin1_4 1102..1166 CDD:212926
SH3_Intersectin1_5 1188..1241 CDD:212928
RhoGEF 1272..1452 CDD:279015
PH_ITSN 1478..1609 CDD:270084
PH 1495..1601 CDD:278594
C2_Intersectin 1612..1746 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170589272
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.840

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