Protein Alignment Eps-15 and Reps

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: NP_609487.2
• Gene: Reps / 34542
• FlyBaseID: FBgn0032341
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 1016
• Identity: 200/1016 - (19%)
• Similarity: 307/1016 - (30%)
• Gaps: 361/1016 - (35%)

  Fly    16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSD-PSGKGFLDKPGFFVALKLVSL 79
            |...::..|.:.||.:..:.|.:..:.:.:::..:..|..|:. ||....:.:..|:..|||::.
  Fly    13 YSELFQCCDVEKTGKVPMLKATELFRSADIANETVIEITGLAGIPSTALHISRTQFYSCLKLIAA 77

  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESL 144
            .||........|......|     ||........|.|||   |.||               ..:|
  Fly    78 HQAAMPLRQELILATFPLP-----LPHFSWKEAVTAPVA---VENG---------------LTAL 119

  Fly   145 HP-----SNGMLPGNKVKGVLMD-SKLPMSILGTIWDLADQDKDGNLDMHEFV--VAMHLVYQTL 201
            .|     ....|..|..:..|.| |.:|.:             |..::.:|.|  ...|
  Fly   120 PPPPPTDRRNSLRRNSQQEQLQDTSDVPST-------------DSEVEQNESVDDATGH------ 165

  Fly   202 QKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFG---DGGFVANFPKDIAPPA 263
                             |.|..          |..:..:.|.|..|   .||.....|:..:..:
  Fly   166 -----------------GRGTD----------GCGVVSSSSRENVGRRRGGGTGGGSPEAWSTNS 203

  Fly   264 AIPPLPVAVPPMTRIPPVGAVSSQP-----------------LIQTD----------------PL 295
            ..|            .|..:|:.:|                 |:.|:                .|
  Fly   204 DSP------------TPTNSVAERPWAQDTLWQGLLGDEHRQLLGTEEESSDRHSSDDDDNESEL 256

  Fly   296 IPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCD 360
            :.|         :.:||...:.:.:.||....|..||:||...::.|.||.||...|..||.|||
  Fly   257 VTI---------YQITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEELRHIWQLCD 312

  Fly   361 TNQSGKLTVEQFALAMWFVERKQRGV----DPPHVLNANMVPPSMRATVAGVDLQ-----PQEVK 416
            ..:.|.|::.:|..||..|..::..:    ..||.|:.|::..:...:..||...     |||
  Fly   313 VTRDGALSLSEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAASGSGQGVTSSSSAALPQE-- 375

  Fly   417 PTYSNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRG 481
                                          ..|||:...|
  Fly   376 ------------------------------PPEADLLHLN------------------------- 385

  Fly   482 EAQKRLDDLQAQVSHNTAVLANV--SLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQ 544
                  ||.:...:.||.:..|:  |...|:....|...::..::..::.:.|... ::||
  Fly   386 ------DDDEDDHTDNTIIAGNLSGSSTTSKPRPNVPSDKNIMNLSSISTSSQASN-SSKR---- 439

  Fly   545 KLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQ 609
                 ||:.|... ..||.:|...|..:.....:||..|                     |:::.
  Fly   440 -----EATPQNSL-GKNRSISNSPNVEKPVSGTVSSTAS---------------------AVDST 477

  Fly   610 NAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSG-----AANQATNGFGS-------- 661
            |   ||....|    |.|:..|....||         :.:|     ||..|.:|..|
  Fly   478 N---VSSQWTK----FSESPTTSAVSVQ---------STTGAAPVVAAGAAASGASSPGLKPVLF 526

  Fly   662 -------DPFSGQPVNKPA------ISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFG 713
                   |..|...:..|.      |.|....|...|:..:            ||..|.:..|..
  Fly   527 DMKRSAQDVVSNPQILHPVPLRVTPIGTAIASSAESSNENE------------SAVAQREDSPKA 579

  Fly   714 -SDAFAANKSNAITP----EPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPE------S 767
             |.....|:|:|:.|    ..|.....|....|:..|  |.:.|........|||:.|      .
  Fly   580 ISSTTVNNQSSAVVPGISGVAGSSHRDSSDLRAIQRP--QAKKLPAKNSALPPPPQREPSIGSTG 642

  Fly   768 PSPALPPK---------KSKVPPPRPAPPRAAQ---------------PTGG-----------FG 797
            ||.:..|:         ..|.|||.| |||..:               .|||           |.
  Fly   643 PSESQEPQAAYVASSLASKKEPPPLP-PPRPHRHARSSSLDLNKFKIGATGGAQQAEITAQASFD 706

  Fly   798 SGGGGGFADFDDF----------DNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFT 852
            .....|||||..|          :.:||.:|.|..|...|:.|     |..|.:......:.:|.
  Fly   707 MQTSTGFADFTHFADEGAANVVDEQQLHSLPPAAPPPQAAVVP-----PTRITLQQAQQRVSAFE 766

  Fly   853 LFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPS 893
            ::..| |..:.:.|.|...|...|.|....||. ..|:|.|
  Fly   767 VYRKP-QTPRGSQSPPQQPPPPAPAVGLTTQTG-QLPSAES 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	13/66 (20%)
		EH	126..215	CDD:197477	12/96 (13%)
		EH	307..402	CDD:197477	30/98 (31%)
		SMC_prok_B	<423..>632	CDD:274008	32/210 (15%)
Reps	NP_609487.2	EH	262..345	CDD:197477	26/82 (32%)