DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and Itsn2

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	XP_038969030.1	Gene:	Itsn2 / 313934	RGDID:	1590890	Length:	1716	Species:	Rattus norvegicus

Alignment Length:	1246	Identity:	257/1246 - (20%)
Similarity:	438/1246 - (35%)	Gaps:	374/1246 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQD 180
            |.|..|..| .|:|...:|.|:::.|::|.||.|.:.|::.:...:.|.||..:|..||.|:|.:
  Rat     6 PTAMNGGPN-MWAITSEERTKHDKQFDNLKPSGGYITGDQARTFFLQSGLPAPVLAEIWALSDLN 69

  Fly   181 KDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPG----------GAGPPP-----KPAMPP 230
            |||.:|..||.:||.|:...||.:.:|.||||.:::|.          |.|..|     :|..|.
  Rat    70 KDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIHQPLPPV 134

  Fly   231 PPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPL--------------PVAVPPMTRIPP- 280
            .|..|.:..|.||         .:.|..:.|...:|.:              |:::|..:...|
  Rat   135 APITAPLSSATSG---------TSIPPLMMPAPLVPSVSTSSLPNGTASLIQPLSIPYSSSTLPH 190

  Fly   281 -------VGAVSSQPLIQTDPLIPIG--------------APVMANADWVVTPADLKRFEEIFRQ 324
                   :|......:.:...||.:|              :|....::|.|......::.:.|..
  Rat   191 ASSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPSRLKYRQKFNS 255

  Fly   325 SDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPP 389
            .|....|.:||.:.::..::|.:.|..||.||.|.|.:..|:|..|:|.|||...:..:.|...|
  Rat   256 LDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADIDGDGQLKAEEFILAMHLTDMAKAGQPLP 320

  Fly   390 HVLNANMVPPSMRA-----TVAGV--------DLQPQEVKP-TYSNPELEMISKEIEELARERRV 440
            ..|...:||||.|.     ::.|.        :.:||:..| |:.:.......:...||.:.|:|
  Rat   321 LTLPPELVPPSFRGGKQIDSINGTLPSYQKTQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQV 385

  Fly   441 LETEIAQKEADVRIK------NGEVRSLQS-------ELDTLTATLKQLENQRGEAQKRLDDLQA 492
            | .|..|:||:.:.:      ..:.|.||.       ||:      |:||.||...::|.::.:.
  Rat   386 L-MEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE------KRLEKQRELERQREEERRK 443

  Fly   493 QVSHNTAVLANVSLDISRTNEQVTKIRD----------------------QCHMQEVTINEQE-- 533
            ::....:.   :|..:.|..|.::..:|                      |..::...|..||
  Rat   444 EIERRESC---ISFPLMREREWISVYKDRKGFMAELWKPGSCAAKQELERQRRLEWERIRRQELL 505

  Fly   534 GELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQ------ATQ------------LQISS 580
            .:.|.::.|:.:|..::.||..|.::.|.:..:::..||      .||            |:|..
  Rat   506 NQKNREQEEIVRLNSKKKSLHLELEAVNGKHQQISGRLQDVRIRKQTQKTELEVLDKQCDLEIME 570

  Fly   581 VRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEA---RKTLTKE--VQLPK 640
            ::.:..:|.|.|.::  ..|:....:.|   |.:...||...||...:   :|:..||  .|..|
  Rat   571 IKQLQQELQEYQNKL--IYLVPEKQLLN---ERIKNMQLSNTPDSGISLLHKKSSEKEELCQRLK 630

  Fly   641 D--DPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTG-FDDS-----FNMSSGFDSGF----- 692
            :  |..|:..:...::      .|.|:.|      :..| .|||     .::.|..::.|
  Rat   631 EQLDALEKETASKLSE------MDSFNNQ------LKCGNMDDSVLQCLLSLLSCLNNLFLLLKE 683

  Fly   693 --DAFG-QSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSP 754
              :::. |..|.....:.:||..  ......:...|..:..:|:      ||..|..|:..:...
  Rat   684 LRESYNTQQLALEQLHKIKRDKL--KELERKRLEQIQKKKLEDE------AARKAKQGKENLWKE 740

  Fly   755 NAQKSGPPPRPESPSPALPPKKS---------KVPPPRPAPPRAA-------------QPTGGFG 797
            :.:|     ..|.....|..:||         |....:....||.             .....|.
  Rat   741 SIRK-----EEEEKQKRLQEEKSQDRTQEEERKTEAKQSETARALVNYRALYPFEARNHDEMSFN 800

  Fly   798 SG----------GGGGFADFDDFDNKLHHIP-----------SAPSP-----------SATALSP 830
            ||          |..|:. :..|..|....|           ..|||           |||:.:|
  Rat   801 SGDIIQVDEKTVGEPGWL-YGSFQGKFGWFPCNYVEKMLSSDKTPSPKKALLPPAVSLSATSAAP 864

  Fly   831 LPPTLPAPIPVVSGSSLLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPA 895
            .|.....|.||....::  ||:..:......:::|.|...:|.:|..:|
  Rat   865 QPLCSNQPAPVTDYQNV--SFSNLNVNTTWQQKSAFTRTVSPGSVSPIH---------------- 911

  Fly   896 LASLSTSGSGSVAGAGADLPSSVTIT-TAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDA 959
                   |.|.   |..:|.:....: ||...|:.:.|:.:                 |::|.:.
  Rat   912 -------GQGQ---AVENLKAQALCSWTAKKENHLNFSKHD-----------------VITVLEQ 949

  Fly   960 -----FGEIGTRKAPTP----SLITGPTDFKDDPFKDYR--YEDPFSIKDPFAE----------- 1002
                 |||:...:...|    .:|.|....:.:|...|.  .:.|.|...|..|
  Rat   950 QENWWFGEVHGGRGWFPKSYVKIIPGSEVKRGEPEALYAAVNKKPTSTAYPVGEEYIALYSYSSV 1014

  Fly  1003 --------EGEEELSEGKGADHKRNFAEDFSSGDEIGSAAKTLSNIVNNNSIKPKAATPLNNDLL 1059
                    ||||.|...|..:....     |.|:..|        |..:|.::||
  Rat  1015 EPGDLTFTEGEELLVTQKDGEWWTG-----SIGERTG--------IFPSNYVRPK---------- 1056

  Fly  1060 QQFDAFNLNSSPAPSHHSGTSYHSNSKPSHDSQTALDAFADFDDFAATLATTGGSGAATTATTTG 1124
            .|.:..|.:.|.|          ||.||               :.|...:....|||...:...|
  Rat  1057 DQENVGNASKSGA----------SNKKP---------------EIAQVTSAYAASGAEQLSLAPG 1096

  Fly  1125 N----TKLNNS 1131
            .    .|.|:|
  Rat  1097 QLILILKKNSS 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	34/88 (39%)
		EH	137..202	CDD:238009	23/64 (36%)
		EH	307..402	CDD:197477	29/94 (31%)
		EH	318..384	CDD:238009	20/65 (31%)
		RILP-like	<445..548	CDD:304877	25/139 (18%)
		Spc24	529..>584	CDD:285486	16/74 (22%)
Itsn2	XP_038969030.1	EH	15..107	CDD:197477	34/91 (37%)
		KLF3_N	106..>185	CDD:410554	16/87 (18%)
		EH	238..317	CDD:197477	22/78 (28%)
		PTZ00121	<347..797	CDD:173412	89/489 (18%)
		SH3_Intersectin2_1	780..836	CDD:212921	8/56 (14%)
		SH3_Intersectin2_2	921..972	CDD:212923	10/67 (15%)
		SH3_Intersectin2_3	1004..1055	CDD:212925	11/63 (17%)
		SH3_Intersectin2_4	1076..1134	CDD:212927	8/32 (25%)
		SH3_Intersectin2_5	1149..1202	CDD:212929
		RhoGEF	1233..1413	CDD:214619
		PH_13	1431..1574	CDD:406942
		C2_Intersectin	1574..1708	CDD:176021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840