DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and EHD2

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:NP_055416.2 Gene:EHD2 / 30846 HGNCID:3243 Length:543 Species:Homo sapiens


Alignment Length:98 Identity:39/98 - (39%)
Similarity:60/98 - (61%) Gaps:1/98 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 GGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGN 184
            |.....:|.: ..|:.||:::|.:|.|::|.|.|:|.|..::.:|||.|:||.||.|:|.|:||.
Human   437 GSDDEAEWVV-TKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGM 500

  Fly   185 LDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP 217
            ||..||.:|.||:...|:...:|:.||..|..|
Human   501 LDDEEFALASHLIEAKLEGHGLPANLPRRLVPP 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 36/88 (41%)
EH 137..202 CDD:238009 29/64 (45%)
EH 307..402 CDD:197477
EH 318..384 CDD:238009
RILP-like <445..548 CDD:304877
Spc24 529..>584 CDD:285486
EHD2NP_055416.2 EHD_N 24..56 CDD:374864
EHD 60..300 CDD:206740
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 65..72
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 91..92
KPF loop, caveolar targeting. /evidence=ECO:0000269|PubMed:22323287 120..122
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 153..156
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 219..222
DUF5600 288..394 CDD:375591
Mediates membrane-binding. /evidence=ECO:0000250|UniProtKB:Q8BH64 320..340
EH 443..536 CDD:197477 38/92 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..543 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154116
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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