Protein Alignment Eps-15 and ede1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: NP_595112.1
• Gene: ede1 / 2540824
• PomBaseID: SPBC800.10C
• Length: 1116
• Species: Schizosaccharomyces pombe
• Alignment Length: 1351
• Identity: 279/1351 - (20%)
• Similarity: 461/1351 - (34%)
• Gaps: 425/1351 - (31%)

  Fly    16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLS 80
            ::..:|:.|.:..|.|....|..||:||||:..||.:||.::|...:|||...||.:|::||:|:
pombe    13 FDQLFKIADKQDIGVITGEEAVPFLEKSGLAPQVLGQIWQIADAENRGFLTFSGFVIAMRLVALA 77

  Fly    81 Q---------AGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDW--SIGVIDR 134
            |         :|::...|:|::...:..|..:|.:  |:.     |:||..::|.:  .|...:.
pombe    78 QEKLPFDYKKSGKIPYFADIHISGVDSSKFVQLNR--PNN-----VSSGDGSDGSFLPPISSDEM 135

  Fly   135 LKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQ 199
            .:|:|:|.::.|::|::.|::...:...:.|...||..:|:|.|..|.|.||:.||...||::..
pombe   136 TRYQQMFTTVCPTDGLMDGDRASSIFGRAPLSTEILARVWNLVDTHKRGALDIREFNTGMHIINL 200

  Fly   200 TLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAA 264
            .|.               |....||....|...|.||...:.|.
pombe   201 LLN---------------GSLKSPPVSISPSFIASAASTSSVSA--------------------- 229

  Fly   265 IPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDK 329
                |...|.::|.|||.|          |.||:..|      |.:...||..|.::|...|...
pombe   230 ----PSQYPGLSRSPPVQA----------PNIPVSDP------WAIPSQDLTSFCQLFSNVDKAH 274

  Fly   330 DGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNA 394
            .|.|||.|....|:.|.:|:..||.||.|.|||.:|||.:.:|.::::.::.|..|.:.|.||.:
pombe   275 KGYVSGSEAYSFFLASKLPEDVLAQIWDLSDTNSNGKLNIGEFCISLYLIKLKLSGKELPKVLPS 339

  Fly   395 NM-------------VPPSMRATVAGVDLQPQEVKPTYSNPEL-------EMISKEIEEL----- 434
            :|             ||.|:.:.|      |..:.....||.|       ..::...|:|
pombe   340 SMLSSVAPLMQKSKSVPTSIPSVV------PANISSPNPNPTLAPNPTGPSRVTSGTEDLLSLDA 398

  Fly   435 -------------------------------------------------ARERRVLETEIAQ--- 447
                                                             |:......|...|
pombe   399 TPFSPTLAPQHTSSNATKHSAPPVTKSAPFPVVSPLQLNHTPGFPTSPAAKPNSPTSTFFPQSSF 463

  Fly   448 ----------KEADVR-------------IKNGEVRSLQSELDTLTATLKQLENQRGEAQK---- 485
                      |.:.||             :.:.|...|.:|:..|.:.|.|::....:.||
pombe   464 GQTIAKNTMDKPSAVRTSVPSQLAAPIPQVASAEQLKLAAEVPKLESQLSQVKKSNDDLQKSSRD 528

  Fly   486 ---RLDDLQAQVS-------HNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKR 540
               .|.|::|:||       ...|....:||||.....|..::..:..:.|.|:|..:.:...|.
pombe   529 VAANLSDVKAKVSEIRKAYDEELAKAKQISLDIETNKAQTEQVNREYSILEATLNALQKQNKQKG 593

  Fly   541 SELQKLKDEEASLQKEYDSNNRELSKLTNH-------LQATQLQISSVRSMVTQLLETQRQMTDA 598
            ..|:::..|..:.:...:|:|..:.:|.:.       |....||:..:...:..|.|..:.::..
pombe   594 EVLEQVVAESEAAKNMVESSNASIQQLKSEVADKEQTLAQLHLQLDEMTQRLVSLDEESKAVSQR 658

  Fly   599 LLICRAAMENQNAELVS------EYQLKIEPDFDEARK--------TLTKEVQLPKDDPFEENNS 649
            .|.....:.|...:|.:      |:..::|.:..|..|        .||:|...|:.|
pombe   659 KLDLEYKINNSKTQLATATEEYHEHSKQLEAEKQELSKLEDGLKSVNLTEEAPKPEVD------- 716

  Fly   650 GAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFG--------QSGAGSAFGQ 706
                 :|..|.|...:|...:||.:.   |.:.::.:..:| |||..        .|...||...
pombe   717 -----STPRFPSFTSNGITTDKPTLP---DTTSSVPTQHNS-FDAMHNTLRSPSLNSNNSSAHAS 772

  Fly   707 T-QRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSP 770
            | .|:||.:    ...|.|.:|   ..:|....||:...|....:..|.:...|...|..:|.
pombe   773 TVSRNPFHN----LKISGASSP---VSNFWESEFASAVFPRSISKTTSLSVNNSSVNPSLDSE-- 828

  Fly   771 ALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSATALSPLPPT- 834
              |.:.|.:..|:.........:......|....:|.........:  :|.....|:..|:..|
pombe   829 --PVQLSNMEEPQHQDSSVVDVSTSASQRGSPVLSDLSKLTGSARN--TAEPVENTSAEPIENTS 889

  Fly   835 LPAPIPVVSGSSLLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASL 899
            .|.|..:.                  :||.|:.|...|....|:        ||||...|.:
pombe   890 APTPFEIA------------------NKQQATEPISAPFATETI--------STPAPVKPPV--- 925

  Fly   900 STSGSGSVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIG 964
                                                .|.:..|:|...:..:|...:.|.|
pombe   926 ------------------------------------PPSRRDRSAQDGVVQQATPHIQDEF---- 950

  Fly   965 TRKAPTPSLITGPTDFK--DDPFKDYRYEDPFSIKDPFAEEGEEELSEGKGADHKRNFAEDFSSG 1027
                       .|..|.  ||.......|.|.|                       |.:...|.|
pombe   951 -----------PPIQFNEIDDDESSSDEEPPMS-----------------------NLSPQISIG 981

  Fly  1028 DEIGSAAKTLSNIVNNNSIKPKAATPLNNDLLQQFDAFNLNSSPAPSHH---SGTSY--HSNSK- 1086
                       ::.|..|    |.|.|                |.|:|.   |.|::  |.||:
pombe   982 -----------SVTNYTS----AVTEL----------------PDPNHQLEMSTTTHVQHPNSET 1015

  Fly  1087 -PSHDSQTALDAFADFDDFAATLATTGGSGAA--TTATTTGNTKLNNSF-FDAFNDNFSVIQSSS 1147
             ||.......|             ||.|:..|  .|..|..:.:::..| ||..|::.:  ....
pombe  1016 IPSSTENQYFD-------------TTSGAFEANSNTEVTVNSNEVSQPFDFDTANESDN--DDDE 1065

  Fly  1148 VPTGVVRPNDQRAKAFDAFN--DNFEDQFKTSPNANFAKFDGFEAHNFSSD 1196
            :|   |:.....:.|.||||  |.|::||     ||....:..:..|.|:|
pombe  1066 LP---VQQVVSGSLANDAFNVDDEFDNQF-----ANLQAAEIKDDDNSSTD 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	26/74 (35%)
		EH	126..215	CDD:197477	22/90 (24%)
		EH	307..402	CDD:197477	35/107 (33%)
		SMC_prok_B	<423..>632	CDD:274008	49/330 (15%)
ede1	NP_595112.1	EH	13..79	CDD:238009	25/65 (38%)
		EH	138..203	CDD:238009	20/64 (31%)
		EH	252..345	CDD:197477	33/98 (34%)
		PHA03247	<334..508	CDD:223021	23/179 (13%)
		SMC_N	<484..>698	CDD:481474	40/213 (19%)