DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and ucp8

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_595633.2	Gene:	ucp8 / 2540786	PomBaseID:	SPBC83.01	Length:	829	Species:	Schizosaccharomyces pombe

Alignment Length:	966	Identity:	201/966 - (20%)
Similarity:	332/966 - (34%)	Gaps:	244/966 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLS 80
            ::...:.:.|:....|.......||.|.||...:|::|||..|...||.||:...:...:|:|.:
pombe    14 FDRLLESLHPEQKDLIPGSVIGPFLLKFGLPQKILAKIWDYCDQEDKGSLDRNQVYACFRLISQA 78

  Fly    81 QAGQVASMANI-YLDIANPPKL--------------GELPKTMPSRIQTVPVASGGVANGDWSIG 130
            |.|  |::..: |....:||.|              .|.....|.||   |:      |.|
pombe    79 QRG--ATLQELDYNKAGDPPILPKQAKDDHHIKRSSSETADFTPFRI---PI------NPD---- 128

  Fly   131 VIDRLKYEQLF--------ESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDM 187
              :|.:||:.|        :|..|  |.:|.:..|.:|:.|.|..::|..||:|||....|.|:|
pombe   129 --ERSEYEKEFRENLRGHEDSARP--GCMPSSIAKPILLKSSLHYAVLAQIWNLADSAHVGYLEM 189

  Fly   188 HEFVVAMHLVYQTLQKRTI--PSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGG 250
            :::|:|.|||....|...|  |..||.::.:   :.....|||.
pombe   190 YQYVIARHLVAICKQYNLIHLPRSLPADVIE---SAKSETPAMN--------------------- 230

  Fly   251 FVANFPKDIAPPAAI------PPLPVAVPPMTRIPPVGA-----------VSSQPLIQT-DPLIP 297
              .|..:.:..|:.:      ....::....:::..:.|           .||.|  || ||
pombe   231 --TNIEQGVTQPSLVNTEQLSHQQSISSTKSSKLDEISADNNAQSAVDNKYSSPP--QTIDP--- 288

  Fly   298 IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTN 362
                 .||...::||.|...|.::|.:.|.:..|.:.|.|....|:.|.:....||.||...||.
pombe   289 -----QANIKALITPEDRSNFYQLFSKIDNENKGYIVGGEAVPFFMASHLDSEELARIWDTVDTQ 348

  Fly   363 QSGKLTVEQFALAMWFVERKQRGVDPPHVL--NANMVPPSMRATVAGVDLQPQEVKP------TY 419
            ..|.:..::||:||..::.:..|.....:|  :.|...|:|:..:...|.......|      ..
pombe   349 DRGYIDKDEFAVAMEIIKLRLSGKSLASILAYDDNPTEPTMQQNLVSDDTNASTAVPVAFTNDNV 413

  Fly   420 SNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQ 484
            ||..|.:...|...........:|...:..|....:|.     .|.|:.|.:..:....|
pombe   414 SNVPLSVADNEPNSTLNLLASSDTAAFEPTAVSLHENP-----SSSLEDLQSAFQNTSFQ----- 468

  Fly   485 KRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCH-----MQEVTINEQEGELNAKRSELQ 544
               |.:..|...|||       |||:..|..:..:.|..     .|.:.: :..|......|.|.
pombe   469 ---DQVSTQNQANTA-------DISQNTESGSSTQGQMFGIPPTTQSIPL-KMAGFPGGVNSSLT 522

  Fly   545 KLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQ 609
            .:|:|||..:.......|...::...:......||::....:..|.|....|.......|..:.|
pombe   523 DIKEEEAVSENAPQQEERSFEQIKTSIHIAPENISAIEESKSVPLPTSFATTIPGSTSAALDDQQ 587

  Fly   610 NAELVSEYQLKIEPDFDEARKTLTKEVQLPK-DDPFEENNSGAANQATNGFGSDPFSGQPVNK-- 671
            ..|...|     |||......|..::.::.| ::..|....|.....|        ||:.:.:
pombe   588 TTEAPFE-----EPDEPAHEPTEEEQEEMRKLEEKIESTKYGLETIQT--------SGKTIKQRI 639

  Fly   672 -----------------PAISTGFDDSFNMSSGFDSGFDA-FGQSGAG--SAFGQTQRDPFGSDA 716
                             .||........:.|...|..... .|..|.|  .|..:.::.....|:
pombe   640 EQKKTRLMILREELQELDAIKEEAQKQISQSLIADQQLSTQIGSVGMGKKQAVKELRKLQAKIDS 704

  Fly   717 FAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPP 781
            ..|:..                     :|.|.|.|                .|||:.|:.:.. |
pombe   705 IIADSM---------------------SPMGTGAV----------------NSPAIKPQVTPA-P 731

  Fly   782 PRPAPPRAAQPTGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSS 846
            |.|||..|.:                       ||.|  |.|..:::||..|  |||:...:.|:
pombe   732 PTPAPTPAVK-----------------------HHPP--PPPVRSSISPSMP--PAPLTHANSST 769

  Fly   847 LLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTS 902
            .::..:..:.|.|.::           ::...:.|||..||.......|:.:|..:
pombe   770 PMNYVSQPESPPQSYE-----------SIQNDNELLQELLSMGFPREKAVIALEAT 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	18/65 (28%)
		EH	126..215	CDD:197477	32/98 (33%)
		EH	137..202	CDD:238009	25/72 (35%)
		EH	307..402	CDD:197477	26/96 (27%)
		EH	318..384	CDD:238009	19/65 (29%)
		RILP-like	<445..548	CDD:304877	20/107 (19%)
		Spc24	529..>584	CDD:285486	10/54 (19%)
ucp8	NP_595633.2	EH	14..80	CDD:238009	18/65 (28%)
		EH	124..223	CDD:197477	34/115 (30%)
		EH	133..204	CDD:238009	25/72 (35%)
		EH	304..370	CDD:238009	19/65 (29%)
		EF-hand_7	305..362	CDD:290234	16/56 (29%)
		UBA	790..826	CDD:197551	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	43	1.000	Domainoid score	I3659
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001628
OrthoInspector	1	1.000	-	-		otm47169
orthoMCL	1	0.900	-	-		OOG6_101578
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810