DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and Synrg

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	XP_006533042.1	Gene:	Synrg / 217030	MGIID:	1354742	Length:	1330	Species:	Mus musculus

Alignment Length:	1303	Identity:	250/1303 - (19%)
Similarity:	397/1303 - (30%)	Gaps:	420/1303 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LSQAGQVASMANI---YLDIANPPKLGELP--KTMPSRIQTVPVASGGVANGDWSIGVIDRLKYE 138
            :|| |.:|..|.|   .:..|..|.||:.|  ...|:..|..|......|.           :.:
Mouse    70 MSQ-GPIAMQAGIPMGPMPAAGVPFLGQPPFLSMRPAGPQYTPDMQKQFAE-----------EQQ 122

  Fly   139 QLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIW-DLADQDKD-------GNLDMHEFVVAMH 195
            :.||.   ...:|...:.:....:.|..:.:|.::. ...::::|       ||||.......||
Mouse   123 KRFEQ---QQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKNRDDALEAIKGNLDGFSRDAKMH 184

  Fly   196 LVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPP-------PAGAAMPRAPSGEGFGDG--GF 251
                                 |..|..|.|...|..       ...:|.|......||..|  .|
Mouse   185 ---------------------PTPASHPKKQDCPTSSHSTKTVSPSSAFPGEDEFSGFVQGPVEF 228

  Fly   252 VANFPKDIAPP--AAIP---------------PLPVAVPPMT--------RIPPVGAVSSQPLIQ 291
            .|..|...|||  :.:|               |||.|..|::        :||.:.|.|:...:|
Mouse   229 PACGPSSTAPPFQSFLPSTPLGQLHTQKVGTQPLPPAQAPVSFAIHGVHGQIPCLSAASASHSVQ 293

  Fly   292 -----TDPLIPIGAPVMANAD------------WVVTPADLKRFEEIFRQSDLDKDGLVSG---- 335
                 .:..:.:...|.|:..            ..:.|...|....:...:....||.|||
Mouse   294 KAGPSLEEKLLVSCDVSASGQEHIKLNTPDAGHKAIVPGSSKNCPGLMAHNRGAVDGCVSGPASA 358

  Fly   336 -----------------------------------------------------------LEVKDI 341
                                                                       .::..|
Mouse   359 EAEKTSDQTLSKEESGVGVFPSQDPAQSRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPI 423

  Fly   342 FIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVD--PPHVLNANMVPPSMRAT 404
            .:.||:|:.:|..||||.:....|:||.|:....:..|...||||.  .|..|  :..|.:...|
Mouse   424 LMSSGLPRETLGQIWALANRTTPGRLTKEELYTVLAMVAVTQRGVPAMSPDAL--SQFPAAPIPT 486

  Fly   405 VAGVDL-------QPQEVK--PTYSNP--------ELEMI----------SKEIEELARERRVLE 442
            ::|..:       ||..:.  ||.|.|        .:.::          |..........:|.:
Mouse   487 LSGFPMTLPTPVSQPTAMPSGPTGSMPLTLGQPIMGINLVGPVGGAAAPTSSGFMPAYPSNQVGK 551

  Fly   443 TEIAQKEADVR-----IKNGEVRSLQSELDTLTATLKQLENQRGEAQKRL----DDLQAQVSHNT 498
            ||    |.|.:     .|:|.:....::...:.|:.|...:|.|.:...|    ...:|. :...
Mouse   552 TE----EDDFQDFQDASKSGSIDDSFTDFQEMPASSKTSNSQHGNSAPSLLIPFPGTKAS-TDKY 611

  Fly   499 AVLANVSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRE 563
            ||...:|.|  :.:|.....               ||...|.|..::|         |..::::.
Mouse   612 AVFKGISTD--KPSENPASF---------------GESGDKYSAFREL---------EQTTDSKP 650

  Fly   564 LSKLTNHLQATQLQIS----SVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPD 624
            |.:.....::|.....    .....|:.|....:....:.....||.:.|.       |:|...:
Mouse   651 LGESFAEFRSTGTDDGFTDFKTADSVSPLEPPTKDTFPSAFASGAAQQTQT-------QVKTPLN 708

  Fly   625 FDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFD 689
            .::.....:.:....|..||....|.|.:.:|.        .||....|.|.....:...|...|
Mouse   709 LEDLDMFSSVDCSGEKQVPFSATFSTAKSVSTR--------PQPAGSAAASAALASTKTSSLADD 765

  Fly   690 SG-FDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLS 753
            .| |:.||:....::.|  ::|.|..  |.|..:::|:.||.    .||.:.||.
Mouse   766 FGEFNLFGEYSNPASAG--EQDDFAD--FMAFGNSSISSEPK----ASDKYEALR---------- 812

  Fly   754 PNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFG--SGGGGGFA----------- 805
                        |..||:  |..|........||.||.....|.  |..|.|.|
Mouse   813 ------------EEVSPS--PLSSSTVEGAQHPPAAATKYDVFKQLSLEGAGLAMEEFKENTSST 863

  Fly   806 ----DFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFTLF----DDPGQIHK 862
                ||.||     |.....|.|                  |..||.:....|    :|...:
Mouse   864 KSEDDFADF-----HSSKFSSTS------------------SDKSLGEKAVAFRHAKEDSSSV-- 903

  Fly   863 QAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALA------SLSTSGSGSVAGAGADL-----PS 916
                                 .||..|:....::.      :||......:|..|.||     .|
Mouse   904 ---------------------KSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDS 947

  Fly   917 SVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFK 981
            |:.:   |:::.||...:.:.|.::   |...||     .|.||.........|    |...:|:
Mouse   948 SLDL---PTVSGQHPPAAGSALASE---DALPET-----AFPAFASFKDMMPQT----TEQKEFE 997

  Fly   982 DDPFKDYRYEDPFSIKDPFAEEGEEELSEGKG---ADHK--RNFAEDFSSGDEIGSAAKTLSNIV 1041
            ...|:|:..:|.     |..:..:|.......   |.|:  :..|:||.......|.......:|
Mouse   998 SGDFQDFTRQDM-----PTVDRSQETSCPSPASSVASHETPKEGADDFGEFQSEKSKISKFDFLV 1057

  Fly  1042 NNNSIKPKAATPLNNDLLQQFDAFNLNSSPAPSHHSGTSYHSNSKPSHDSQTALDAFADFDDFAA 1106
            .|:..|.|::..:....|..|| .::..|...|...|....|.|.||    .||:  ..|.|.:.
Mouse  1058 ANSQSKMKSSEEMIKSELATFD-LSVQGSHKRSLSLGDKEISRSSPS----PALE--QPFRDRSN 1115

  Fly  1107 TLATTGGSGAATTA------TTTGNTKLN-----------NSFFDAF---NDNFSVIQSSSVPTG 1151
            ||:    ..||...      ..||..:.|           .|..|..   ||..:.|.||:|.|.
Mouse  1116 TLS----ERAALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALDVIKKANDTLNGISSSAVCTE 1176

  Fly  1152 VVR 1154
            |::
Mouse  1177 VIQ 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	1/2 (50%)
		EH	126..215	CDD:197477	12/96 (13%)
		EH	137..202	CDD:238009	12/72 (17%)
		EH	307..402	CDD:197477	28/171 (16%)
		EH	318..384	CDD:238009	19/128 (15%)
		RILP-like	<445..548	CDD:304877	20/111 (18%)
		Spc24	529..>584	CDD:285486	8/58 (14%)
Synrg	XP_006533042.1	Med15	<30..>242	CDD:312941	43/207 (21%)
		ARGLU	<114..147	CDD:373772	5/46 (11%)
		EH	<415..466	CDD:238009	14/50 (28%)
		SAP130_C	<469..>537	CDD:374297	11/69 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900