DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and EPS15

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:XP_016856104.1 Gene:EPS15 / 2060 HGNCID:3419 Length:933 Species:Homo sapiens


Alignment Length:1008 Identity:294/1008 - (29%)
Similarity:438/1008 - (43%) Gaps:233/1008 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            |||.||:.:|...||.:.|..||.|||||||.|::|.:||||:|..|||.|:|..|||||:||:.
Human    18 VYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVAC 82

  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGD--WSIGVIDRLKYEQLFE 142
            :|.|...|::::.|.:. ||:..:         .:.|:...|.:..:  |::...|:.||:.:|:
Human    83 AQNGLEVSLSSLNLAVP-PPRFHD---------TSSPLLISGTSAAELPWAVKPEDKAKYDAIFD 137

  Fly   143 SLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIP 207
            ||.|.||.|.|:|||.||::||||:.|||.:|:|:|.|.||.||..||.|||.|||..|:|..:|
Human   138 SLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVP 202

  Fly   208 SVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAV 272
            ..|||.|       .||........:|:.                          ..||....|.
Human   203 MSLPPAL-------VPPSKRKTVSISGSV--------------------------RLIPSSASAK 234

  Fly   273 PPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLE 337
            .....:|.||            ::|..||:   ..|||:||:..:::|||.::|.|.||.|||||
Human   235 ESYHSLPSVG------------ILPTKAPL---RQWVVSPAEKAKYDEIFLKTDKDMDGFVSGLE 284

  Fly   338 VKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQ-RGVDPPHVLNANMVPPSM 401
            |::||:|:|:|...||.||:||||...|||:.:|||||...:.:|. :|:||||||...|:|||.
Human   285 VREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSD 349

  Fly   402 RATVAGVDLQPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSEL 466
            ||::....:....|....:..||:.::.||.:|.||:..:|.::.:||..::.:..||:.||.|:
Human   350 RASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEV 414

  Fly   467 DTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTINE 531
            ......|::|:.|:.:.|:.||:|..|.:.....|..|....:...:.::.::.:...||..|:.
Human   415 QRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIST 479

  Fly   532 QEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQ-- 594
            .|.||...|.||.:|:.|.|.|::..:|...:|..|..|||.:|.:|||::..:.::.:.:..  
Human   480 YEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNS 544

  Fly   595 ---------------MTDALLICRAAME--NQNAELVSEYQLKIEP------------------- 623
                           .||...:..::.|  |.|..:..:..|:.||                   
Human   545 QLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVT 609

  Fly   624 DFDEARKTLTKEV--------QLPKDDPFEENNSG----AANQATNGFGSDPFSGQPVNKPAIST 676
            |.:|....:|::|        ...::|||..::|.    .|:...:.|.||||.|....|     
Human   610 DENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFK----- 669

  Fly   677 GFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAA 741
              ||.|.....|  |.|.|..|           |||.||.|....::.....      .:|||:|
Human   670 --DDPFGKIDPF--GGDPFKGS-----------DPFASDCFFRQSTDPFATS------STDPFSA 713

  Fly   742 LHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGG-FGSGG-GGGF 804
                .....:.|....|...|..|.....|             |...|..|... ||:.. ||||
Human   714 ----ANNSSITSVETLKHNDPFAPGGTVVA-------------ASDSATDPFASVFGNESFGGGF 761

  Fly   805 ADFDDFDNKLHHIP--SAPSPSAT---------------------ALSPL--PPTLPAPIPVVSG 844
            |||.......:..|  ||.|.|.:                     ||.|.  .||.|.|:|    
Human   762 ADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLP---- 822

  Fly   845 SSLLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAG 909
                        ||:.......:|:|             ..|:.|..|.|               
Human   823 ------------PGKRSINKLDSPDP-------------FKLNDPFQPFP--------------- 847

  Fly   910 AGADLPSSV-------TITTAPSLNNQHLSRSN 935
             |.|.|...       ..|:|.:..|:....||
Human   848 -GNDSPKEKDPEIFCDPFTSATTTTNKEADPSN 879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009 36/65 (55%)
EH 126..215 CDD:197477 46/90 (51%)
EH 137..202 CDD:238009 37/64 (58%)
EH 307..402 CDD:197477 51/95 (54%)
EH 318..384 CDD:238009 35/66 (53%)
RILP-like <445..548 CDD:304877 27/102 (26%)
Spc24 529..>584 CDD:285486 21/54 (39%)
EPS15XP_016856104.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154126
Domainoid 1 1.000 107 1.000 Domainoid score I6512
eggNOG 1 0.900 - - E1_KOG0998
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 457 1.000 Inparanoid score I1583
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D360276at33208
OrthoFinder 1 1.000 - - FOG0001628
OrthoInspector 1 1.000 - - otm40921
orthoMCL 1 0.900 - - OOG6_101578
Panther 1 1.100 - - LDO PTHR11216
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R396
SonicParanoid 1 1.000 - - X924
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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