DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and Itsn2

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:NP_001185897.1 Gene:Itsn2 / 20403 MGIID:1338049 Length:1685 Species:Mus musculus


Alignment Length:1220 Identity:254/1220 - (20%)
Similarity:422/1220 - (34%) Gaps:430/1220 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQD 180
            |.|..|..| .|:|...:|.|:::.|::|.||.|.:.|::.:...:.|.||..:|..||.|:|.:
Mouse     6 PTAMNGGPN-MWAITSEERTKHDKQFDNLKPSGGYITGDQARTFFLQSGLPAPVLAEIWALSDLN 69

  Fly   181 KDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPG----------GAGPPP-----KPAMPP 230
            |||.:|..||.:||.|:...||.:.:|.||||.:::|.          |.|..|     :|..|.
Mouse    70 KDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIHQPLPPV 134

  Fly   231 PPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPL--------------PVAVPPMTRIPP- 280
            .|....:..|.||         .:.|..:.|...:|.:              |:::|..:...| 
Mouse   135 APIATPLSSATSG---------TSIPPLMMPAPLVPSVSTSSLPNGTASLIQPLSIPYSSSTLPH 190

  Fly   281 -------VGAVSSQPLIQTDPLIPIG--------------APVMANADWVVTPADLKRFEEIFRQ 324
                   :|......:.:...||.:|              :|....::|.|......::.:.|..
Mouse   191 ASSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPSRLKYRQKFNS 255

  Fly   325 SDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPP 389
            .|....|.:||.:.::..::|.:.|..||.||.|.|.:..|:|..|:|.|||...:..:.|...|
Mouse   256 LDKGMSGYLSGFQARNALLQSNLSQTQLATIWTLADIDGDGQLKAEEFILAMHLTDMAKAGQPLP 320

  Fly   390 HVLNANMVPPSMRA-----TVAGV--------DLQPQEVKP-TY----------SNPELE----- 425
            ..|...:||||.|.     :|.|.        :.:||:..| |:          .|.|||     
Mouse   321 LTLPPELVPPSFRGGKQVDSVNGTLPSYQKTQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQV 385

  Fly   426 -----------MISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQ--------SELDTLTA 471
                       ...||.||..|::|.|:.:..:|:.::..:..:.|.|:        .|::...|
Mouse   386 LMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKEIERREA 450

  Fly   472 TLKQLENQRGEAQKRL--DDLQAQVSHNTAVLANVS-------LDISRTN---EQVT-KIRD--- 520
            ..::||.||....:||  .:|.:|.:.....:..:|       |::...|   :|:: :::|   
Mouse   451 AKQELERQRRLEWERLRRQELLSQKTREQEDIVRLSSRKKSLHLELEAVNGKHQQISGRLQDVQI 515

  Fly   521 --------------QCHMQEVTINEQEGEL----------------------------------- 536
                          ||.::.:.|.:.:.||                                   
Mouse   516 RKQTQKTELEVLDKQCDLEIMEIKQLQQELKEYQNKLIYLVPEKQLLNERIKNMQLSNTPDSGIS 580

  Fly   537 -----NAKRSEL-QKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQ-LLETQRQ 594
                 ::::.|| |:||::..:|:||..|...|:....|     ||:..|:...|.| ||.....
Mouse   581 LLHKKSSEKEELCQRLKEQLDALEKETASKLSEMDSFNN-----QLKCGSMDDCVLQCLLSLLSC 640

  Fly   595 MTDALLICRAAMENQNAELVSEYQL-KIEPD------------------FDEA------------ 628
            :.:..|:.:...|:.|.:.::..|| ||:.|                  .|||            
Mouse   641 LNNLFLLLKELRESYNTQQLALEQLHKIKRDKLKEIERKRLEQIQKKKLEDEAARKAKQGKENLW 705

  Fly   629 RKTLTKE---------VQLPKDDPFEENNSGAANQA------TNGFGSDPFSGQPVNKPAISTGF 678
            |:::.||         .:..:|...||.....|.|:      .|.....||..:.          
Mouse   706 RESIRKEEEEKQKRLQEEKSQDKTQEEERKAEAKQSETASALVNYRALYPFEARN---------- 760

  Fly   679 DDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALH 743
            .|..:.|||.....|.......|..:|..|                     ||  ||..|...:.
Mouse   761 HDEMSFSSGDIIQVDEKTVGEPGWLYGSFQ---------------------GK--FGWFPCNYVE 802

  Fly   744 APTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGGFADFD 808
                  :|||  ::|            ||.|||:.:||                           
Mouse   803 ------KVLS--SEK------------ALSPKKALLPP--------------------------- 820

  Fly   809 DFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQIHKQAASTPNPTPI 873
                       ..|.|||:.|..||........||.|:|..:.|.       .:::|.|...:|.
Mouse   821 -----------TVSLSATSTSSQPPASVTDYHNVSFSNLTVNTTW-------QQKSAFTRTVSPG 867

  Fly   874 TVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTIT-TAPSLNNQHLSRSNTP 937
            :|..:|                       |.|.   |..:|.:....: ||...|:.:.|:.:  
Mouse   868 SVSPIH-----------------------GQGQ---AVENLKAQALCSWTAKKENHLNFSKHD-- 904

  Fly   938 LQNQRTADVKLETKAVVSVFDA-----FGEIGTRKAPTP----SLITGPTDFKDDPFKDYR--YE 991
                           |::|.:.     |||:...:...|    .||.|....:.:|...|.  .:
Mouse   905 ---------------VITVLEQQENWWFGEVHGGRGWFPKSYVKLIPGNEVQRGEPEALYAAVTK 954

  Fly   992 DPFSIKDPFAEE----GEEELSEGKGADHKRNFAE----DFSSGDEI-----------GSAAKTL 1037
            .|.|...|....    ||:.:     |.:..:..|    .|:.|:||           ||..:. 
Mouse   955 KPTSTAYPVTSTAYPVGEDYI-----ALYSYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGER- 1013

  Fly  1038 SNIVNNNSIKPKAATPLNNDLLQQFDAFNLNSSPAPSHHSGTSYHSNSKP 1087
            :.|..:|.::||          .|.:..|.:.|.|          ||.||
Mouse  1014 TGIFPSNYVRPK----------DQENFGNASKSGA----------SNKKP 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 34/88 (39%)
EH 137..202 CDD:238009 23/64 (36%)
EH 307..402 CDD:197477 29/94 (31%)
EH 318..384 CDD:238009 20/65 (31%)
RILP-like <445..548 CDD:304877 27/181 (15%)
Spc24 529..>584 CDD:285486 17/95 (18%)
Itsn2NP_001185897.1 EH 15..107 CDD:197477 34/91 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..242 2/21 (10%)
EH 238..317 CDD:197477 22/78 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..382 10/46 (22%)
Smc 350..>747 CDD:224117 75/401 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..742 5/25 (20%)
SH3_Intersectin2_1 747..803 CDD:212921 16/94 (17%)
INTAP 806..883 CDD:374674 29/161 (18%)
SH3_Intersectin2_2 883..934 CDD:212923 10/67 (15%)
SH3_Intersectin2_3 973..1024 CDD:212925 10/56 (18%)
SH3_Intersectin2_4 1045..1103 CDD:212927
SH3_Intersectin2_5 1118..1171 CDD:212929
RhoGEF 1202..1381 CDD:366202
PH_13 1400..1554 CDD:374702
C2_Intersectin 1543..1677 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167844363
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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