DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and Reps1

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_033074.2	Gene:	Reps1 / 19707	MGIID:	1196373	Length:	795	Species:	Mus musculus

Alignment Length:	1026	Identity:	199/1026 - (19%)
Similarity:	300/1026 - (29%)	Gaps:	402/1026 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPS 110
            :|||| :|.:|...:..|:..:..|::|||||:::|:|....:.:|     |..|...||:.:.|
Mouse    46 NDVVL-QIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESI-----NTVKDLPLPRFVAS 104

  Fly   111 RIQ-----TVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGML---PGNKVKGVLMDSKLPM 167
            :.:     ....:|.....|.:| |||..          .|..|.:   ||:.      |:..|.
Mouse   105 KNEQESRLAASYSSDSENQGSYS-GVIPP----------PPGRGQVKKGPGSH------DAVQPR 152

  Fly   168 SILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRK----PGGAGPPPKPAM 228
                   ..|:|.:.              |...:..:..|...|...||    |.| |...:|..
Mouse   153 -------PSAEQQEP--------------VSPVVSPQQSPPTSPHTWRKHSRHPSG-GNSERPLT 195

  Fly   229 PPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPP-------AAIPPL-------PVAVPPMTRIP 279
            .|.|..:....|.:|...||..:....|   .||       |..||.       |.:|...|.:.
Mouse   196 GPGPFWSPFGDAQAGSSAGDAVWSGQSP---PPPQDNWVSFADTPPTSALLTMHPASVQDQTTVR 257

  Fly   280 PVGAVSS------QPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEV 338
            .|.:.::      |.....||             |.:|....:.:...|:....|.:|.:.|...
Mouse   258 TVASAATANEIRRQSSSYEDP-------------WKITDEQRQYYVNQFKTIQPDLNGFIPGSAA 309

  Fly   339 KDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSM-R 402
            |:.|.||.:|...|:.||.|.|.::.|.||:::|..|...|..::.|.|.|..|..:::|..: .
Mouse   310 KEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDL 374

  Fly   403 ATVAGVDLQPQEV--------KPTYSNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEV 459
            ...|.|..||.||        .|...:|.:..:::...||.:.....||
Mouse   375 EDSADVGEQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWET---------------- 423

  Fly   460 RSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHM 524
               .||..:.:.||.|.::....|..           :||::..|.:.::.:         :.||
Mouse   424 ---FSERSSSSQTLTQFDSNIAPADP-----------DTAIVHPVPIRMTPS---------KIHM 465

  Fly   525 QEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLL 589
            ||:.:         ||:.                         ::|...|.
Mouse   466 QEMEL---------KRTS-------------------------SDHTNPTS-------------- 482

  Fly   590 ETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSGAANQ 654
                                        .|.::|                 .|..|||
Mouse   483 ----------------------------PLLVKP-----------------SDLSEEN------- 495

  Fly   655 ATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAA 719
                                      ..|.|..|.||
Mouse   496 --------------------------KINSSVKFPSG---------------------------- 506

  Fly   720 NKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSP-------------- 770
               |.:......|.|.|||.....:.|.|......:...:.|||.|..|.|
Mouse   507 ---NTVDGYSSSDSFPSDPEQIGSSVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTF 568

  Fly   771 ------------ALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGG----------------GFADF 807
                        |.||    ..||||.|.:|..|:........|                .||||
Mouse   569 AVTTGQQQAGVVAHPP----AVPPRPQPSQAPGPSVHRPVDADGLITHTSTSPQQIPEQPNFADF 629

  Fly   808 DDFDNKLHHIPSAPSPSATALSPL---PPTLPAPIPVVSGSSL----LDSFTLFDDPGQIHKQAA 865
            ..|:     :.:|.:.|....|..   |..|||.......|||    .||           |...
Mouse   630 SQFE-----VFAASNVSEEQDSEAEKHPEVLPAEKASDPSSSLRAAQADS-----------KAEE 678

  Fly   866 STPNPTPITVPTVHTLLQTSLSTPAAPSP-------------------------ALASLSTSGSG 905
            .|....|..|        :..:||.||.|                         .||::.||...
Mouse   679 KTATNVPANV--------SKGTTPLAPPPKPVRRRLKSEDELRPDVDEHTQKTGVLAAVLTSQPS 735

  Fly   906 SVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSV 956
            .....|.|..:...........|..|:|.|:.|| |:..|| ||.:..:.|
Mouse   736 IPRSVGKDKKAIQASIRRNKETNTVLARLNSELQ-QQLKDV-LEERISLEV 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	13/35 (37%)
		EH	126..215	CDD:197477	15/91 (16%)
		EH	137..202	CDD:238009	9/67 (13%)
		EH	307..402	CDD:197477	27/95 (28%)
		EH	318..384	CDD:238009	20/65 (31%)
		RILP-like	<445..548	CDD:304877	15/102 (15%)
		Spc24	529..>584	CDD:285486	4/54 (7%)
Reps1	NP_033074.2	EFh	14..81	CDD:298682	13/35 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..238		33/167 (20%)
		EH	278..369	CDD:197477	27/103 (26%)
		EH	289..355	CDD:238009	20/65 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..433		13/71 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..720		66/435 (15%)
		MCLC	<645..734	CDD:283562	23/107 (21%)
		Interaction with RALBP1	651..795		36/155 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840