DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and ehs-1

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_001022499.2	Gene:	ehs-1 / 173985	WormBaseID:	WBGene00001224	Length:	796	Species:	Caenorhabditis elegans

Alignment Length:	884	Identity:	256/884 - (28%)
Similarity:	384/884 - (43%)	Gaps:	172/884 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DFARVCGKHIGVYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKP 68
            |...:...|..|:...:..::|.|...|.|..||.|||||.|:..||.:||:|||....|.|||.
Worm     3 DSYAIATPHNDVFNHAFAEMNPHGAPRIGAAEAATFLKKSNLAMPVLGQIWELSDSQKVGSLDKR 67

  Fly    69 GFFVALKLVSLSQAGQVASMANIYLDIANPPK--------------------LGELPKTMP---- 109
            |.|||.|||:.:|.|:..:.:::|.....||:                    :|..|...|
Worm    68 GAFVAFKLVAAAQQGKPVANSSLYDSSLQPPRFAPPVPPANMQHHFQPSFPSVGRAPPVPPPPHP 132

  Fly   110 ------SRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMS 168
                  |..|:.|..........|.|...|:.||:.:|:||:|.||.|.|..|:.|||:|.|...
Worm   133 SHPYSISSQQSSPAHPSSAFPPQWPITPTDQAKYDSIFQSLNPVNGKLSGAHVRPVLMNSGLDAH 197

  Fly   169 ILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPGGA----GPPPKPAMP 229
            .|..||:|:|||||||||..|..||:||||::||...:|:.|||.|..|..|    ..|...|.|
Worm   198 ALARIWELSDQDKDGNLDRIEMSVALHLVYRSLQSDPVPAQLPPNLIHPSKAMYAHSSPNFAAPP 262

  Fly   230 PPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPPMTRIPPVGAVSSQPLIQTDP 294
            .||......||.|.....|.....::...:  |.|.||           .|..|.|:|..:....
Worm   263 HPPRPMMGSRAGSVTSLDDVNMSQSYSATM--PRAYPP-----------QPGRAYSAQAHVNGSR 314

  Fly   295 LIPIGAPVMAN--------ADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRS 351
            ......|:.|:        .:|.:...|   :.:.|.|:|.:|||||.|::::...:.:|:..:.
Worm   315 TSGASTPISASHSIHSFPAGEWPINTGD---YADQFAQTDTNKDGLVDGMDMRAPMMTTGLSAQI 376

  Fly   352 LADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVDLQ----- 411
            ||.:|||.|..:.|:|.:|||||.|..::..:||...|..|..:::|||.|.......|.
Worm   377 LAHVWALADIKKCGQLNLEQFALTMHLLDMAKRGESIPSELPLHLIPPSFRPPTEPSALHHPAQS 441

  Fly   412 ---PQ-------EVKPTY--SNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQS 464
               ||       |:|...  .|.|::.:::.|:.:..||:..|..:.|.|||:.|||..:::||.
Worm   442 VSTPQLPEATSMEIKEALEGENEEMKQLAESIQSMLVERKTAEEAVLQLEADMTIKNSSIKNLQV 506

  Fly   465 ELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTI 529
            ||.||.:|:||||.|:|||.:||.|...|:.                     ::...|..|:.|.
Worm   507 ELATLESTVKQLERQKGEATRRLADYDTQIE---------------------QLESACKAQKETK 550

  Fly   530 NEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQ 594
            .:.|..:.....:.:..:|.:|:.:||.:...:|:..|.|       |..:||..:.:  ||.::
Worm   551 EDTEKRMQQIDEDAKNAEDCKANDEKEMEELKKEIEMLDN-------QFKTVRGEIVK--ETSQR 606

  Fly   595 MTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSGAANQATNGF 659
                        |.:.|||.:     :|      ||....::|:.|.|...||.:....|.::..
Worm   607 ------------EQKVAELTT-----LE------RKEARDQIQMEKLDAAIENTTKLTEQVSDAV 648

  Fly   660 GSDPFSGQPV---NKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANK 721
            .........:   .:..:||..|.|..      |....:|::...|:....|:.|   |.||:.:
Worm   649 EKSEEEMVQILRSQQRLLSTVIDQSLL------SDDTVYGETAGTSSQNHVQQPP---DPFASAR 704

  Fly   722 SN-AITPEPGKDDFGS----------DPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPK 775
            :| |..|....|.|||          ||||       ||...|.:......|.:|..|.|| |||
Worm   705 ANPAADPFAQVDQFGSSGHFDAAFPTDPFA-------QGGFPSDSGFAQSAPAKPAPPRPA-PPK 761

  Fly   776 KSKVPPPR----PAPPRAAQPTGGFGSGGGGGFADFDDF 810
            .::..|..    |:..::.||         .|||||.||
Worm   762 SARETPVNDPFAPSQGQSTQP---------AGFADFADF 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	30/65 (46%)
		EH	126..215	CDD:197477	45/88 (51%)
		EH	137..202	CDD:238009	35/64 (55%)
		EH	307..402	CDD:197477	33/94 (35%)
		EH	318..384	CDD:238009	24/65 (37%)
		RILP-like	<445..548	CDD:304877	30/102 (29%)
		Spc24	529..>584	CDD:285486	11/54 (20%)
ehs-1	NP_001022499.2	EH	15..81	CDD:238009	30/65 (46%)
		EH	155..249	CDD:197477	47/93 (51%)
		EH	166..231	CDD:238009	35/64 (55%)
		EH	335..427	CDD:197477	33/94 (35%)
		EH	343..409	CDD:238009	24/65 (37%)
		TMF_TATA_bd	446..539	CDD:289123	35/113 (31%)
		RILP-like	457..>548	CDD:304877	34/111 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159127
Domainoid	1	1.000	88	1.000	Domainoid score	I5076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31881
Inparanoid	1	1.050	298	1.000	Inparanoid score	I1644
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S4078
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360276at33208
OrthoFinder	1	1.000	-	-		FOG0001628
OrthoInspector	1	1.000	-	-		oto19380
orthoMCL	1	0.900	-	-		OOG6_101578
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R396
SonicParanoid	1	1.000	-	-		X924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880