DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and Itsn1

DIOPT Version :9

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:XP_006522994.1 Gene:Itsn1 / 16443 MGIID:1338069 Length:1743 Species:Mus musculus


Alignment Length:1153 Identity:260/1153 - (22%)
Similarity:418/1153 - (36%) Gaps:391/1153 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 GELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLP 166
            ||..:||..    .|...||..: .|:|.|.:|.|::|.|.||.|..|.:.|::.:.....|.||
Mouse    19 GERNRTMAQ----FPTPFGGSLD-VWAITVEERAKHDQQFLSLKPIAGFITGDQARNFFFQSGLP 78

  Fly   167 MSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP------------GG 219
            ..:|..||.|||.:.||.:|..||.:||.|:...||...:||.|||.:::.            ||
Mouse    79 QPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSTLPPVMKQQPVAISSAPAFGIGG 143

  Fly   220 -AGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIA--PPAAIPPLPVAVPPMTRIPPV 281
             |..||..|:.|.|.| ::|            .|...|..::  ||||:|||....||:.:..|.
Mouse   144 IASMPPLTAVAPVPMG-SIP------------VVGMSPPLVSSVPPAAVPPLANGAPPVIQPLPA 195

  Fly   282 GAVSSQPLIQTDPLIPIGAPVMAN-----------------ADWVVTPADLKRFEEIFRQSDLDK 329
            .|..:..|.::......|.....|                 |:|.|..:...::.::|...|...
Mouse   196 FAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASAPPAAEWAVPQSSRLKYRQLFNSHDKTM 260

  Fly   330 DGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNA 394
            .|.::|.:.:.|.::|.:||..||.||.|.|.:|.||||.|:|.|||..::....|...|.||..
Mouse   261 SGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPP 325

  Fly   395 NMVPPSMRATVAGVDL----------------------QPQEVKP-TYSNPELEMISKEIEELAR 436
            ..:|||.|...:|..:                      ||::..| |:.:.:.|...:...||.:
Mouse   326 EYIPPSFRRVRSGSGMSVISSSSVDQRLPEEPSSEDEQQPEKKLPVTFEDKKRENFERGSVELEK 390

  Fly   437 ER------------RVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDD 489
            .|            |:.:.|.|::|...|.:..:.|..|.||:      ||||.||...::|.::
Mouse   391 RRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE------KQLEKQRELERQREEE 449

  Fly   490 LQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTIN----EQEGE--LNAKRS----ELQ 544
            .:.::....|.        .|..|:..::..:.:.::..:|    ||||.  |.|:|.    ||:
Mouse   450 RRKEIERREAA--------KRELERQRQLEWERNRRQELLNQRNKEQEGTVVLKARRKTLEFELE 506

  Fly   545 KLKDEE--------------ASLQKEYDSNNR-------ELSKLTNHLQATQLQISSV----RSM 584
            .|.|::              |:.::|.:|.|:       |::.|...||.:|..:..:    :.:
Mouse   507 ALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQIL 571

  Fly   585 VTQLLETQRQM--TDALLICRAAME-------------------------------NQNAEL--- 613
            ..||.:.|:..  .|:||..:.|:|                               ||..||   
Mouse   572 SDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVERETRSKLQEIDVFNNQLKELREI 636

  Fly   614 VSEYQLKIEPDFDEA--------RKTLTKEVQLPKDD--------------------------PF 644
            .|:.||:.:...:.|        ||:|  |::..|:|                          |.
Mouse   637 HSKQQLQKQRSLEAARLKQKEQERKSL--ELEKQKEDAQRRVQERDKQWLEHVQQEEQPRPRKPH 699

  Fly   645 EEN--------NSGAANQATNGFGSDPFSG--QPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSG 699
            ||:        ....|.:.......|..|.  .|..:||                       :..
Mouse   700 EEDRLKREDSVRKKEAEERAKPEMQDKQSRLFHPHQEPA-----------------------KLA 741

  Fly   700 AGSAFGQTQRDPFGSDA--------------FAANKSNAITPEPG-----KDDFGSDPFAALHAP 745
            ..:.:..|::.|....|              |.:...:.||.:||     |.::..:      :.
Mouse   742 TQAPWSTTEKGPLTISAQESVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDE------SQ 800

  Fly   746 TGQGQVLSPNAQ-KSG--PP------PRPESPSPALP---------PKKSKVPPPRPAPPRAAQP 792
            ||:...|....: |:|  |.      |..|.|:||.|         ||.:....|.|.|..:::|
Mouse   801 TGEPGWLGGELKGKTGWFPANYAEKIPENEVPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEP 865

  Fly   793 TGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSATALSP---------LPPTLPAPIPVVSGSSLL 848
                 |.....:|||           |:..||::...|         ..|:|..|          
Mouse   866 -----STTPNNWADF-----------SSTWPSSSNEKPETDNWDTWAAQPSLTVP---------- 904

  Fly   849 DSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSG-SVAGAGA 912
                   ..||:.:::|.||                :.:|.::|||.|      |.| .|.|..|
Mouse   905 -------SAGQLRQRSAFTP----------------ATATGSSPSPVL------GQGEKVEGLQA 940

  Fly   913 DLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDA-----FGEIGTRKAPTP- 971
                                ::..|.:.::...:......|::|.:.     |||:..:|...| 
Mouse   941 --------------------QALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPK 985

  Fly   972 ---SLITGP----TDFKDDPFKDYRYEDPFSIK---DPFAE---EGEE 1006
               .||:||    |.....|     .|.|.|:|   .|.|:   .|||
Mouse   986 SYVKLISGPVRKSTSIDTGP-----TESPASLKRVASPAAKPAIPGEE 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 36/88 (41%)
EH 137..202 CDD:238009 24/64 (38%)
EH 307..402 CDD:197477 33/94 (35%)
EH 318..384 CDD:238009 24/65 (37%)
RILP-like <445..548 CDD:304877 28/112 (25%)
Spc24 529..>584 CDD:285486 21/89 (24%)
Itsn1XP_006522994.1 EH 39..132 CDD:197477 36/92 (39%)
PLN02983 <155..226 CDD:215533 20/83 (24%)
EH 238..333 CDD:197477 33/94 (35%)
PTZ00121 <355..739 CDD:173412 79/422 (19%)
SH3 766..825 CDD:388381 12/64 (19%)
INTAP 825..939 CDD:374674 37/168 (22%)
SH3_Intersectin1_2 939..990 CDD:212922 9/70 (13%)
SH3_Intersectin1_3 1028..1079 CDD:212924 1/1 (100%)
SH3_Intersectin1_4 1096..1160 CDD:212926
SH3_Intersectin1_5 1180..1233 CDD:212928
RhoGEF 1260..1443 CDD:238091
PH_13 1462..1615 CDD:374702
C2_Intersectin 1604..1738 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167844365
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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