Protein Alignment Eps-15 and Itsn1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_006522994.1
• Gene: Itsn1 / 16443
• MGIID: 1338069
• Length: 1743
• Species: Mus musculus
• Alignment Length: 1153
• Identity: 260/1153 - (22%)
• Similarity: 418/1153 - (36%)
• Gaps: 391/1153 - (33%)

  Fly   102 GELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLP 166
            ||..:||..    .|...||..: .|:|.|.:|.|::|.|.||.|..|.:.|::.:.....|.||
Mouse    19 GERNRTMAQ----FPTPFGGSLD-VWAITVEERAKHDQQFLSLKPIAGFITGDQARNFFFQSGLP 78

  Fly   167 MSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP------------GG 219
            ..:|..||.|||.:.||.:|..||.:||.|:...||...:||.|||.:::.            ||
Mouse    79 QPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSTLPPVMKQQPVAISSAPAFGIGG 143

  Fly   220 -AGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIA--PPAAIPPLPVAVPPMTRIPPV 281
             |..||..|:.|.|.| ::|            .|...|..::  ||||:|||....||:.:..|.
Mouse   144 IASMPPLTAVAPVPMG-SIP------------VVGMSPPLVSSVPPAAVPPLANGAPPVIQPLPA 195

  Fly   282 GAVSSQPLIQTDPLIPIGAPVMAN-----------------ADWVVTPADLKRFEEIFRQSDLDK 329
            .|..:..|.::......|.....|                 |:|.|..:...::.::|...|...
Mouse   196 FAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASAPPAAEWAVPQSSRLKYRQLFNSHDKTM 260

  Fly   330 DGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNA 394
            .|.::|.:.:.|.::|.:||..||.||.|.|.:|.||||.|:|.|||..::....|...|.||..
Mouse   261 SGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPP 325

  Fly   395 NMVPPSMRATVAGVDL----------------------QPQEVKP-TYSNPELEMISKEIEELAR 436
            ..:|||.|...:|..:                      ||::..| |:.:.:.|...:...||.:
Mouse   326 EYIPPSFRRVRSGSGMSVISSSSVDQRLPEEPSSEDEQQPEKKLPVTFEDKKRENFERGSVELEK 390

  Fly   437 ER------------RVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDD 489
            .|            |:.:.|.|::|...|.:..:.|..|.||:      ||||.||...::|.::
Mouse   391 RRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE------KQLEKQRELERQREEE 449

  Fly   490 LQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTIN----EQEGE--LNAKRS----ELQ 544
            .:.::....|.        .|..|:..::..:.:.::..:|    ||||.  |.|:|.    ||:
Mouse   450 RRKEIERREAA--------KRELERQRQLEWERNRRQELLNQRNKEQEGTVVLKARRKTLEFELE 506

  Fly   545 KLKDEE--------------ASLQKEYDSNNR-------ELSKLTNHLQATQLQISSV----RSM 584
            .|.|::              |:.::|.:|.|:       |::.|...||.:|..:..:    :.:
Mouse   507 ALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQIL 571

  Fly   585 VTQLLETQRQM--TDALLICRAAME-------------------------------NQNAEL--- 613
            ..||.:.|:..  .|:||..:.|:|                               ||..||
Mouse   572 SDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVERETRSKLQEIDVFNNQLKELREI 636

  Fly   614 VSEYQLKIEPDFDEA--------RKTLTKEVQLPKDD--------------------------PF 644
            .|:.||:.:...:.|        ||:|  |::..|:|                          |.
Mouse   637 HSKQQLQKQRSLEAARLKQKEQERKSL--ELEKQKEDAQRRVQERDKQWLEHVQQEEQPRPRKPH 699

  Fly   645 EEN--------NSGAANQATNGFGSDPFSG--QPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSG 699
            ||:        ....|.:.......|..|.  .|..:||                       :..
Mouse   700 EEDRLKREDSVRKKEAEERAKPEMQDKQSRLFHPHQEPA-----------------------KLA 741

  Fly   700 AGSAFGQTQRDPFGSDA--------------FAANKSNAITPEPG-----KDDFGSDPFAALHAP 745
            ..:.:..|::.|....|              |.:...:.||.:||     |.::..:      :.
Mouse   742 TQAPWSTTEKGPLTISAQESVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDE------SQ 800

  Fly   746 TGQGQVLSPNAQ-KSG--PP------PRPESPSPALP---------PKKSKVPPPRPAPPRAAQP 792
            ||:...|....: |:|  |.      |..|.|:||.|         ||.:....|.|.|..:::|
Mouse   801 TGEPGWLGGELKGKTGWFPANYAEKIPENEVPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEP 865

  Fly   793 TGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSATALSP---------LPPTLPAPIPVVSGSSLL 848
                 |.....:|||           |:..||::...|         ..|:|..|
Mouse   866 -----STTPNNWADF-----------SSTWPSSSNEKPETDNWDTWAAQPSLTVP---------- 904

  Fly   849 DSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSG-SVAGAGA 912
                   ..||:.:::|.||                :.:|.::|||.|      |.| .|.|..|
Mouse   905 -------SAGQLRQRSAFTP----------------ATATGSSPSPVL------GQGEKVEGLQA 940

  Fly   913 DLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDA-----FGEIGTRKAPTP- 971
                                ::..|.:.::...:......|::|.:.     |||:..:|...|
Mouse   941 --------------------QALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPK 985

  Fly   972 ---SLITGP----TDFKDDPFKDYRYEDPFSIK---DPFAE---EGEE 1006
               .||:||    |.....|     .|.|.|:|   .|.|:   .|||
Mouse   986 SYVKLISGPVRKSTSIDTGP-----TESPASLKRVASPAAKPAIPGEE 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	36/88 (41%)
		EH	307..402	CDD:197477	33/94 (35%)
		SMC_prok_B	<423..>632	CDD:274008	62/299 (21%)
Itsn1	XP_006522994.1	EH	39..132	CDD:197477	36/92 (39%)
		PLN02983	<155..226	CDD:215533	20/83 (24%)
		EH	238..333	CDD:197477	33/94 (35%)
		Smc	<387..>694	CDD:440809	65/322 (20%)
		SH3	766..825	CDD:473055	12/64 (19%)
		INTAP	825..939	CDD:435467	37/168 (22%)
		SH3_Intersectin1_2	939..990	CDD:212922	9/70 (13%)
		SH3_Intersectin1_3	1028..1079	CDD:212924	1/1 (100%)
		SH3_Intersectin1_4	1096..1160	CDD:212926
		SH3_Intersectin1_5	1180..1233	CDD:212928
		RhoGEF	1260..1443	CDD:238091
		PH_13	1462..1604	CDD:465218
		C2_Intersectin	1604..1738	CDD:176021